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Opioids O-DSMT Megathread

It's possible that you don't really have tramadol, but you can only figure that out by having it tested.

What kind of doses are you taking? Those side effects can occur if youre just taking too much. Too me, it sounds like you've built some opioid tolerance, so now you've increased your dose while getting diminishing returns from the opioid effect and too much of the unpleasant SNRI effects.

I´m taking 5-15mg odT and 2,5-7,5mg U4 per Dose, the bad effects from odT were a year ago and the U4 has mostly bad effects this year. The only opioid I´m using constantly is Kratom, but a year ago the tolerance to it was very low, now it´s pretty high and the odT works like in 2011 really nice, it was probably something about interactions with other stuff. I took 3x10mg today along 3x4g good Kratom and it works perfectly, none of the side effects I had with U4 or the odT a year ago.
 
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I've found kratom and tramadol to be very synergistic, but it's also very dangerous just FYI. Some of the few deaths that have been associated with kratom were people that also had ODT in their system. The combo can cause seizures
 
^ a pretty dangerous combo indeed, I just skimmed over a case report of a man having a seizure most likely due to the combo of kratom and modafinil
 
Okay, people always told me that they would feel Tramacets on Suboxone (only comes as Tramacet here...well there's Zytram XL long duration pills....be surprised, I never ever saw it other than on government websites. The "Ultram XR" name you have in the US, as for it, the makers tried to have it made available in Canada but they refused the application at Health Canada. Likely cos there's already Zytram XL and it offered nothing different.

So, I always was confused by that...yeah there's the Wellbutrin effect, but what they told me is that is they felt opiated even if on a smallish dose of suboxone (say 4mg) and they'd have a 3-4 37.5/325 Tramacets and they said it was magically one of the other things than Abstrals (fent sublingual pills) that worked for pain in case you need a painkiller for Suboxone. I always was very unconvinced by all of that babbling.

I got the chance of obtaining some O-DT again, I am now taking 4-6mg suboxone, sometimes more, but rarely, only if for some reason I get some wd symptoms or got some Atarax 50mg to mix with about 10mg with benzos so I can nod really deeply....it works. That I know, the Atarax is a huge help for that.

What's the neurochemistry of O-DT, I've read before it was only a mu agonist unlike it's parent compound. If it is so...I think it could be a low strength full agonist I could use to get rid of Suboxone...I'm sick of it and the weekly pickups of my maximum 6 days of privileges and the side effects that have me needing to inject Delatestryl IM because methadone and less so Suboxone, but still, reduce my testosterone enough to warrant treatment, but then the gyno caused by the testosterone, had to take anti breast cancer drugs (anti-oestrogen pills they can also be called), Anastrazole, it worked, but it gave me chest tightening and pain which are actual side effects and I couldn't endure it anymore, so I just take about 1/4 of what my Testosterone script says I should take per week.

Dosage = 5-10mg?

Will it be felt over Suboxone like Tramadol supposedly is?
Does it keep the seizure inducing effects of Tramadol?

I need good answers and fast before supplies are gone...

Thanks.
 
So, nobody? I kept reading how people would feel Tramadol on Suboxone but chalked it up to the SNRI effects only being felt.

Bupe already plays with kappa receptors, I think too much k-agonism wouldn't be pleasant, as for the Delta opioid receptor....I never felt it was very important in determining whether something is pleasant.

If I can stop suboxone for some long enough time and take smaller and smaller doses of O-DT, which would be easier to control, would I have to wait a week or it works right anyway somehow over bupe.
 
O-DSMT hits a laundry list of receptors. The SNRI effects are what you're​ predominantly feeling if you're also taking bupe, but it also hits many other receptors. Opioid antagonists do not reverse the analgesic effect, so it's well known that part of it's activity is not at all related to mu-opioid activity. It's really as simple as that.

And yes, there's still a risk if seizures with O-DSMT.
 
Alright, so should I go ahead? I thought it was gone forever but nope, and the prices aren't ridiculous like years ago. Will I be able to feel it and prevent wd's if I say don't take my 4mg of suboxone a day for 48 hours?

