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N&PD Moderators: Skorpio | someguyontheinternet
NMDA antagonists for tolerance, a collection of the evidence and anecdotal reports
- Thread starter MeDieViL
- Start date
DXM is.....well.....DXM.....i'll leave it at that
My DXM experiment was not successful in reducing my mdma tolerance. In fact, it may have had the opposite effect.
About 5 weeks ago, I did 7 days of 60 mg DXM HBr-- twice per day.
Used mdma one night, this last weekend. Hadn't used in nearly 3 months. Before that, rolled twice in three month span. This experience was in the bottom 3 of all time for me. Oddly, it seems that crappy rolls happen with longer breaks for me.
I started with 145 mg, two hours later barely felt it. Then took another 100 mg. Then at +2.5, insufflated approx 50 mg, took another 50 mg orally. Started to feel the foggy comeup, which lasted about an hour. Smoked one hit of sativa, downed a redbull. Felt little *tiny* bits of euphoria here and there. Ate more pills over the next 4 hours. I don't know how many. So much so that I had a tweaky leg for the next 24 hours... Chasing a high that I don't think I'll ever be able to catch again.
Before and after the DXM treatment, I did lightly use alcohol and moderately used marijuana. Also, took some benzos for sleep two or three times.
Material was personally tested marquis/mecke/simmons, and worked great for other people.
Perhaps the DXM benefit is not long-lasting? I did notice that pot, especially indica strains, seemed a lot stronger in the three weeks after DXM. And I definitely felt some effect of DXM during and for the few days after taking it. Once I pushed through the sluggishness, I felt a boost in self confidence and the whole world looked and sounded brighter. I really thought this was going to work. Very bummed. Definitely hung over, and feeling stupid.
About 5 weeks ago, I did 7 days of 60 mg DXM HBr-- twice per day.
Used mdma one night, this last weekend. Hadn't used in nearly 3 months. Before that, rolled twice in three month span. This experience was in the bottom 3 of all time for me. Oddly, it seems that crappy rolls happen with longer breaks for me.
I started with 145 mg, two hours later barely felt it. Then took another 100 mg. Then at +2.5, insufflated approx 50 mg, took another 50 mg orally. Started to feel the foggy comeup, which lasted about an hour. Smoked one hit of sativa, downed a redbull. Felt little *tiny* bits of euphoria here and there. Ate more pills over the next 4 hours. I don't know how many. So much so that I had a tweaky leg for the next 24 hours... Chasing a high that I don't think I'll ever be able to catch again.
Before and after the DXM treatment, I did lightly use alcohol and moderately used marijuana. Also, took some benzos for sleep two or three times.
Material was personally tested marquis/mecke/simmons, and worked great for other people.
Perhaps the DXM benefit is not long-lasting? I did notice that pot, especially indica strains, seemed a lot stronger in the three weeks after DXM. And I definitely felt some effect of DXM during and for the few days after taking it. Once I pushed through the sluggishness, I felt a boost in self confidence and the whole world looked and sounded brighter. I really thought this was going to work. Very bummed. Definitely hung over, and feeling stupid.
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It's difficult to be objective - but, I'll try... Used for a few years. Initial honeymoon period ~ once every three weeks. Several +2 month breaks and one 3 month break. Generally about once a month. Oddly, used way too much on occasions where it didn't "work", I'm talking close to a gram. Usually, when I was a good boy, I took between 275mg - 500 mg per night. Haven't had a truly "Magical" experience with mdma since those first 6 months. Man, they were amazing! Have had some cool combos over last two years (2CB, Psilo, K).
Have found that a higher dose up front (200+mg), followed by small boosts (1 or 2) is much better than building up slowly. But, when trying these various regimens (SJW, DXM, 5-HTP, L-Tyrosine, Piracetam) I'm very nervous about taking too much up front -- I did 200mg once with Piracetam and got floored and panicked on the come up. In this last case, after the DXM deal, having read that people had experienced a dramatic reduction in tolerance, I started with too low a dose.
Such a frustrating little puzzle, this tolerance is. Feel really amazing emotionally yesterday and today. The love is there, the connectedness... those components I consider magical, they're delayed and uncoupled from the stimulant components.
