Ham-milton
Bluelighter
- Joined
- Jul 20, 2007
- Messages
- 5,738
Wait, was prolintane an unscheduled, approved drug??
Shouldn't be too hard to get, then. No?
Shouldn't be too hard to get, then. No?
-
N&PD Moderators: Skorpio
Novel stimulant compounds (perhaps with less spam than the 'stims of the future')
- Thread starter Riemann Zeta
- Start date
fastandbulbous
Bluelight Crew
^ It's a class C in the UK, so that sort of buggers getting ahold of it fairly easily. My experiences with it were when it wasn't a controlled drug as it was one of the compounds involved in my post grad work (I sort of dipped into most of the non-controlled compounds out of a sense of curiosity!)
hussness
Bluelighter
is it neurotoxic? It's rare now that I run into purportedly good stimulant that I haven't heard of, though, this could have been backwards generalized to the amphetamine homologoue of pyrovalerone?
I sound wasted, don't I? If I an too gone to post useful information, mods just delete my posts.
I won't get into any synthesis details but I can think of a number of synthetic routes off the top of my head that could involve a virtually infinite set of precursor materials. What is this drug like in the experience of those who have taken it?
Is there anything peer reviewed written about it?MDPVagrant
Bluelighter
The latter looks interesting, *except* for the notion of its involvement with opiate receptors (the latter would likely kill it for me, as even the slightest tinge of opioid agonism destroys my sex drive... the boosting of which is probably 90% of the reason I enjoy stims). Interesting that it's Schedule IV in the USA too, and unfortunate it's not nearly as available as crappy ol' alprazolam...fastandbulbous said:Prolintane is good stuff - even gives a weird sort of munchies! Only had it a few times, but is well woth persuing IMO (although not as much as fencamfamine, but then what is?
)
Last edited:
hussness
Bluelighter
I can dig up the reference for you, but I'm quite sure the proposition that fencamfamine's pharmacological profile involves mu agonism is flawed. It is based on the experimental observation that experimental animals, when treated with naloxone and fencamfamine, do not display the increases in locomotor activity characteristic of stimulants. This is likely due to naloxone's effects as an (idirect?) DA atagonist. I'm been tossing around the idea of proposing fencamfamine for my ADHD treatment, since methylphenidate, strattera, and adderall haven't worked that well, and it's only schedule 4. Does anyone know what it's on the market in the US for anyway, if anything?
Going back to MDPVagrant said earlier, I have noticed that as I've grown older interest in the stimulant high has attentuated. I don't think it's burn-out either, since quantitatively I haven't use very much drugs. I wonder if it's maturity or what, but stimulants don't seem to bring me to the point of being totally manic anymore (which is both good and bad).MDPVagrant
Bluelighter
^^ Could be you've just come to appreciate peace of mind as you've gotten older, rather than feelings of being wound up and such (and perhaps have used lesser amount of stims for shorter time periods? That would explain them being less likely to make you manic).
I seem to be reacting strangely to just about everything lately... for example, doses of kratom I used to take when I had a tolerance to it aren't doing anything for me now (with no tolerance), and same thing with tramadol... high doses hardly affect me. Stimulant-wise, I've felt a bit manic-y and hypersexual without getting near anything, but at the same time I still appear to have some long-term tolerance built up.
No clue what's going on in my brain/body these days in terms of substances... probably nothing good. Can a person's liver become more efficient at processing toxins, due to processing them regularly? LOL...Last edited:
hussness
Bluelighter
MDPVagrant said:
Yes, the human liver is capable of upregulating transcription/production of certain exzymes or cells in response to stress. If you've ever had a standard hepatic screeen, you've probably seen AST and ALT levels. Those stand for Aspartate-aminotransferase and Alanine-aminotransferase, respectively. The liver is remarkably resilient to stress from the xenobiotics people regularly ingest. Usually where you run into trouble is if you ingest a drug that causes permanent damage somewhere (usually in the brain), or chronic exposure -- like alcoholics.MDPVagrant
Bluelighter
^^ I wouldn't be surprised if that were the cause, then, as I seem to have developed a "tolerance" to just about everything... in other words, gone from a 'low-middleweight' to 'heavyweight' in terms of amounts consumed. Bit hard on the pocketbook, unfortunately
.