What kind of dosage would that be? I read long ago that 0-tramadol was all opiate and no effexor effects (the difference between the molecule of venlafaxine and tramadol are impossible to distinguish to the untrained eye.) And as someone who is bipolar....slow cycling, but some bad experiences can cause a mixed episode to show up for me, sometimes, it's rare, even a not psychedelic trip will not cause this except for 4-aco-DMT did that twice, only my first experience with it was pleasant, after that it's like telling you to fuck off and get your brains out of its space, figuratively. Once before we identified the Bipolar thing, my psychiatrist tried me on Effexor XR 37.5mg to start with, and a single capsule got my pupils huge like if I had taken more than 1 average street acid hit, I had nausea where I had to take Gravol (dramamine) every 4 hours and the effects of alcohol did absolutely nothing and I was incredibly talkative although with a nasty feeling I associate with all SSRI's/SNRI's, well no Paxil didn't get me that feeling, but it made me go into a 2 week mania in the worst circumstances possible, lost my job, broke up with my girlfriend, left unannounced as she had driven 6 hours with her U-Haul truck just 20 days before to come live with me and I can tell you that Paxil reduced my inhibitions so much that I didn't feel a thing, violence, pain, happiness, all of those things didn't exist and I was an automaton going to work then who tried to sleep with the mere 0.25mg xanax x 4 a day I was given to counter the initial SSRI bad side effects, but once I was out of them, big big trouble.

And the time I was prescribed Tramadol by suggesting to it the ER doctor instead of what she was going to script me, Empracets (30mg codeine/300mg apap), I said, I'd like to give this less addictive thing that just came out and said Tramadol, she looked at me and she said you mean, Tramacet, it's got tylenol in it, there's no tramadol by itself here) and I said sure, whatever. Well just taking 4 37.5/325 Tramacets got me to walk back in a snow storm to the ER, yelling at the nurse that they scripted me poison and they changed it back to Empracets, I was getting that inexplicable Serotonin feeling that isn't pleasant at all, that I felt from Effexor, nortryptiline, Celexa and I think that's it, MDMA and MDA (maybe I had MDME but I wouldn't know) or serotonergic psychedelics don't give me that icky sensation except sometimes on the comedowns, but rarely.

So, I'm wondering, I just want to get rid of Suboxone so bad, this could be the answer, U-47700 when I had it, when I realized it was a Dilaudid like rush when injected, I injected the 100mg I had in 15mg shots and when it was over I didn't want anymore, it did go over the bupe though, which is very strange. I could buy it and just store it and wait until I'm at 2mg, which is an epic struggle, under 4mg it's like i'm in a mini-wd that 2mg does nothing for.

Oh and I'm aware Tramadoi hits a phone book thick list of receptors, ligands and sodium/calcium/potassium channels and things I forgot I know about, it's the dirtiest drug I've read about with Remeron....that stuff hits so much receptors at once it's quite spectacular.
 
^ has O-Tram become available again? always wanted to try it but i was just a it too late to the party last time ༼ ༎ຶ ෴ ༎ຶ༽


ha, O-Tram. OOOO tramada oooo tramadaaa
 
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Hey there guys, I'm planning on venturing into the world of research chem opioids- namely O-DSMT or O-Desmethyltramadol but I've got a problem that's probably shared by many others too. Please correct me if I simply haven't looked enough, but the problem is that I feel as though there's a huge lack of information on dosages (PW has a page for it, but I always look for multiple sources), experiences, and general information for O-DSMT. I've only seen small threads consisting of a few posts here and there, but no megathread for it, and considering how it's said to show more of the traditional opiate high (it was even compared to Morphine in one post) vs. Tramadol's stack of stimulation and opiate euphoria, it seems as though it would be educational to have a place for all to discuss this chemical. To start, if anyone has detailed experience reports- yes, I know about Erowid, but there's only 7 so far- please share then here, I'm very interested in giving this a try, as Tramadol is one of my favorite DOC's. And for all other information that anybody has, it'd be great to hear about that too, too much research can never harmful, but too little sure as hell can!
Thanks everyone!


