I would say take about 20-30 mgs of done and that should be plenty for the tolerance you listed......i know my opiates rather well especially oxy, and methadone which you have mentioned hope that helps....and depending on the amount of mdones you are on you can still take the percs but sometimes the done's will block the effects of other opiates but i have done methadone and oxy many times and prefer it so i dont need as much oxy