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Just some high speculation. I'm not making an entire thread for this because I don't want to waste forum space if I sober up and realise this is a ridiculous idea haha.

Well as some of you know, one of Paracetamol's metabolites is AM404. AM404 produces similar analgesia to extremely small amounts of THC, this is because it's a Cannabinoid reuptake inhibitor. Studies have only look at it's ability to stop the reuptake of the endocannabinoid Anandamide, but I'd suspect that it would have a similar effect on other Cannabinoids. Would this not mean that Paracetamol should in theory potentiate Cannabis? Not suggesting it as an idea, since we all know Paracetamol is highly hepatotoxic - but I just started reading and it got me interested, so I was wondering if any of the chemistry geeks here could offer their thoughts/opinions. Edit: Having said that, I'm starting to think my idea is ridiculous since surely reuptake inhibition is only for endogenous chemicals?

Annnnd, on a more social note. How's everyone today? :)
 
What you're talking about would be analogous to taking an SSRI along with a psychedelic, right? I don't think that would work. And yes, reuptake only happens to endogenous chemicals ;) What you want is a pharmacology nerd, not a chemistry geek (cor, get it right!); you could perhaps post in the ADD "Not quite advanced" thread if you wanted, though I don't think you need to...
Annnnd, on a more social note. How's everyone today?
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Super, thanks. Yourself?
 
Vader said:
You live and you learn, eh?
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it's not the worst situation to have.

chainer said:
Bubble Kush - Turned a Z into hash - mmmmm.
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BubblekushHash.jpg
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Makes sense, my knowledge of pharmacology is rather lacking, but I like to learn, so that's why I read up about these kinds of things and pose these questions. Always had an interest in chemistry, medicine, pharmacology, chemical synthesis etc. Having read a little deeper on the subject, it seems that to potentiate exogenous Cannabinoids you need to inhibit certain metabolic enzymes, interestingly your reference to SSRIs, which off-topic, was rather appropriate as from what I've read certain SSRIs inhibit these enzymes and so can potentiate Cannabis. However, I personally have an inherent fear of SSRIs causing permanent downregulation of my Serotonin receptors so it's not something I'd risk experimenting with.

I'm really good. Believe it or not I've smoked a total of 5 or 6 times in the past year, finally got my hands on some real quality herb (1-hit quitter stuff) at the weekend so I'm rewarding myself for my coincidental tolerance break :) The irony of it all is that I had access to herb here, but didn't buy any due to fears that it would be extremely low quality, when as it turns out this is probably the strongest bud I've ever smoked (and I'm used to only smoking very high quality as is!) - last night I rolled myself a nice spliff with a mere ~0.2, and just half way down I had to put it out and wait a good half an hour before I could finish it. Astonishing to me.
 
SSRI down-regulation will not occur prior to 2-3 weeks of use and will cease 28 to 72 days after cessation in normal case study agents.

I personally believe SSRIs/SNRIs to be the devil's plaything, but they have worked wonders for a lot of my friends.

And I wish I had your tolerance.
 
There's an RC (URB-something I think) that acts as an enzyme inhibitor, and so increases endocanabinoid levels, but I wouldn't touch the shit with a long shitty pole. Enzyme inhibition is dangerous, you need to know what you're doing, and to do it with a totally unresearched drug? Forget it.

Ha, glad the polska weed is treating you well! I can't say I'm surprised that it's strong, the Poles know how to have a good time.
 
Haha they sure do. We made 1g, no joke, last 4 people an entire day of hitting those little 1-hitter pipes (which they sell for as little as 5 cents here!) and being incredibly stoned. If it wasn't for that I'd have thought it was just my low tolerance after not smoking for so long, but the 3 others are all very regular smokers, with one smoking mostly all day every day - and they were all very very high. I had one of those scared moments where I thought it was laced when I first smoked it, because my mouth went numb.. then I realised the cigarette someone handed me after I finished was a menthol. Rofl.

Thanks for that Chainer, is that true even in people who have used for years? I'm particularly worried about my own mother who's been taking them daily for > 15 years. I have to admit though, I somewhat quickly jumped to conclusions simply by noticing that people who had taken SSRIs years ago needed larger doses of psychedelics, and not through any academic research, peer-reviewed studies or anything - so my conclusion was probably inadequate and mostly wrong.

Interesting regarding the RC. I wonder if in the future drug users as a group will have a good knowledge of the enzymes and what they break down? Similar to how nowadays most people have at least a laymans knowledge of the different classes, and serotonin, dopamine and epinephrine/norepinephrine.

Just hit the end of last night's joint and I'm feeling nice and mellow. Anyone have any relaxing smoking tunes besides the obvious stuff? :)
 
There aren't many long-term studies done on uptake after years of seratonin regulation drugs. The way SRRIs work, though, suggests that cessation will eventually lead to normalization. They should effect psychedelic dose while the drug is still active, but I will say that I have been on a number of them in my teenage years, and my psychedelic tolerance is head and shoulders above everyone I know.
 
Ah I see. Well I sure hope the uptake does return to normal as SSRIs seem to be extremely over-prescribed these days and I'd hate to see them leading to much more depression than they treat.

I'm curious if anyone here has smoked weed while drinking absinthe, and what they thought of it? I'm a fan of drinking when I toke, but I've heard that wormwood in absinthe offers a very clear-headed lucid experience and so I think it might be great for the combination. I've never tried absinthe before so I have no idea how it subjectively differs from other liquor, but I imagine it should be interesting either way. :)
 
im with you on that one. lovin' the hash i made, it's almost gone though!

I think i'll give the zip I used a second wash, maybe get another half g out of it or something.
 
I really miss hash, haven't smoked any in a long time. But man this bud is delicious, as is this absinthe. I'm in a very good mood tonight, and I hope everyone else here is enjoying their evening/morning/night too :)
 
Think it's time for me to take a break again, it's getting ridiculous now smoking through ~2g a day & it's just not managable on my finances atm. It's been a while though and i've got this quart to polish off before I do anything..


Gonna be a pretty average week i'm thinking :(
 
Vader said:
Or ground weed, that's how they used to make "Texas hash" back in the day.
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how would you smoke this? wouldn't it just light on fucking fire? lol. I have been spreading it on wrap and melting it onto bongs.

kaywholed said:
mix it with bubblehash or kief.
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How well does this really work, and how much kief would you need for it to be a bit more manageable? As is, I can't even touch it to anything but metal if it's not frozen. I imagine I have about .5g of kief laying around.

edit: yicks sorry for the double post
 
edit: yicks sorry for the double post
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It's OK mate, it's not like you can merge posts or anything ;)
idk about smoking the "Texas Hash", obviously I wasn't in Texas in the 80s, I've just read about it, but I imagine you just break it up and smoke it in a bong (or a nice spliff, but I'm probably not going to convince you there...). What makes you think it'd be especially prone to combustion?

IIRC, oil mixed with unpressed bubblehash is known as "jelly hash", and apparently it works quite well.
 
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