RCs New RC-Benzos that Work as Prodrugs for Already Existing Ones (Clonazafone, Diclazafone, etc.)

[krkkhed]

Shit I literally am in a Canada and I still can’t get my hands on avizafone! Had to pay up the ass to get some actual diazepam and of course due to the yearly Christmas postal strike im still waiting an extra week for that to get here..

Btw @Dextro .45 ; would you mind kindly mentioning how similar avizafone dependency and withdrawals would be like compared to just taking actual diazepam ?

did you end up getting it? How was it? I am pretty sure I know where you got it and I'm thinking of ordering some myself when I go back to Canada next week to visit family. I'll be there for a while so I'll be able to wait for it to arrive. It seems decently priced if 22.5mg is equal to 10mg Diazepam.
I tried Rilmazafone before and it was very fun, very interesting benzo. Seems Avizafone is quite similar to Diazepam, which is good because I love Diazepam

 

[Dextro .45]

Avizafone (Pro-Diazepam) isn’t pretty similar to Diazepam…….IT IS Diazepam (once IM injected and enters the bloodstream, cleaving molecule into l-lysine and Diazepam (Valium)

Actually, Avizafone (Pro-Diazepam) is much more effective and rapid acting reaching C-Max significantly faster. This water soluable pro-drug is like Super Valium

 

[pcplease]

soma/prob simply are too unpredictable, we dont know well enough their mechanisms of action and acts on GABA in a strong potentially dangerous way.

they used to be prescribed very often w/ pain management bc they are incredible potentiators, possibly moreso than benzos

i am very interested in clonazafone. if avizafone really is super quick diazepam will get some. i assumed it would be, but reports seemed lackluster, but nowadays so many benzo users are used to bromazolams potency

 

[Dextro .45]

Avizafone (Pro-Diazepam)
Diclazepam (2-Chloro Diazepam) > Delorazepam >> Lorazepam
Etizolam
Deschloroetizolam

In Canada these amazing benzodiazepine analogs, pro drugs, RC, etc are absolutely fantastic w

Diclazepam (2-Chloro Diazepam) actually synthasized by the same polish chemist who made Valium, Librium, and Klonopin….is a very interesting compound. Longer acting than Diazepam……but more similar to Lorazepam (Ativan) . Diclazepam is metabolized into 3 genuine licensed benzodiazepines……most prominent being Delorazepam and finally metabolized into Lorazepam (Ativan)

Avizafone I have SC injected 50-70mg (pinch belly fat and poke insulin syringe in) 5-10min fast onset potent water soluble pro-drug rapid acting Diazepam (Valium) 22.5mg Avizafone is equal to 10mg Diazepam. I am 240lbs / 6’ male so usually need Valium 40-50mg for a robust safe dose (usually max for me)

Etizolam is simply amazing….I had probably 3,000 mg of pure powder and 1,500 mg of its analog - Deschloroetizolam, which believe it or not, is actually better than Etizolam lol no shit…..if you ever manage to procure pharmaceutical grade 100% pure Deschloroetizolam (think of Triazolam & Alprazolam) Xanax is obviously more pleasurable than its hypnotic analog Triazolam

10-15 years ago I had obscene amounts of a vast selection in my inventory …….fuuuuuuck, where did it all go lol

Diclazepam >Delorazepam>>Lorazepam (Ativan) 200+ hour half life is the ultimate taper benzodiazepine and amazingly potent long acting anxiolytic….3mg is my dose

Methadone 100-125mg
Diclazepam 3mg
Methylphenidate (Ritalin) 50-70mg IR
Pregabalin 300mg
(All taken together 4-5h after Shrooms or LSD 100ug) pure bliss

 

[pcplease]

i have a little over a gram of pink deschloroetizolam, which is very good, but the few grams of some white crystal identical to when etz2 came out that is perfect. i only have one old/reliable source for it (the one with pure white) and at 100usd/g i am guessing stock is probably low. even at that price, if i knew it was the last available i may be buying more.

mexazolam is a japanese prodrug for delorazepam and lorazepam

 

[canadianpeduser]

Actually….when I take Diclazepam 2-3mg I feel the subtle onset in 1.5 / 2 hours and then it gradually becomes more apparent

