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NMDA antagonists for tolerance, a collection of the evidence and anecdotal reports

No good...will have to get back on the DXM but surprised it actually works while still taking the drug! Thanks to the OP!
 
MeDieViL,

On Memantine to address GBL tolerance.

Ive read the forum so far, but just wanted to clarify your opinion as to the best process...

On an individual who is already very GBL tolerant which has occured over a period of many years.
What would be the best reversal steps for using Memantine based on your experiences?

How fast would you expect results?

Would GBL consumption have to stop during the initial phase of taking it Memantine?
If so, for how long?

How long did you take Memantine before stopping?

When you talked about tolerance reappearing again, after memantine was stopped, could you guess how many mls of GBL it took to reappear?


Thanks!
 
I take 100ml of GBL a week, after memantine this turned into 250ml GBL + 300ml GHB a week (i buyed from my dealer if i ordered to late). Due to my strict timing regime i never encountered any physical dependency issues tough.

Memantine acutely potentiates alcohol euphoria alot, many ppl noticed this, i have no idea wheter you need to take a break or not, initiate memantine, go to around 30 mg if that doesnt work 40mg and initially keep taking GBL if tolerance does not change then stop it and take a break.
 
thikal said:
GBL took a while to have no euphoria (More than one year of sporadic use), i'm really interested to see if it will be the same after a mementine regimen. Is there any other potentials NMDA antagonists? I use to take magnesium, it helped a little bit when i suffered of anedonia thanks to GBL.

I mixed 60mg of DXM and tramadol (progressively 500mg in total) and i'm still alive but I don't recomend it to anyone... My body temperature was warm compare to tramadol alone (when i'm colder than normal, serotonine syndrome or placebo serotonine syndrome? I drank a few ricards too) I can't say if thit mix add some more, and won't do it again.

You said that mix piracetam and mementine synergise well don't you medieval (sorry for all the questions^^)? (i stoped my piracetam+choline mix for my first trial) Have a good night bluelighters! ;)
Click to expand...

They do synergize but regards to tolerance i have no idea, its possible piracetam abolishes the positive effects on tolerance.
 
Brain Res. 2002 Nov 8;954(2):151-9.
Valproate prevents the induction and the expression of MK-801 sensitization.
Yang PB, Swann AC, Dafny N.

Department of Neurobiology and Anatomy, The University of Texas Medical School at Houston, PO Box 20708, Houston, TX 77225, USA.
Abstract
Repeated administration of psychostimulants such as amphetamine, cocaine, and methylphenidate has been shown to induce behavioral sensitization. Sodium valproate, an anticonvulsant agent that enhances GABA activity, and dizocilpine (MK-801), a non-competitive NMDA receptor antagonist, can block the sensitization elicited by psychostimulants. MK-801 also has been demonstrated to sensitize to itself. The objective of the present study was to determine whether valproate disrupts the behavioral sensitization elicited by MK-801. Male Sprague-Dawley rats were given a regimen of repeated MK-801 injections (0.3 mg/kg, i.p.) that produced behavioral sensitization. They were also given valproate, at a dosage (50 mg/kg, i.p.) that prevented behavioral sensitization to stimulants, either during or after multiple MK-801 injections. After the washout period, animals were then re-challenged with MK-801 to determine whether valproate disrupted the behavioral sensitization elicited by MK-801. An activity monitoring system recorded horizontal activity, total distance, and vertical activity of the animals following drug treatment. Results of their locomotor responses demonstrated that valproate disrupted the development/induction and the expression of sensitization to MK-801, as it did to methylphenidate.
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Haha i wonder wheter memantine sensitizes to itself.
 
thanks for the translation ha...off to the chemist to get more robitussin tomorrow may get 3 bottles should last bout 15 days
 
Has anyone seen much success in using memantine to reduce benzo tolerance? It's been working great for stimulants, but at 20mg a day it doesn't seem to put a dent in my Valium tolerance.
 
I'm really unsure why memantine completely blocked gbl tolerance and dxm doesnt do a THING for it, i'm pretty much completely tolerant now, just get some sedation and a slight mood boost.

I saw a study how nmda antagonist number 1 prevented tolerance to social defeat induced tolerance too while number 2 didnt, however both worked for normal tolerance, so they behave differendly.
 