I would say that my material was weak (again, it was tested personally with the big three) but the hangover I got was so severe...
Is there a model for DXM tolerance reduction/reversal/whatever that would account for a temporary tolerance reduction that "wears off" after a month?
Much thx to report your negative experience, we also need negative reports to get a good objective view of the potential, it is possible you are one of the ppl that cant metabolise DXM correctly (it was somewhere posted in this thread) and therefor DXM wont work, or like in my case i didnt find DXM very effective for drug tolerance, altough i didnt try it long enough for stimulants, that was more my impression, i know it sucked for G tolerance tough while i had EXCELLENT results with memantine, i also remember magicalcat reporting that tolerance reversal went SLOWER when he added memantine to DXM, so it seem that ppl can respond differendly to nmda antagonists.
Yes for those that tried it so far it lowered tolerance and helped withdrawals.
MDMA didnt do enough tests to give a good answer and didnt take it enough, stims without a doubt, GBL without a doubt too, i took 100ml a week for several periods.
Behav Pharmacol. 2010 Feb;21(1):1-10.
Subchronic phencyclidine in rats: alterations in locomotor activity, maze performance, and GABA(A) receptor binding.
Beninger RJ, Beuk J, Banasikowski TJ, van Adel M, Boivin GA, Reynolds JN.
Centre for Neuroscience Studies, Queen's University, Kingston, Ontario K7L 3N6, Canada. [email protected]
Abstract
Phencyclidine (PCP), an antagonist at the N-methyl-D-aspartate subtype of ionotropic glutamatergic receptors, decreases gamma-aminobutyric acid (GABA)ergic inhibition, suggesting that changes in GABAergic receptor function underlie behavioral and cognitive deficits resulting from repeated administration of PCP. To test this hypothesis, male Sprague-Dawley rats treated with PCP (4.5 mg/kg, intraperitoneal, twice a day for 7 consecutive days) or saline were tested in behavioral and cognitive tasks 7 days after injections. The PCP group showed increased amphetamine (1.5 mg/kg)-stimulated locomotor activity, and exhibited a greater number of errors in the double Y-maze memory task, when compared with controls. Subchronic PCP treatment increased [H]muscimol-binding sites and decreased affinity for [H]muscimol binding in frontal cortex, hippocampus, and striatum in comparison with controls. There were no changes in the expression of glutamic acid decarboxylase or the GABA membrane transporter protein. These data show that subchronic PCP administration induces an impaired performance of a previously learned task and an enhanced response to amphetamine in the rat. The observed changes in GABAA receptors in the rat brain are consistent with the notion that alterations in GABAergic receptor function contribute to the behavioral and cognitive impairments associated with repeated exposure to PCP.
Subchronic phencyclidine in rats: alterations in locomotor activity, maze performance, and GABA(A) receptor binding.
Beninger RJ, Beuk J, Banasikowski TJ, van Adel M, Boivin GA, Reynolds JN.
Centre for Neuroscience Studies, Queen's University, Kingston, Ontario K7L 3N6, Canada. [email protected]
Abstract
Phencyclidine (PCP), an antagonist at the N-methyl-D-aspartate subtype of ionotropic glutamatergic receptors, decreases gamma-aminobutyric acid (GABA)ergic inhibition, suggesting that changes in GABAergic receptor function underlie behavioral and cognitive deficits resulting from repeated administration of PCP. To test this hypothesis, male Sprague-Dawley rats treated with PCP (4.5 mg/kg, intraperitoneal, twice a day for 7 consecutive days) or saline were tested in behavioral and cognitive tasks 7 days after injections. The PCP group showed increased amphetamine (1.5 mg/kg)-stimulated locomotor activity, and exhibited a greater number of errors in the double Y-maze memory task, when compared with controls. Subchronic PCP treatment increased [H]muscimol-binding sites and decreased affinity for [H]muscimol binding in frontal cortex, hippocampus, and striatum in comparison with controls. There were no changes in the expression of glutamic acid decarboxylase or the GABA membrane transporter protein. These data show that subchronic PCP administration induces an impaired performance of a previously learned task and an enhanced response to amphetamine in the rat. The observed changes in GABAA receptors in the rat brain are consistent with the notion that alterations in GABAergic receptor function contribute to the behavioral and cognitive impairments associated with repeated exposure to PCP.
tRANSLATION?
