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NMDA antagonists for tolerance, a collection of the evidence and anecdotal reports

Don't have time to read through all the posts but saw someone mentioned dxm reversing benzo tolerance & people using it for withdrawals or to stop withdrawals?? Does this work & what is the recommended dosage?
 
Dunno said:
Don't have time to read through all the posts but saw someone mentioned dxm reversing benzo tolerance & people using it for withdrawals or to stop withdrawals?? Does this work & what is the recommended dosage?
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It seems to work well for those that are trying it, 60mg twice a day.
 
Cool thanks i will give it a go as i'm trying to reduce my dosage and hopefully get off these stupid things.

So 120mg of DXM a day?
 
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I know everyone is different but just on average how many days would it take for it to lower tolerance?
 
A couple more reports.

I have been using dxm with oxy in a taper to help. Usually in wd I'm so god damn lathargic I get nothing done at all. The dxm stimulates me to the point of being normal if not better than.

In the morning on my way to work ill dose with dxm and somehow not have any wd symptoms. I'm hoping to taper down to at least 20mg before CT and then use dxm for a couple days. Ill be sure to report back.
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This works for me really well.

The only problem is getting that much DXM, as I get mine from the pharm. Extracting that much is pretty annoying.
WHen im tripped out on DXM the bodily aspect of the withdrawals still seem to be there but I just dont give a damn. It sure dosnt help me sleep but it's wayy better than tossing around, sweating like hell and feeling depressed and shit. When I get a high enough dose, usually around 800-900 twice a day, 3 days of nasty wds go by soo fast.
It helps tremendously with the depression aspect of the wds too, cuz for me I get alot of motion and music euphoria from DXM, so listening to loud music + jogging = me happy. Almost makes me want to go to a rave. So basically after two to three days of heavy DXM therapy Im pretty much back to normal.

I love DXM!
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Hi all,

After some serious problems with Oxy and Bupe, im free from opiates. it was kinda simple in the end. from 300-800mg oxy most days, then 10mg bupe day 1 with 500mg Dxm (it was a bad day) and 2mg xanax. Next day 2mg bupe plus 1000mg dxm. days 3,4,5 with 2mg Bupe 1500mg of DXM and 2mg Xanax. Day 6, 7 1000mg dxm and no bupe, xanax to taste with only 10 left. finished the rest of the DXM off (started with 25 500mg capsules) and the xanax over 7 days and then nothing. 1st night no sleep and desperate for something, but defenitely no sickness, no throwing up. Writing and drawing (things i dont normally do) helped thru the bad parts.

]
does anyone else have good experience in this way? I found theres no withdrawal (for me at least) no matter how high you go, just boredom when the closed eye visuals stop
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same guy:
totally this works for me so well its almost too easy. the first days always gonna be unsettling but the DXM makes it very introspective and instead of watching the clock and 10 mins seeming to take forever to go by, the time goes quick and can generally be spent lying on the couch and watching cool patterns and visions form behind your eyes. (of course they dissappear if you take too much xanax.) i used this before to get off methadone, without suboxone about 5 years back. generally once you know the amount of dxm you can take without flipping out but enjoying the effects, you can settle on that dose about twice a day. that could be as little as 200mg in the past, but there is an effect that causes the neurons to protect themselves (possibily to prevent Olneys lesionss) and after a while dxm becomes ineffective in some of the more fun ways or you gotta dose up more. Ive never found one withdrawal symptom from this drug except boredom, even for months at a time daily dosing. tho it will make you slurr your speech and look really messed up. And its actually not that hard to get in an easy to take form, if you do your research. (no sluggin back bottles of cough syrup needed)

i find that the effects resemble ketamine in the peak, and there is known to be cross tolerance from ketamine. Defenitely it feels like your body is anaesthetized and your legs get that oh so sweet relief, no restless legs. In the end its just what ive found out for me over the last ten years. be happy to share more on it
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Ket for GBL withdrawals:
^ I disagree. Works absolute wonders for me. Admittedly I have fairly minor G w/d anyway but ketamine kicks any w/d from anything I've ever come across to one side so far. Kinda like insta-ibogaine only cheaper and easier to get hold of.
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crOOk said:
Seems to work fine, tolerance has levelled out, I'm at a slightly lower amp dose than I was when I started, while before that tolerance was constantly increasing. I'm taking 30-60mg DXM 1-3times per week so far, along with my amp dose and a fat dose of Magnesium (eyeballed).