hussness
Bluelighter
My impression is that the mebabolism of only very select drugs is upregulated significantly by chronic exposure. I think current science still tends to favor the idea that a lot of the the tolerance effects from chronic use of certain recreational drugs (especially stimulants) is due to downregulation of reward pathways in the CNS. The former is a pharmacokinetic homeostatic mechanism, while the latter is a pharamacodynamic homeostatic mechanism.MDPVagrant
Bluelighter
Compounds similar to MDPV?
Are any of these compounds similar enough to MDPV that they would either be likely to produce similar observed effects in primates or have been demonstrated to do so? (Note, IUPAC data may read "1-ylpent" i.e. the yl is run together with the data after it).
IUPAC: (2R)-1-(4-methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one
IUPAC: (2S)-1-(4-methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one
IUPAC: (2S)-1-(4-methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one hydrochloride
IUPAC: (2R)-1-(4-methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one hydrochloride
IUPAC: 1-(4-methylphenyl)-2-pyrrolidin-1-yl-propan-1-one
IUPAC: 1-(4-methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one hydrochloride
IUPAC: 1-phenyl-2-piperidin-1-yl-pent-4-en-1-one
EDIT - ADDITIONS #1:
IUPAC: 2-hydroxy-N'-(2-oxoindol-3-yl)-2-propylpentanehydrazide
IUPAC: 1-(4-methylphenyl)-3-pyrrolidin-1-yl-pentan-1-one
IUPAC: (2S)-1-phenyl-2-piperidin-1-ylpent-4-en-1-one
For those who may be interested, there are other similarities here:
http://www.ncbi.nlm.nih.gov/sites/e...d.Pccompound_ResultsPanel.Pccompound_RVDocSum
P.S. please excuse my ignorance, I'm not too familiar with substances related to alpha-pyrrolidinopropiophenone. TIA!Someone really liked his pyrovalerone analog
I suppose that it has been mentioned before as this forum seams to have some very "skilled in the art" participants, but there was a paper J. Med. Chem. 2006, 49, 1420-1432 covering a lot of pyrovalerone analogs. For thoose without access to scientific publications the same information can be found in the corresponding patent, WO2005034878. http://www.wipo.int/portal/index.html.en
As a longtime reader (I belive the term might be lurker) I would also like to congratulate the moderators and posters on a forum thats well worth reading.
I really hope the this thread will be as good/fun as "stims of the future"
Wasted_Youth_HHT
Bluelighter
- Joined
- Jul 28, 2006
- Messages
- 83
for me no matter how much MDPV i had, i would almost uncontrollably keep redosing every hour until it had all gone. I worked out not to order more than 500mg at a time or i knew just how destroyed id be a week or so on. With all the stims ive tried ive found sleep posible with enough concentration, however probably not the kind of sleep that fully recharges the body, its a strange kind of sleep.MDPVagrant
Bluelighter
Thank you very much!Ahrrg said:Someone really liked his pyrovalerone analog
I suppose that it has been mentioned before as this forum seams to have some very "skilled in the art" participants, but there was a paper J. Med. Chem. 2006, 49, 1420-1432 covering a lot of pyrovalerone analogs. For thoose without access to scientific publications the same information can be found in the corresponding patent, WO2005034878. http://www.wipo.int/portal/index.html.en
THANKS! Dang, I've been wanting to read that one forever...almost- said:
Fwiw there are ways to control compulsive substance use, but none of them include willpower, determination, etc (IME obvious non-functional nonsense when it comes to compulsive substances).Wasted_Youth_HHT said:
For example -- with MDPV, I've found Seroquel to be highly effective. Even low doses are effective, as it seems to have a much stronger effect with MDPV co-present in the bloodstream (not sure if it's related to liver enzymes, brain chemistry or what). IME it's very nearly the perfect 'MDPV-killer' - wipes out the high (almost impossible to overcome by dosing more), strong calming effect, causes drowsiness, increases appetite. The only 'trick' is making the decision and actually popping the pills, which isn't always as easy as it sounds... but it's aided by the general impulsive nature of dopaminergic stimulants. Once the pills are in the body, nothing further is required... eventually the effects "force you into bed." Seems to work even better with some psychological resistance present.
