Wikipedia used to say that tramadol's M1 metabolite (the very same drug this thread is about) was "50 times more potent than morphine." It said this around 2009 when many sources were selling O-Desmethyltramadol powder as an ultra-potent opioid (this led to initial disappointment, at least in my circle) and it would appear one such source used deceptive wiki edits for marketing's sake.
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OD Moderators: Keif’ Richards | negrogesic
Opioids O-DSMT Megathread
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metabolite is the keyword in there, you're not going to have a large amount of M1 in you. Codeine's main metabolite is Morphine, but you still gotta take 10x as much to have an equi-analgesic effect. Also, just because Opioid A is more potent than Opioid B, does not mean that Opioid A will fuck you up more. It just means that it has a higher affinity for the mu-opioid receptors. For example...Fentanyl is the second strongest opioid used in humans. I've had fentanyl IV before and I didn't feel fucked up at all. It's pretty much all painkiller. These are the type of drugs that they're trying to develop: painkillers stronger than morphine with no addictive side effects; this is because most legitimate patients want the best drug with the least amount of side effects so that they aren't impaired while they're trying to get through life. Yes, they will still make the patients that take them on a regular basis dependent on them, but they won't really get addicted to them because there is no high.
But like I said earlier, METABOLITE is the keyword there. The substance had to be broken down so that it could turn into that.
edit: I was wrong on that last bit I believe.
But like I said earlier, METABOLITE is the keyword there. The substance had to be broken down so that it could turn into that.
edit: I was wrong on that last bit I believe.
Yeah, but the drug this thread is about hasn't been metabolized yet 
It's not really M1 relative to itself, only to tramadol, so it's the primary drug in this case. I believe what you said in your previous post that it's actually 2-4x more potent than regular tramadol and was only citing a mistake (or misinformation) on Wikipedia that previously said regular tramadol's M1 metabolite (O-desmethyltramadol) was "50 times more potent than morphine." Sales tactic, IMO. I don't believe we're in any sort of disagreement here.
It's not really M1 relative to itself, only to tramadol, so it's the primary drug in this case. I believe what you said in your previous post that it's actually 2-4x more potent than regular tramadol and was only citing a mistake (or misinformation) on Wikipedia that previously said regular tramadol's M1 metabolite (O-desmethyltramadol) was "50 times more potent than morphine." Sales tactic, IMO. I don't believe we're in any sort of disagreement here.
mydrugbuddy
Bluelighter
Im not having much luck with vaping this stuff. Well i should elaborate on that a bit; it seems more effective at much lower doses when smoked compared to taken orally but it has a foul fishy taste when smoked (or is that just me lol) and it dries out the airways extremely badly. In short, it seems very unhealthy. It seems i should really try plugging the stuff; its expensive and doesnt offer all that much "bang for the buck" when taken orally. so any way of effectively doubling the potency of the stuff should be wortwhile. (I'm new to the stuff but with oral dosing i already seem to need about 300 mg over the course of an evening, and a few beers for a decent 'hit' on the stuff. Maybe this substance isnt really for me, but i'll keep experimenting a bit longer)
knock
Bluelighter
Took about 60mg methiopropamine and after an hour or so 150mg o-dt, nodding quite strongly! CEVs and OEVs too. was watching the cat and she turned into a little man with an umbrella! Struggling to type properly too. Not had this before (the visuals)! Quite cool though! Didn't realise visuals like this were a possibility. Only downside is I'm sweating like a cunt :D
And there goes my dinner....
And there goes my dinner....
mydrugbuddy
Bluelighter
Has anyone combined o-dt with mdai, stims and booze ? Im considering trying about 130 mg of o-dt, with 150 mg of mdai, a few lines of 4 mec, a few beers or a couple of glasses of red wine this evening....Does this sounds like the ingredients for a good session or a recipe for disaster ?
It sounds like it could be quite blisfull to me, in theory... Any one have any simillar experiences or thoughts ?
It sounds like it could be quite blisfull to me, in theory... Any one have any simillar experiences or thoughts ?