So my little trials:
DXM 30mg/morning, 60mg at night during 7 days.
Useless for GBL, I had a methylone experience and noticed no difference but I suspected the seller to give me weak mephedrone instead of methylone.
Useful for codeine tolerance, not in a fantastic way but it's a good help. I definitely add DXM to my tool box but just for a great potentiator for opiates because i'm an asthmatic and i had more difficulty breathing during my trial.
I'm gonna try to find some memantine, (and yeahh it's not a cold medicine!). Is there any danger with memantine use for an healthy man? For me, I lost "GBL magic" like you can loose MDMA magic (it's not the same at all but do you understand what i mean? You can take fucking breaks and tolerance don't move at all). I really hope that memantine will bring back the initial GBL euphoria that miss me sooo much. I love GBL and want a second chance to use it occasionally.
DXM 30mg/morning, 60mg at night during 7 days.
Useless for GBL, I had a methylone experience and noticed no difference but I suspected the seller to give me weak mephedrone instead of methylone.
Useful for codeine tolerance, not in a fantastic way but it's a good help. I definitely add DXM to my tool box but just for a great potentiator for opiates because i'm an asthmatic and i had more difficulty breathing during my trial.
I'm gonna try to find some memantine, (and yeahh it's not a cold medicine!). Is there any danger with memantine use for an healthy man? For me, I lost "GBL magic" like you can loose MDMA magic (it's not the same at all but do you understand what i mean? You can take fucking breaks and tolerance don't move at all). I really hope that memantine will bring back the initial GBL euphoria that miss me sooo much. I love GBL and want a second chance to use it occasionally.
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I also found DXM useless for GBL, but it does seem to work for stimulants, i retract what i said before, something else in my medication regime was inhibiting amphetamine.
Memantine on the other hand worked excellent for GBL tolerance, it also enhances the euphoria of ethanol, something everyone notices on memantine acutely and wich has never been reported with DXM.
Memantine is a well tolerated safe med, there are a few case reports of a slower heartrate tough with one person that died, however that is extremely rare, if you are worried get a heartrate monitor.
Memantine on the other hand worked excellent for GBL tolerance, it also enhances the euphoria of ethanol, something everyone notices on memantine acutely and wich has never been reported with DXM.
Memantine is a well tolerated safe med, there are a few case reports of a slower heartrate tough with one person that died, however that is extremely rare, if you are worried get a heartrate monitor.
Mate before memantine prevented loss of magic, but i ran out and lost it so i'm on the same quest to bring it back, i take around 100ml GBL a week (not physically addicted tough) lets hope for succes.
Couple of damn rats getting high on pcp and the noticing that their amphetamine is working better because their PCP abuse.
Its also interesting they note downregulation of GABAA in some area's and upregulation in other area's.
GBL took a while to have no euphoria (More than one year of sporadic use), i'm really interested to see if it will be the same after a mementine regimen. Is there any other potentials NMDA antagonists? I use to take magnesium, it helped a little bit when i suffered of anedonia thanks to GBL.
I mixed 60mg of DXM and tramadol (progressively 500mg in total) and i'm still alive but I don't recomend it to anyone... My body temperature was warm compare to tramadol alone (when i'm colder than normal, serotonine syndrome or placebo serotonine syndrome? I drank a few ricards too) I can't say if thit mix add some more, and won't do it again.
You said that mix piracetam and mementine synergise well don't you medieval (sorry for all the questions^^)? (i stoped my piracetam+choline mix for my first trial) Have a good night bluelighters!
I mixed 60mg of DXM and tramadol (progressively 500mg in total) and i'm still alive but I don't recomend it to anyone... My body temperature was warm compare to tramadol alone (when i'm colder than normal, serotonine syndrome or placebo serotonine syndrome? I drank a few ricards too) I can't say if thit mix add some more, and won't do it again.
You said that mix piracetam and mementine synergise well don't you medieval (sorry for all the questions^^)? (i stoped my piracetam+choline mix for my first trial) Have a good night bluelighters!
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