P.S. I'm not sure Seroquel would be as effective for everyone, and I suspect people would need to find what works best for them. As long as one realizes the utter uselessness of 'willpower', there's always a chance of discovering what DOES work. As always, knowledge=power.Last edited:
Riemann Zeta
Bluelighter
MDPV experiences seem to vary dramatically between subjects. I never had a desire to redose; most of the time, I regretted dosing in the first place--it just didn't seem like it was worth putting up with the annoying sides. I grew to feel this way about methylphenidate after a while as well. Maybe I just don't like dopamine reuptake inhibitors. But I'd still like to try something like desoxypipradrol, as part of the problem with the dopamine reuptake inhibitors I've tried is their short half-life and a quick, fatiguing crash.Last edited:MDPVagrant
Bluelighter
Unless you're absolutely sure you'll stop at one dose, I wouldn't mess with desoxypipradrol... IMO the stuff is dangerous around people who tend to start using compulsively. That crazy-long half-life + duration of effects is no joke... use too much inside a certain time frame and you're in serious trouble.Riemann Zeta said:
P.S. unfortunately I'm speaking from experience, but IMO the combination of very long half-life + dopaminergic activity should make every thinking person nervous. I'd suggest insufflating or plugging if you do decide to try it, as it's very difficult to get the dose right orally (and re-dosing is risky).Last edited:
Riemann Zeta
Bluelighter
I'm not a particularly big re-doser when it comes to stims. Once I hit the desired level of tweakage to cut through the dissociative ADD "brain fog" (that's a technical term
) without major side effects, I stick with it. I would think that a long half-life would make people less likely to redose than a short half-life, as there wouldn't be a roller-coaster up/crash effect. The warning about oral dosing does make me think twice, however. I hate chemicals that are difficult to dose orally (engendering either no effect or too much effect with annoying sides). In addition, plugging is just definitely not for me--I don't want to be anal about this, but it sounds like a real pain in the ass, no ifs ands or buts .
fastandbulbous
Bluelight Crew
Never made me nervous and I'd tried doses all the way up to 30mg (which I must say IS NOT recommended). Ever considered that your reaction to it was fairly unique to you as most people don't think of it in such negative terms?
Also as Riemann Zeta has mentioned, the slow decline makes it not subject one to the crash seen with the shorter acting dopaminergics, but provides a slow, gradual decent without the subsequent depression. That said, anybody using it has to be aware that the mind/body requires sleep and that staying awake for days on end, just because you can by redosing is a very bad idea as it does lead into a sleep deprivation sort of craziness if not given the respect it deservesDesoxypipradrol seams to be gaining in popularity and availability. Although I don't have any empirical experience, by the descriptions you guys provides it sounds like a useful thing to have for long workhours.
What suprises me a little is that there is no particular logic behind which stimulants that become popular, e.g. the common as gras bzp that is easily produced and much better on paper than in reality to MDPV (although rare these days) that is fairly complex and quite an imaginative thing to bring foreward. Pemoline analogs would have been my guess, but then again almost every antidepresant SAR studie that is puplished seams to have at least one compound that have intersting characteristics. Unfortunaley thoose will probably only be seen by some late working grad-student.
On another subject is there any news on the earlier discussed 2-Diphenylmethylpyrrolidine?Last edited:
