Niacinamide promotes Serotonin Synthesis, may help depletion?

[xapken]

Stumbled onto this while reading. Thinking it might help with Serotonin depletion from rolling. Pardon if this is commonly known, just struck me as interesting. Personally my interest in Niacinamide is anxiety and stress.

Journal of Orthomolecular Medicine Vol. 20, No. 3, 2005

Serotonin Synthesis

Another biochemical reason for niacinamide’s anxiolytic effects might have to do with the vital role that it has upon the synthesis of serotonin.

For example, in a patient with anorexia nervosa an insufficient supply of vitamin B3 or protein resulted in reduced urinary levels of the serotonin breakdown product, 5-hydroxy-indolacetic acid (5-HIAA).32 The authors of this report postulated that a deficiency of vitamin B3 reduced the feedback inhibition upon the kynurenine pathway, resulting in more tryptophan being diverted to the kynurenine pathway, making less substrate available for the synthesis of serotonin.

By contrast, the use of pharmacological doses of vitamin B3 can increase the production of serotonin.33 In a rat study, the administration of 20 mg of niacin resulted in increased levels of 5-HIAA and decreased levels of xanthurenic acid via the kynurenine pathway.34 Taking pharmacological doses of niacinamide (or any other form of vitamin B3) would increase the production of serotonin, by diverting more tryptophan to become substrate for serotonin synthesis. Niacinamide’s therapeutic ability to increase serotonin production might explain why it was successful in reducing the anxiety symptoms of the three patients

 

[PeacePipeChief]

Thanks for that information . I love how there's a thread asking if music sounds as good on Vicodin as it does on weed in OD , yet this is in BDD lol , regardless thanks gotta look into this .

 

[xapken]

Thanks for that information . I love how there's a thread asking if music sounds as good on Vicodin as it does on weed in OD , yet this is in BDD lol , regardless thanks gotta look into this .

Music is way better on DXM Don't they know this ? *grin*

Still learning my way around, pardon the mis-post.