Grondelduck
Bluelighter
Coincidentally.. just yesterday I had a night which involved quite some amphetamine, gbl, a bit of etizolam, and I wanted to end the evening with some zopiclone. Otherwise they would knock me out hardcore, but not after that evening. My mood was going down, and I tried to end the evening with o-dt (sometimes helps me sleep). The opposite happened. I took the o-dt in the morning, about 40mg nasally. Got a good mood lift off it, redosed only 2 or 3 times today on the amphetamine and I'm still doing great and I'm focussed, music sounds awesome and gotten a lot of work done today
Mind you, I'm actually quite suprised myself as well about how great I'm feeling even though I had little to drink, no meal since yesterdayevening (Had a banana this morning just to get something in there). Knock on wood 
For instance, being fully coherent and clearminded was the last thing I expected to be at this point. Contemplated sleeping this afternoon, but I was getting work done and I feel superb so I might as well sit this evening out and sleep in my normal rhythm.
Kronos
Bluelighter
- Joined
- Aug 10, 2010
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- 2,360
Got a v high tolerance though. Dont think i did miss em actually, just my hands are shakey as fuck so i switched arms halfway through injection. No bruising or swelling or owt, i just didnt get a rush, which was weird cause once i got an amazing rush from IVing odmt but these days i get better effects from bombing it. Just came outta my noddyness now 
and had another look and my arms look fine. Nice little 6 hour break from shit though, odt + promethazine + hash + vals = mmmmmmm
and had another look and my arms look fine. Nice little 6 hour break from shit though, odt + promethazine + hash + vals = mmmmmmm
Beerman
Bluelighter
Hey guys, I have one question for you who seem experienced on O-DT withdrawal. I took my last dose (about 50mg) Iv'd half an hour before, before this I have been reducing from 100-150IVd 3 times a day to 30-40mg for 3 days. Today I said "fuck it, I'll try to sleep with some diazepam or etizolam, clonidine, weed, alcohol, whatever I have to help, and in the morning I think I would be ready to take some Suboxone."
I am right? Is it going to be enough time (I know every one is different, also happened to me taking last dose of H before bed months ago and I woke up fucked up with mild WD and I took the subs and go straightaway to precipitated wd, other times I did what I did now, take the dose at noon, then try to have some sleep at night and in the morning I was ready for the subs) but as the half life of O-DT is longer (isn't it? 9h or so i think) than H I don't know if it's going to be allright take the subs at 6 in the morning tomorrow 18h after last dose.
Anyone knows if I have possibilities to go into PWD if I do like this??
Also I have only 2mg of bupe I don't know what the fuck I'm going to do, I have to go to work on wednsday, anyway I'm going to try to get more O-DT until I got more subs, then taper and defenetly stop being hooked in opiates........
Any info will be really apreciated.
Cheers.
I am right? Is it going to be enough time (I know every one is different, also happened to me taking last dose of H before bed months ago and I woke up fucked up with mild WD and I took the subs and go straightaway to precipitated wd, other times I did what I did now, take the dose at noon, then try to have some sleep at night and in the morning I was ready for the subs) but as the half life of O-DT is longer (isn't it? 9h or so i think) than H I don't know if it's going to be allright take the subs at 6 in the morning tomorrow 18h after last dose.
Anyone knows if I have possibilities to go into PWD if I do like this??
Also I have only 2mg of bupe I don't know what the fuck I'm going to do, I have to go to work on wednsday, anyway I'm going to try to get more O-DT until I got more subs, then taper and defenetly stop being hooked in opiates........
Any info will be really apreciated.
Cheers.
Beerman
Bluelighter
I know, but it depends in a lot of things, drug you are withdrawing, ammount, ROA, and methabolism. Sometimes I did bupe 18h after H (low dose) and nothing happened.
Anyone else any help please?
Anyone else any help please?