The REAL magic happens the next day…..due to its slow metabolism and 3 active metabolites being made active, the user will notice robust anxiolytic effects 2-3 days after…..even longer with daily steady dosing as it can build up to higher levels in bloodstream, which COULD be dangerous and lead to unsafe levels of Delorazepam & Lorazepam in the subject

I usually use mine in a Brompton Cocktail …..but it’s not the best suited compound for such thing. A rapid acting potent benzodiazepine with rapid clearance and fast metabolizing much safer

Diazepam (Valium) 10mg tablets is hands down the best benzodiazepine ever synthesized
Alprazolam (Xanax) 2mg bars are the second best anxiolytic & antidepressant compound

Yeah agreed. But the real brand name Valium. The white tablet with the “V” shaped hole in the middle was my fav ever. Kicked in within 5 mins felt amazing. Haven’t seen one since high school

 

[notsmokeymcpot42088]

mexolam prodrug for lorazepam good to know. Dextro -- when you say in CA does that mean they are illegal US?? or vendors just generally know better than to deal with americans as it leads to arrests -- they were legal to possess even skirted possible analog trouble last I checked.

We have hashed out the carved V vs. Diazepam 10,000 times. (same with the K klonopins). 10 mg Diazepam = 10mg Diazepam no matter what factory it came out of (AS LONG AS THEY PUT 10MG IN THERE, legally I think they could go as low as 9.8?) In the US currently unless its already been changed since trump got in. (Idk if that is FDA or?)

If the brand doesn't dissolve at the same rate that could cause slight fluctuation. Mainly placebo and cool factor. (anectdotal - ONCE I got morphine 30s IR, was already an addict and came to say "These are hitting way harder" was shot down (rightfully so-ish) than a couple months later a recall was issued saying they could contain up to 60mg and I felt vindicated)

The reason you haven't seen one since highshool (correct me if I am wrong) is because the 7 yr patent ran out ALONG TIME AGO hence noone is paying extra to stock the brand name. (I asked for the klonopins with the K once - they don't stock them here)

 

[canadianpeduser]

mexolam prodrug for lorazepam good to know.

We have hashed out the carved V vs. Diazepam 10,000 times. (same with the K klonopins). 10 mg Diazepam = 10mg Diazepam no matter what factory it came out of (AS LONG AS THEY PUT 10MG IN THERE, legally I think they could go as low as 9.8?) In the US currently unless its already been changed since trump got in. (Idk if that is FDA or?)

If the brand doesn't dissolve at the same rate that could cause slight fluctuation. Mainly placebo and cool factor. (anectdotal - ONCE I got morphine 30s IR, was already an addict and came to say "These are hitting way harder" was shot down (rightfully so-ish) than a couple months later a recall was issued saying they could contain up to 60mg and I felt vindicated)

The reason you haven't seen one since highshool (correct me if I am wrong) is because the 7 yr patent ran out ALONG TIME AGO hence noone is paying extra to stock the brand name. (I asked for the klonopins with the K once - they don't stock them here)

Well im pretty sure it was on Reddit somewhere I read recently by law generics are allowed to be 20% less potent. And I’ve been around long enough to have tried many, many different pills of all types brands, generic and pressed.

If you don’t believe there is any sort of discrepancy AT ALL between a brand name and certain generics of some drugs, im sorry sir but you’re wrong. And sorry I didn’t read your 10,000 times of discussing something, I just stated an experience I had. And it was wayyy more potent and effective than the blue APO 10 mg diazepam. lol you sound like my dr. “It’s all just psychological”, yeah that’s why some pills were pointless to try and shoot even when being water soluble compared to their brand name counterparts. Generic vs brand name is sometimes no difference, but a lot of the time it is. I had to play with the brands of my meds for years before I found the right ones that worked for me. And it’s now written right on my script bottles to ask for diff brands.

Like any dilly user knows the circle PMS dilaudid pales in comparison to the brand name PF triangles or even the APO triangles. Oxy is another one. Generic cheap lorazepam does next to nothing for my anxiety. Meanwhile the brand name has a giant difference for me.

I wouldn’t have even bothered to argue with you but you sounded snooty enough about it to try to give you some real life examples why you’re wrong .

