Alcohol now someone told me that drugs and drinks dont mix, but...

[Deadeyes]

so the other day i was at this security class, and someone said booze and drugs just dont like each other. naturally everyone looked at that person and said no duh. but that someone else said,that if its a controlled substance, say like Tylenol, than what it does is increases its effects. the class was told to stop talking at this point cause it was off topic.

so my next question is...
Is this true. i mean if i take 1 pill of Tylenol 2 with codeine, and have a small glass of rum, or beer, or vodka, or even whiskey. what will the end result be?

will it foam up somewhere in your system as soon as the drink comes in contact, will it increase or even decrease the abilities in which it works? will it slow it down, or speed up the time in which things take effect? and can that simple and small combo be so bad that you just gave yourself a overdose on 1 mare pill, and a glass of drink?

also and this is to go along with my earlier question. would crushing up pills, and than dissolving them into a drink do anything? whether or not that drink is booze, or water. what would the results be with either of the options standing.

for example, if i take measuring cup of water, and dissolved 1 Tylenol 2 tablet in said water, would the pill still work like its suppose to if i drink all that water down? will all its effects still be the same? will it still take the same amount of time to take effect.

and than change Tylenol 2 for Benadryl for both examples. what do we come up with?

and what if you did this same example in 1 cup of your favorite drink like vodka or rum? would the pill still work like its suppose to if i drink all that substance down? will all its effects still be the same? will it still take the same amount of time to take effect.

and finally what would happen if you mixed both pills in the same drink? would the results remain the same both just have both meds in the drink? whether it be water or booze.

 

[Tommyboy]

For something with Tylenol you don't want to mix it with alcohol because it damages the liver more.

Alcohol usually increases the effects of some drugs, particularly CNS depressants such as opioids and benzodiazepines. The problem with combining them is that it can cause respiratory depression which can lead to death. Mixing it with benadryl would just cause more drowsiness.

Some people prefer to use certain drugs on their own though. Those that enjoy an opiate high often find that adding alcohol to the mix just makes the high 'dirty' rather than making it better. But some people that may be more into the buzz from alcohol may enjoy the added effects of some codeine, but there's a good chance that after a while they may form a liking to just codeine and just do that on it's own and eventually become the type of person I described before that doesn't like to mix the two.

It's very important to know how a drug effects you on it's own before you go mixing it with alcohol. It's also important to take lower doses of both substances when mixing the two.

 

[Deadeyes]

i thank you for your timely reply.

codeine is a opioid correct?

if so than mixing the too could cause my lungs to fail or future breathing problems?
and lastly. could this cause some sort of an overdose even in low doses?

 

[EP158207]

No, codeine and alcohol will not cause your lungs to fail or future breathing problems. It actually just makes you breathing much shallower, to the point where you dont even notice it when you drift off to sleep and then die. It doesn't actually affect the function of the lungs.

 

[sekio]

Combining codeine and alcohol can also cause you to vomit and if you're in a reclining position you can inhale that vomit and damage your lungs or die. So just be careful.

 

[Lorne???]

No one mentioned that's a recipe for nausea!

You're friends dumb, there is no magical enhancement, any 2 CNS depressants(hell, any two drugs) enhance each other, but alcohol doesn't potentiation opioids through any mechanism.

People also speedball, it's not necessarily advisable though.

 

[Deadeyes]

No one mentioned that's a recipe for nausea!

You're friends dumb, there is no magical enhancement, any 2 CNS depressants(hell, any two drugs) enhance each other, but alcohol doesn't potentiation opioids through any mechanism.

People also speedball, it's not necessarily advisable though.

So basically, if you have a t2 with a glass of booze, your throw it up? If there a way to stop that from occurring?

 

[sekio]

It's not a guarantee, it's just something that could happen.

 

[neurotic]

not a good idea to mix the acetaminophen in the T2 with alcohol as both are bad for your liver, just like it was said

but yeah mixing codeine with alcohol will increase CNS depression, so not a good thing to be done recklessly, but still doable you know just don't exhagerate. i don't know how much codeine is in a T2 but i doubt taking one pill and drinking one glass of beer would make you throw up.

 

[Deadeyes]

T2 is 300 mg ace, 8mg of caffeine, and 15 mg of codeine, my research into codeine suggest that LD50 for an adult is around .5-1.0g.

If you dissolve this drug into booze, would that lower the changes of vomiting? Or increase it? Like what is it in the codeine that causes us to vomit?

 

[neurotic]

all opiates tend to cause nausea, it's a common side effect, but tbh 15mg codeine is not even enough to get you high let alone cause nausea

why do you want so bad to mix the two?