Beerman
Bluelighter
Uh, I guess I was too scared about what could happen... actually nothing really bad (chills, cold sweats and mild insomnia) I don't know why I was expecting so bad wd etc, etc.. but with 20mg of valium, 0.125mg (I think so) of clonidine and some good quality weed, more or less did the trick, (last dose ~50mg of O-DT at noon) not so dificult to fall asleep at 11pm, wake up after 2h of sleep, smoke weed +5mg valium, toilet, 2h of sleep, weed and then 3h awake until I dosed 0.1mg IVd, bupe, now completely fine, happy, with hunger, energy... lol
Before this, I have been tappering on subs till 0.02mg a day -almost nothing, weeks ago then I was 10 days doing H not heavy, (one "bag" a day, i guess arround 350-400mg, white low-medium quality I would say). Just after this habit (I had not acces to H anymore) I swaped for O-DT -never tried before- which in the first times seemed to do nothing at 50mg IVd, just smooth relief some of H wd but nothing special, but after the days trying different doses I was doing 100-150mg per shot 2 or 3 times a day. I guess my scaring was because I was expecting some kind of H like horror wds I had in the pas... that thouhgt of "I know in few hours I'll be in wd.." but with an "unknown" opiate for me, maybe put my mind in the worse case scenario or well also sometimes mixing a-ppp to the o-dt shots made me a bit paranoid or something like... 8(
Sorry for looking like a stupid in those previous posts lol
Now it's funny to see how completely fine I'm doing only 0.1mg of IVd bupe 20h after my last dose of O-DT..
Well hope this WTF "story" helps someone
Thanks a lot to everyone!
Cheers
fistful_of_needles
Bluelighter
subject :male, 38 years, 85-90kgs- 1.81m ,on relative low daily dose of Subutex (maintenance) for over 4 years now ,tapered to 0.5-2mgs(tops) daily
so haven´t been able to find any info on the following combos I decided to order some O-desmethyltramadol/mxe and Camfetamine...
having tried all of the aforementioned on their own, with O-dmt being the exception.
It´s now 13:55 and this is what I´ve tried so far:
10:00am 2x50mgs tramadol IRs + 1x100mgs SR tramadol + 10mgs Valium (Roche)
at roughly 1pm the postman arrives with my parcel and having no scales and being pretty tolerant to tramadol I limited myself to eyeball
what I´d assume was just over 200mgs of O-desmethyltramadol...divided it into 2 fat lines for insufflation...
well, being tolerant to Tramadol and having had no Buprenorphine in my system for over 24 hours (last dose was yesterday and around 0.5mg)I should have been
feeling rather sick as I normally do when I dose that low-ish on the previous day...well,1 hour after the 200mgs insufflated dose of O-dmt I felt no need to take my daily bupre dose
actually I felt pretty good on it alone...
2pm : now comes the part I was curious about,"will O-dmt compliment low doses of buprenorphine?" ...So I cut another 2 lines of less than 0.5 mgs of Bupre and add
a small amount of Camfetamine (10-20mgs) to the mix knowing that I should not overdo it cause of the seizure threshold when combined with tramadol,perhaps
(pretty ignorant on these things as one can easily perceive)...
2:45pm :still nothing out of the "ordinary",as in I feel pretty awesome as if I had used a full agonist...so time is ripe to add a small bump of MXE (20-40mgs range)
...
2:50pm :decided to call a mate and then suddenly it all got very pronounced ,the unusual interest in each and every theme which would normally bore me to tears or at least towards indifference,
this to me is "euphoria"...that state of well-being which seems to be impossible to get disrupted by anything...from here on I decided to do some work in my home,as in scraping paint off of walls so I can re-aint it etc etc...
5:00pm :no sigs of any kind of adverse "syndrome",just an awesome amalgamation of substances pushing me towards consistent/constant euphoria/joy, work felt great,blasting Burial´s "st" while at it was a major plus...
basically a BIG thumbs up to this rather ecletic combo which I by no means condone but take it for what it is...sure is working for me
.
so haven´t been able to find any info on the following combos I decided to order some O-desmethyltramadol/mxe and Camfetamine...
having tried all of the aforementioned on their own, with O-dmt being the exception.
It´s now 13:55 and this is what I´ve tried so far:
10:00am 2x50mgs tramadol IRs + 1x100mgs SR tramadol + 10mgs Valium (Roche)
at roughly 1pm the postman arrives with my parcel and having no scales and being pretty tolerant to tramadol I limited myself to eyeball
what I´d assume was just over 200mgs of O-desmethyltramadol...divided it into 2 fat lines for insufflation...
well, being tolerant to Tramadol and having had no Buprenorphine in my system for over 24 hours (last dose was yesterday and around 0.5mg)I should have been
feeling rather sick as I normally do when I dose that low-ish on the previous day...well,1 hour after the 200mgs insufflated dose of O-dmt I felt no need to take my daily bupre dose
actually I felt pretty good on it alone...