 

[notsmokeymcpot42088]

you are correct it was either 2% or 20% (I went from memory and 2 sounded more logical) I concede that immediately. so 8mg 20% difference would become noticeable in higher dosages FORSURE -- Still capitalism and if anything (knowing the price of the powder) I would think I'd be more apt to go 11 than 9 if I was running a pharma biz.
----Use the search engine to see this argument play out 10k times.

You went Apples to Banana's when you started talking about water solubility. You must know that? Shooting is a whole different ballgame (What fillers are in the pill, ratio of active ingredient to binder, etc). OBVIOUSLY TIME RELEASE IS A DIFFERENT BALLGAME too.

Let me expand on what your doctor told you as I have more context; 10mg PO Diazepam = 10mg PO Diazepam and what you are experiencing is most likely psychological. Some added weight of confirmation bias of your dilly dalliances (which were valid).

I stand by my statement. (Not fully knowing what that % deviance is in Canada but pretty sure they didnt get it worse than us). If you are taking 8 10mgs at a time (I doubt doc factored that in) AND the pharma companies are shorting there pills than I will concede there is a possibility *Microscopic* you are correct. Pacebo is very real --- you are aware of setting affecting your buzz too hey? Take your normal recreational dose in a setting you usually do not and you will likely find an increased effect. (This is well documented)

I would not have bothered posting a reply but I did not want this thread to go in the direction of so many others -- sorry if I came off as snooty.

 

[canadianpeduser]

---

you are correct it was either 2% or 20% (I went from memory and 2 sounded more logical) I concede that immediately. so 8mg 20% difference would become noticeable in higher dosages FORSURE -- Still capitalism and if anything (knowing the price of the powder) I would think I'd be more apt to go 11 than 9 if I was running a pharma biz.
----Use the search engine to see this argument play out 10k times.

You went Apples to Banana's when you started talking about water solubility. You must know that? Shooting is a whole different ballgame (What fillers are in the pill, ratio of active ingredient to binder, etc). OBVIOUSLY TIME RELEASE IS A DIFFERENT BALLGAME too.

Let me expand on what your doctor told you as I have more context; 10mg PO Diazepam = 10mg PO Diazepam and what you are experiencing is most likely psychological. Some added weight of confirmation bias of your dilly dalliances (which were valid).

I stand by my statement. (Not fully knowing what that % deviance is in Canada but pretty sure they didnt get it worse than us). If you are taking 8 10mgs at a time (I doubt doc factored that in) AND the pharma companies are shorting there pills than I will concede there is a possibility *Microscopic* you are correct. Pacebo is very real --- you are aware of setting affecting your buzz too hey? Take your normal recreational dose in a setting you usually do not and you will likely find an increased effect. (This is well documented)

I would not have bothered posting a reply but I did not want this thread to go in the direction of so many others -- sorry if I came off as snooty.

I appreciate the maturity of your response.

Again I’ll give another example. Im prescribed 300 mg Quetiapine at night for sleep. If im given the PMS or the APO brand, they do next to nothing for me and I can’t sleep.

But when I asked for a certain brand with the arrow on the pill (generic brand name called Sivem pharma) , within an hour of dosing I get hungry and sleepy. Quite noticeable effect.

Another med I take is zopiclone for bed. If I take the APO brand i need 3 x 7.5 mg pills to be equivalent to 2 x TEVA 7.5 mg pills.

Generic companies may be close to- but they usually fall short of brand name. I actually prefer the generic TEVA zopiclone over the brand name Immovane. Ive been fucking with pharmaceuticals over half of my life. So I’d have to lean towards my own experience rather than what you’re implying. I also am not meaning to come off as rude towards you as I do not know you or really know your history on these boards.

Another medication I am prescribed is testosterone. The old Valeant Delatestryl runs circles around the Taro script i get now. I immediately felt the difference from the dela whereas now with Hikma who produces Delatestryl it’s like night and day, even though my T levels may be similar.

I now do my best to get the Pfizer depo test when I fill my script as it’s been the smoothest and most effective for me.

Back in the day when I dealt script opiates on the street, we even had different prices we would charge for generic vs pharma brand pills. In my area nobody cares for the generic percs with the numbers on them but will pay top dollar for the TECS.