 

[Deadeyes]

It's a project I started to work on with a few security co-workers. Non of us have medical degrees, nurses in town said they have never heard of someone trying it, let alone attempting a OD on this scale. And the 1 doctor I spoke to said and all her 23 yrs in practice she hasn't heard of limits being reached. So I figured I'd ask here cause everyone here seems to have a fair amount of info on drugs, and there is more experience to go around. As for me attempting this. I hate throwing up, I have a gag reflex that would make you all laugh your arses off to death.

So if 15 mg wouldn't set off the vomiting or gag reflex, at what amount will? And again, would dissolving the pill minimize that effect? Do we vomit cause of a chemical reaction to the opiates? Or are they made like that to prevent ODing?

 

[Kittycat5]

I dont think anyone can say exactly what dose with trigger n/v. Crushing it will have no effect on this. And the tablets arent made to induce vomitting, it is just a biologic response to the drug.

 

[Lightning-Nl]

...alcohol doesn't potentiation opioids through any mechanism..

Not only is this incorrect, it's dangerously incorrect. Alcohol more than definitely potentiates the effects of opioids through many mechanism. To name the top few, GABA allosteric modulation, NMDA antagonism, Glycine agonist, Adenosine Reuptake Inhibition, and a plethora of many other speculator actions.

Combining Alcohol with opioids, is just as dangerous as combining opioids + benzo's. Actually no! It isn't! Alcohol is actually more dangerous than benzo's due to it's effects as an Adenosine uptake inhibitor, glycine agonism, and NMDA antagonism. In short, NEVER combine Opioids with Alcohol or Benzodiazepines. Doing so is a recipe for death.

Always remember, there is nothing recreational about death. So don't even chance it.

 

[Lorne???]

Don't be overly fucking dramatic. I like you, as a poster, you're intelligent, but you sound like an ass. Naming off multiple receptor targets that are not "potentiating" opioids. Alcohol isn't effecting opioid metabolism, not dramatically increasing AUC, half-life, etc. his friend claimed it increased the effects of opioids, it clearly does, but through synergy, not potentiation.

You completely misunderstood me. Read my last sentence. "People also speedball, it is not necessarily a good idea".

I was saying that mixing opioids and alcohol is inadvisable.

How and why alcohol induces it's depressant effects is irrelevant. All that matters is that combining alcohol and opioids is dangerous, mostly because of respiratory depression, and aspirating your own vomit, as mentioned earlier.

But do you know what is actually very dangerous? Exaggerating the very real risks of mixing CNS depressants. You're right, we shouldn't mix alcohol and opioids. But guess what? We shouldn't shoot up drugs, either. Hell, we shouldn't even be doing drugs, by that logic. But we do. And we shall continue.

People drink and take opioids all the time, so quite clearly it is not an automatic death sentence, and going crazy about alcohol's multiple(but very minor) mechanism's of action,that are irrelevant to opioids directly, and that a layman doesn't understand anyway, and providing no alternative save abstinence, is dangerous, because when people see there friends drinking whiskey and popping pills and remaining very much alive, well, you're advice goes out the window.

"A recipe for death". Seriously, man, listen to yourself.

People, you shouldn't mix opioids and alcohol, not because of "speculator action" but because it is dangerous, and alcohol also lowers inhibitions making it harder to be responsible. But clearly, if you are tolerant it is possible to mix them in moderation, but even that is unadvisable, as most agree that alcohol just overpowers the opioid and causes emesis anyway.

Sekio said it best:
"Just be careful".

(Lorne's note: Alcohol actually can modify opioid metabolism,(affecting BA, Tmax) and very large doses could (possibly) effect phase II metabolism, but not to an extent to use it as a potentiatior.

 

[tmuliosis]

This sounds like a young kid who just recently realized drinking leads to intoxication and has otherwise been experimenting with alcohol. Don't drink too often or you'll become one of those alcoholic kids that doesn't graduate! And stay away from opioids -- because if you had done any decent opioids, you'd already be addicted to them and not be curious about ruining that opioid high with nausea by adding alcohol to the mix.


Just say no! Don't mix pills with alcohol -- it's not usually a fun experience unless you're an alcoholic with an extreme tolerance, and even then, it's very dangerous.

 

[TheLostBoys]

A friend of mineuse to pop the 40mg original OC's & use to drink 2 or 3 beers & he absolutely loved the combo but he also had a huge tolerance to alcohol & a moderate tolerance to opiates.

I use to tell him he shouldn't mix it but he never listened........luckily nothing ever happened.

As others have mentioned, never mix alcohol with apap/opiates or just plain Tylenol. I know a girl that will drink a few beers & pop 2 Tylenol's for her headache, not a good idea. She will even pop 10 Tylenol in 1 day for her pain as she is a waitress.. ...stay far away from mixing alcohol with Tylenol & other strong pain meds.