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O-desmethyltramadol is the main active metabolite (metabolized by CYP2D6) of the pharmaceutical tramadol.
What we know:
The half life of O-DSMT seems to be around 9 hours [1]
O-DSMT seems to not be a SSRI (tested concentrations up to 5 µmol/l) [2]
(-)-O-DSMT seems to be a NRI [3] while (+)-O-DSMT might cause norepinephrine release [3][4]
O-DSMT seems to inhibit the serotonin receptor 5-HT2C [5]
(+)-O-DSMT has a Ki (in µM) of 0.017 for mu-opioid receptor (for reference morphine has a Ki of 0.0021), 0.69 for delta and 1.8 for kappa [6]
 
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Well ODMT is going to be similar if not identical to tramadol, save the potency. ODMT is pretty much the only reason tramadol gives any kind of high so any experience with tramadol can pretty much sum up a ODMT experience, except that ODMT experiences will be more consistent due to it not having to be metabolized before becoming active.
 
Well ODMT is going to be similar if not identical to tramadol, save the potency. ODMT is pretty much the only reason tramadol gives any kind of high so any experience with tramadol can pretty much sum up a ODMT experience, except that ODMT experiences will be more consistent due to it not having to be metabolized before becoming active.
Thanks for the reply. I read something similar to what you said, it was about O-DSMT just being the metabolite responsible for the analgesic properties of Tramadol, not necessarily the euphoria side of it. From what I've gathered by reading a couple experience reports as well as other research, there should also be plenty of room for "surprise effects" that the parent compound has that Tramadol is lacking of. I also notice that you're calling it ODMT, is that simply to shorten it or is it a more-known nickname where I'd be able to find more about it by searching?
 
That's just how I chose to abbreviate it, actually it's probably not a good idea since it kind of looks similar to DMT
"Tramadol- My Psychedelic of Choice" It would be nice for sure, but yeah, to clarify in case anyone else reads this, it's definitely not a psych or tryptamine...
 
You're right, it doesn't look like we have a megathread for O-DSMT, so let's start one :D

OP, I added a few things to your post, hope you don't mind
 
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To quote some more useful information that I found from a source online:
  • It has a longer duration than tramadol and more typical opioid-like effects, although it still impacts monoaminergic systems to an extent that seems to influence the effect profile.
  • O-DSMT has not been studied for medical uses, but it likely has efficacy in the same conditions as typical opioids like oxycodone and morphine.
  • The onset is generally around 00:30 to 1:00
There's some information on this that's easily found online, but I'm going to aim to only publish the hard-to-find pieces of information from now on.
 
Hey does anyone know what the dose conversion to hydrocodone or oxycodone would be?
 
Hey does anyone know what the dose conversion to hydrocodone or oxycodone would be?
Everyone's different, but in my limited experience with o-dsmt (tried it a total of 4 times and gave it away, you'll see why in a second) I found it to be pretty much equipotent to oxycodone. I found the effects to be extremely similar to oxy too, with a rather stimulating high. At the time I was taking 1-1.5g of codeine a day and whatever else came my way, so my tolerance to opioids was pretty solid. I started at 50mg and never went above 60mg. I found that dosage range to be very close to the equivalent dose of oxycodone (original 'contins), although others may disagree.
I gave away almost 5g because I was getting to the point where addiction was becoming detrimental to real life. I'd been playing the game for a decade give or take, and I got the o-dsmt as a tool to taper myself to freedom. However, I enjoyed it more that I thought I would, it was also better and more potent than I thought it would be. The last thing I wanted was to fall deeper, so fucked it off and quit 'em all.
Think I even had a recovery post somewhere...
My point is that cheap, potent and unregulated/unlimited opioids are a dangerous thing. If you're not already pretty deep I'd highly recommend newcomers stay away from o-dsmt.


Or maybe I was highly sensitive lol, who knows.
 
Hey sup guys it's odsmt something similar to tapentadol? Cause i love tapentadol and tramadol
 
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