I had an idea. It certainly wrong and incorrect but: Are endogenous opiates synergies with NDMA antagonists? If yes, maybe the fast antidepressant effect of Ketamine and DXM coming from this synergy.
 
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thikal said:
I had an idea. It certainly wrong and incorrect but: Are endogenous opiates synergise with NDMA antagonists? If yes, maybe the fast antidepressant effet of Ketamine and DXM coming from this synergie.
Click to expand...

Doubtfull as the antidepressant effect remains after agonism, the antidepressant effects have been associated with synaptogenesis but that isnt the full story, if it was we wouldnt have to redose every week, but couldnt give a shit, better then taking shitty ssri's everyday.
 
I really want someone to try GBL with memantine and confirm my experiences with regards to tolerance.
 
My next test is phenibut with memantine, would be interesting if it blocks tolerance to this stuff wich has insane tolerance issues on its own.

I'm expecting it to block tolerance and also actually did see a positive anecdotal report but it was really vague, just something like "it prevents tolerance to everything i take, so i can keep taking phenibut without problems", or something like that.
 
J Thromb Haemost. 2008 Oct;6(10):1685-92. Epub 2008 Jul 18.
Treatment with dextromethorphan improves endothelial function, inflammation and oxidative stress in male heavy smokers.
Liu PY, Lin CC, Tsai WC, Li YH, Lin LJ, Shi GY, Hong JS, Chen JH, Wu HL.
Source
Division of Cardiology, Department of Internal Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Abstract
BACKGROUND:
Dextromethorphan (DM) is reported to reduce the inflammation-mediated degeneration of dopaminergic neurons.

OBJECTIVE:
The goal of this study was to test if DM can improve the endothelial dysfunction and inflammatory markers in heavy smokers.

PATIENTS AND METHODS:
Forty habitual smoking healthy male volunteers (mean age, 31.5 +/- 1.4 years) were randomly given either DM (120 mg day(-1)) or a placebo for 6 months. We determined endothelial function using the brachial artery diameter changes in flow-mediated dilatation (FMD) and measured their inflammatory and oxidative markers. A sex-and-age matched non-smoking group (n = 20) was compared as normal parameters.

RESULTS:
Habitual smokers showed impaired baseline endothelial function in FMD (smoking vs. non-smoking: 6.3 +/- 1.8 vs. 10.2 +/- 2.3% respectively, P < 0.01). Without change in smoking behavior, lipid and metabolic parameters, a significant increase in FMD was found in the DM-treated group (32%), accompanied by a decrease in high-sensitivity C-reactive protein (hs-CRP), phospholipase A(2), matrix metalloproteinase-3, interleukin 6 (IL-6) and tumor necrosis factor-alpha receptor II (TNF-alpha RII) (all P < 0.05), but unchanged in von Willebrand factor (VWF)and plasminogen activator inhibitor-1 (PAI-1). An increase in plasma glutathione peroxidase and a decrease in spot urinary excretion of 8-epi-prostaglandin F(2a) were found in DM-treated smokers.

CONCLUSIONS:
Our study suggests that a 6-month treatment with DM can improve endothelial function and attenuate vascular oxidative stress and inflammation markers in habitual smokers.
 
MeDieViL said:
I really want someone to try GBL with memantine and confirm my experiences with regards to tolerance.
Click to expand...

I'm waiting my order, ordered yesterday so wait a few weeks! ;) Thanks for your explanations of my false "theorie"! :D

I'm planning to do this:
- Stop taking piracetam (i will try the piracetam+memantine combination in an other trial to see if piracetam have an impact)
- Take magnesium daily, rhodiolia rosea when i need a little more concentration
- First week: 5mg/day mementine
- 2 week: 2x5md/day memantine
- 3 week: 15mg/day Memantine
- 4 week: 20mg/day memantine
- 5 week: 30mg/day memantine
- 6 week: 40 mg/day memantine
- 7week: End of the supply, see if it worked and maybe buy some more!

At the second or third week i will pass my exams. I really don't want my mind to be fogged. Is dosage enough progressive to lessen the side effects?

I've got huge tolerance to GBL euphoria. Took some last week and still have nothing but a fucking lethargic mood^^ I've little to medium tolerance to codeine (thanks to DXM), will see if memantine affect tramadol tolerance too. Might take MDMA or methylone in a few weeks, i'm really interested by St John Wort. Maybe i'll try it too!
 
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