The following is an article from 2001, so it's not really up-to-date, but still offers some help in understanding the mechanism of nmda-antagonists antidepressant effects and possibly their tolerance decreasing effects as well.


In short: There are 3 genes that are highly expressed (suggesting they contribute to the developement of those neurons) in developing neurons of the newborn's brain. These genes are downregulated by NMDA receptor activity!

While two of these 3 genes were unknown when this was published, the third seems to be the equivalent to a gene found in yeast, that is responsible for inducing the G0 phase of cells. G0 is the phase were cells will not devide themselves any further.

It still doesn't make sense to me, but this sure is helpful.

On another note: Ethanol use seems to have an upregulating influence on NR2b gene transcription. An epigenetic mechanism is suggested here.
Booze->More NMDA 2b receptors

Btw looking at how I've developed a form of tolerance to some drugs, specifically dissociatives and psychedelics, these were much more persistant, less quickly reversible than say pot tolerance. Epigenetic mechanisms?

The epigenetic mechanisms referred to are, you've probably guessed it, methylation and demethylation of CpG sites in the regulatory areas of the mentioned gene. (Methylation of C5 in Cytosine; CpG=Cytidine+phosphate+Guanosin, one of the sequences in our dna/rna; Regions that enhance or silence expression of a gene are usually very rich in these CG-sequences and methylation of Cytosine in position 5 is thought to block these enhancing or silencing function by preventing the responsible specific transcription activators to bind to them).

And indeed it could be shown that booze induced demethylation of these areas, thereby enabling increased occupation of these DNA-binding sites and in consequence increased transcription of the NR2b gen, leading to higher density of NMDA 2b receptors.

Here's the publication:

I think this one is free. For the other one feel free to write me.
http://tinyurl.com/mightbefreedontknow
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Interesting post
 
^^Shit, looks like they took massive doses of DXM though. Would it still do anything at 120mg a day? Day 2 so far

I really hope this works..My DXM trippin days are over doesn't effect me anymore but even two cups of 10mls which equals 60mgs tastes like shit!!!!!!!!!! I'd hate to drink 1000mgs fuck!!! LOL!!
 
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Dunno said:
^^Shit, looks like they took massive doses of DXM though. Would it still do anything at 120mg a day? Day 2 so far

I really hope this works..My DXM trippin days are over doesn't effect me anymore but even two cups of 10mls which equals 60mgs tastes like shit!!!!!!!!!! I'd hate to drink 1000mgs fuck!!! LOL!!
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Mate, most ppl here tried those doses and it worked for them, give it a try;)
 
From Erowid:

DXM, as well as other dissociatives, seems to prevent and even reverse tolerance to (and thus physical addiction to) many drugs. In the case of opiates, DXM has been used to treat withdrawal symptoms (169). DXM plus diazepam (ValiumTM) was tested and found to be more effective at combating the symptoms of heroin withdrawal (goose flesh, tremors, pupil dilation, joint pains, etc.) than chlorpromazine (ThorazineTM) plus diazepam (34). A further study verified this and found that adding tizanidine (an alpha-2 adrenergic agonist) to the DXM+diazepam cocktail was even more effective (133).

Dissociatives have also been found to reverse or prevent tolerance to cocaine (247), nicotine (249), and alcohol (232), and some researchers have suggested that DXM (and other NMDA antagonists) may be universally useful in most if not all drug addictions.
 
Its a shame really they arent included the standard drug addiction treatments. Tolerance and withdrawals are the basic foundation of drug addiction.
 
True, well i have a high tolerance to xanax & have for around six years so hoping this works. Can't see it happening but see what happens
 
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