 

[Lightning-Nl]

[...]

I'm not sure if I wrote my original post correctly. I'm incredibly high at the moment - so much so that I'm not even sure how I'm typing this out - especially since I can't see straight. But lemme see if I can explain better what I meant.

I meant that everything is connected. Everything in the universe, everything in the world. The keyboard I'm typing this on, is also part of the universe. We all have one thing in common, we all 'belong' to this universe. Whether we ever find it possible to 'leave' this universe is something that may or may not happen. In fact, other universes may not even exist for all we know. But I do know one thing that everyone, all living things in this universe with the capacity to think such a thought.... the definition of home. Where is home?

That is something I know that everyone can answer (I count homeless people calling home, the city they were born in/choose to be in) I know one thing - there is always a place that people consider 'their home'. If someone were to ask you where you live, you would respond with something like "At Northwoords 12345 Avenue East, St. Louis, Missouri, 63006" - If you went to a different country - they would have no idea what your exact street you live on is called - so you just say "Oh, I'm from Missouri in the United States.

Now lets say you go visit an 'alien' world and you meet some nice ol' aliens there and they ask you where you're from - what would you tell them? A street number? A city? A state? A country? - No of course not, because they would have no idea what you're talking about, but it's quite possible they would know what planet you mean - so you would just simply say "I'm from planet Earth"

Anyways, I hope you get my point - that there is an explanation, but sometimes the exact explanation would is not something that could be understood, by anyone or anything - except you. So you say the first thing that you know, whatever is asking you 'Where are you from?" - even outside our own universe - you would still say, I'm from 'this' Universe. No matter what, you can never change the fact that you were born in this universe, and that's something that everything and nothing shares.

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Now lets put it this way, but shrink that same idea, that same concept, that same truth (because it is the truth - we are all from this universe and nothing can change that) and apply it to the human body. We are, our bodies. We didn't choose it - we didn't pick it, it just was and always will be 'your body'. But more of what I mean is - you are your body, and you are the creation of two things coming together to make one.

In that same sense and meaning, every 'system' in the body is connected to every other part through means of downstream messaging from nerve impulses generated anywhere in the brain, and some that are also controlled by your spinal cord. Basically, think of the neurotransmitter and, well... Actually think of the entire nervous system as a chain of dominoes that never ends, until you "end". One thing always leads to another.

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I woke up about a half-hour ago, brought my computer out of sleep, and noticed that I had this post (above) just sitting here. I have no idea what it's about, but here's a page worth of philosophical thoughts that no one will understand... enjoy

 

[RTrain]

Yea, its all about moderation when mixing alcohol with any drugs, but most certainly other CNS depr. like Benzos or opiates. Now I have done it many a time, I know my limits and have never gotten into any serious trouble from it. Went a little overboard and end up blacked out a few times, but I actually find just alcohol on its own has caused this issue far more times for me....and those times I tend to be more rambunctious on the alcohol alone. Probably because when I add in other things I know to pull way back on the alcohol intake, but when I would just drink (rare nowadays) I found no problem going crazy, blacking out and regretting it someway or another. There was the 1 time I still had a relatively low opiate tolerance, so I did enough to get high but not nodding out. I also drank a ton (ended up blacked out) and tried to walk home about 3 miles from a party. Well I made it 1/3 the way and passed out along some grass and bushes, so a cop scooped me up and dropped me off at home, nice of him

 

[Deadeyes]

This sounds like a young kid who just recently realized drinking leads to intoxication and has otherwise been experimenting with alcohol. Don't drink too often or you'll become one of those alcoholic kids that doesn't graduate! And stay away from opioids -- because if you had done any decent opioids, you'd already be addicted to them and not be curious about ruining that opioid high with nausea by adding alcohol to the mix.

nope im 28 and cant drink no more. stomach is pretty screwed up

this is coming a pretty interesting study as it were. but some questions went unanswered. now before you say it, yes i get the point, dont do it cause you shouldnt do it. but, i like an answer just so i can say "hey guys this is what folks i met came up with".

So if 15 mg wouldn't set off the vomiting or gag reflex, at what amount will? And again, would dissolving the pill minimize that vomiting effect? at what limit, will A: you start vomiting, and a OD could be or rather should be intermediate? and B:in the event you do end up starting to vomit, what can be down to either stop it?, if you want to make sure the pain killers do get rid of the headache.

im assuming the effects of this kinda OD would be the same as ODing on the drug itself without the drinks. just cause from what i'm getting out of what was said is that yes, booze will increase the effects of the pill, and its timing