2pm : now comes the part I was curious about,"will O-dmt compliment low doses of buprenorphine?" ...So I cut another 2 lines of less than 0.5 mgs of Bupre and add
a small amount of Camfetamine (10-20mgs) to the mix knowing that I should not overdo it cause of the seizure threshold when combined with tramadol,perhaps
(pretty ignorant on these things as one can easily perceive)...
2:45pm :still nothing out of the "ordinary",as in I feel pretty awesome as if I had used a full agonist...so time is ripe to add a small bump of MXE (20-40mgs range)
...
2:50pm :decided to call a mate and then suddenly it all got very pronounced ,the unusual interest in each and every theme which would normally bore me to tears or at least towards indifference,
this to me is "euphoria"...that state of well-being which seems to be impossible to get disrupted by anything...from here on I decided to do some work in my home,as in scraping paint off of walls so I can re-aint it etc etc...
5:00pm :no sigs of any kind of adverse "syndrome",just an awesome amalgamation of substances pushing me towards consistent/constant euphoria/joy, work felt great,blasting Burial´s "st" while at it was a major plus...
basically a BIG thumbs up to this rather ecletic combo which I by no means condone but take it for what it is...sure is working for me
.
fistful_of_needles
Bluelighter
hmmm,not wishing to be a dick or anything but that is a bit on the fairytale side of things,really ...I´ve done bupre after good quality IV heroin with just a couple of hours inbetween them and had nothing I´d associate with "precipitated withdrawals" or anything,perhaps just some mild dysphoria but taht was about the size of it...by the way ...it´s some hours after the combo described above and,well... been putting some strain on my body by having just returned from the gym lol,simply couldn´t stay indoors...had to get physical about it...no serotonin anomalies or seizures or precipitated diharrea syndromes or anything...think I´ll just have a hot shower,nice meal ((un)fortunately no "suckee-fukkee") and dive nose deep into the MXE-Void with some bupre/O-desmethyl canisters (Opiates/oids are precious out there lol)
Be safe
JJ-180
Bluelighter
ODT seems to have in common with other opioids the fact that each w/d is nastier than the last. I've just done my 3rd ODT w/d and it wasn't nice at all. My first w/d was a breeze-really nothing to it, the second one only lasted about 2 days and was fairly mild but this time it was full-on for 4 days and I'm still feeling it.Mind you, the fact that God chose to reveal his (as ever)lousy ironic sense of humour by having me trip over on the second day and break two ribs didn't help at all.
fistful_of_needles
Bluelighter
based on what I felt yesterday a good 6 to 8 hours after I did a 200 mgs(roughly) dose (1st time trying it) ; had some increments later on in the evening , all in all I must have done no more than 400mgs ,but I´m pretty tolerant to opiates anyways and this drug actually did what only high doses of IV heroin managed to do in the past , as in projectile vomiting and that feeling of well-being which ensues which most of you H users should know about ...this and the way I kept on waking up throughout the night, half asleep/half awake ...the itching, you know ...ALL tell tale sigs of a strong opiate...in short,even with an opiate tolerance and being on bupre for years not only did I felt it combo´ed with the latter but also it felt like a proper opiate...so the withdrawal symptoms you refer to make perfect sense...I sense this won´t be available for long...
I recently ran short on O-DMT. To get the maximum out of my last ~40 mg, I chose i.v. as ROA. (Normaly I'm plugging O-DMT)
Unfortunately the high was not as good as I had hoped. Ok, the onset was fast, but I didn't feel any sort of "rush".
Since I suppose there's no data available about different ROAs and their bioavailability, what are your subjective observations? How much O-DMT i.v.d equals 10 mg plugged?
Unfortunately the high was not as good as I had hoped. Ok, the onset was fast, but I didn't feel any sort of "rush".
Since I suppose there's no data available about different ROAs and their bioavailability, what are your subjective observations? How much O-DMT i.v.d equals 10 mg plugged?