Noopept Subthread
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N-phenylacetyl-L-prolylglycine ethyl ester
ANNOUNCEMENT
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wiki:
Noopept (Russian: Ноопепт; GVS-111, N-phenylacetyl-L-prolylglycine ethyl ester) is a medication promoted and prescribed in Russia and neighbouring countries as a nootropic. The registered brand name Noopept® (Ноопепт) is trademarked by the manufacturer JSC LEKKO Pharmaceuticals. The compound is patented in both the US and Russia. Patent of Russian Federation number 2119496, US Patent number 5,439,930 issued 8/8/1995.
It is derived from the racetam family of drugs and shares similar mechanisms of action, but is, according to studies, 1000 times more potent than the prototypical racetam drug, piracetam. Animal studies have shown noopept to be neuroprotective and enhance memory in various tests. Unusually for a peptide-derived compound, noopept displays both high oral bioavailability and good blood–brain barrier penetration in rats (although a previous study concluded that "GVS-111 itself was not found in rat brain 1 h after 5 mg/kg i.p. administration up to limit of detection" and that administration of Noopept only increases the concentration of endogenous nootropic Cyclo-L-prolylglycine), and human studies have shown promising results, with potential application in the treatment of Alzheimer's disease. It is also an "immunocorrector" in mice.
It has been found to stimulate the expression of NGF and BDNF in rat hippocampus. Expression of the studied neurotropic factors in the cerebral cortex was below the control after single administration of Noopept, while chronic administration caused a slight increase in BDNF expression. In the hippocampus, expression of mRNA for both neurotrophins increased after acute administration of Noopept. Chronic treatment with Noopept was not followed by the development of tolerance, but even potentiated the neurotrophic effect.
I have been taking noopept for about 2 months now, when I started it was no more than a day a week when I wanted to give it a shot experimenting. Then I gradually increased my intake to perhaps 5 times a week where I am now. I take 10 mg in the early afternoon but have also occasionally dosed twice. Basically I use it to optimize concentration and learning, practicing playing the piano (I play hours a day when I can) and pencak which is an indo martial art that requires agility, rapid reaction, balance and focus.
When I started I took the noopept orally, then switched to sublingual. I am not sure this improves because the musky taste lingers. Also, I don't understand how an oligopeptide like this can survive the digestive process. I was under the impression that proteins are disassembled into amino acids. No one seems to want to comment on this or explain that perhaps proteins only get chopped into oligopeptides but not smaller.
Also, with every considerable nootropic I use choline (bitatrate now, citrate before).
Right about now I may be building enough experience with it to say a few things about it. Similar to the racetams, I notice effects pretty fast after taking a dose but don't feel like there is a comedown that either bums me out or makes me notice that my abilities are getting diminished, urging me to redose. I think I benefit from nootropics but don't care that much if I can't or don't take them.
Noopept makes me feel like streams of information are rushing at top speed, mental stimulation when it comes on but no physical stimulation. There is less anxiolysis than aniracetam. The speeding stimuli and apparent improvements at the piano (which is one of the most tangible benchmarks for me) make it seem like noopept is superior to aniracetam but aniracetam seems superior in balancing out minor side-effects. It actually makes me more comfortable because I seem better equipped to handle the cognitive boost, better equipped to process information in general actually which seems one of the biggest things that calm me down. Noopept does not have this, it merely makes me okay with the boost but I am not that sure about netto improvement with anxiety or confusion.
Actually I took aniracetam yesterday before training and I had not taken it in a while. I was suprised by the beneficial effects and very impressed. After another comparison I doubt I will get a big stash of noopept, especially with the bulk aniracetam lying around. Though until my gram of noopept is finished I will probably keep taking it and might combo with the aniracetam soon for training.
You are all welcome to share, and when there is time the Big & Dandy Nootropics Thread should be reorganized to fill this.
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