There are differences that many people notice when they take these drugs long enough

 

[canadianpeduser]

in my hurtin low bottom junkie days i would highly prefer the brand name Wellbutrin over the generic. Another big difference I noticed when crushing , microwaving and scraping up the residue. It was very different to deal with and it would only yield about half of what the brand name pills would. Im not proud of those days but it’s all lived experience i guess now. Just glad I never shot them like some people I know with abscess scars on their arms and neck.

 

[canadianpeduser]

I merely brought up water solubility to further put forward the notion that generics are not equal to brand name

 

[notsmokeymcpot42088]

Ok the antidepressants are a solid enough metaphor for me... Do what you feel works best 100%. I do not recommend paying extra for brand name medications to those reading this. The microwave thing is interesting; that was welbutrin or crispin oxy's dilly's phine's? With the opi's I can see results varying greatly as there is such a small amount of active ingredient to begin with and unless you are pulling back pure active ingredient it is kind of a ?.

Regardless of what the pill was I guess I could ask are you sure you were pulling back 100% active ingredient and that is why the pile was double the size

Ppl here pay more for the teks too but it is because they have a lack of naloxone and the old "naloxone is what blocks other opi" myth exists and you can't talk reason with some people. I actually do remember one hydro/tylenol brand being a buck less on the street, Mallinkrodt(Sp) maybe -- or they were the good ones it has been a LONG time.

If you really really wanna prove it *you don't it would be silly* you could stockpile a bunch (like a gram of active, of namebrand v generics into powder and send em to a lab to see which comes back with more active ingredient.) I do not feel like you need to prove this point as everyone is different metabolism wise and batches may vary. Continue on I say and if anybody would like to throw in there experiences feel free.

*EDIT* Speaking of naloxone and quetiapine I think they may have a combo of those two substances marketed as something -- saw the commercial and went, why the hell would that be in there?? Official reason to combat weight gain (well what an odd choice) --- maybe it wasn't quetiapine but I thought it was seroquel -- in fact it is flagging it for bad combo so I must be wrong.

 

[Dextro .45]

Yeah agreed. But the real brand name Valium. The white tablet with the “V” shaped hole in the middle was my fav ever. Kicked in within 5 mins felt amazing. Haven’t seen one since high school

Roche branded Valium (Diazepam) 2mg white scored tablet - imprinted V / 2
Valium 5mg - yellow scored V
Valium 10mg - blue scored V

I too preferred branded Diazepam 10mg tablets ……ESPECIALLY Spanish KERN Diazepam 10mg tiny speckled light blue non-scored tablets imprinted 10 ……most POWERFUL Diazepam tablets ever……damn

Canadian generic Apo-Tex Diazepam 10mg are weak as shit …..pathetic garbage

Kern Diazepam 10mg tablets felt like I was shot with an elephant tranquilizer, the muscle relaxation had me all jello and sliding across hallways and bumping into walls …..3-4 tablets Max …..for a 240 lbs / 6’ male who has a tolerance

oral hybrid - Brompton Cocktail (my custom special for 10+ years)

Methadone 100-125mg
Methylphenidate (Ritalin) 50-70mg IR
Diazepam 20-30mg
Alprazolam 1mg
Pregabalin 300mg
Ethanol - Gin 2.oz X 3-4

All pulverized in same glass, drink, 30-45min onset / 1h peak …..enjoying Gin cocktails

The ultimate Brompton Cocktail

 

[SuperPsych]

I'm not sure if it's a prodrug, but has anyone tried bromonordiazepam? I recently acquired some and really want to try it. I've heard it can last multiple days and I also just started buprenorphine treatment again so I doubt that I'll have the chance any time soon. It's been a long time since I've had a good benzo high. I probably should have gotten something with a shorter half-life but this was too appealing. Also nervous about making bad decisions due to delusions of sobriety. Just lost my job partially due to meth use and am trying to get my life back together. I can see myself taking a dose of this, then 2 days later deciding on a whim to order some meth. Needless to say, I won't be trying bromonordiazepam for quite a while, but in the meantime I'm trying to learn what I can about it

 

[pcplease]

fda allows for something like 5% deviation from label claim, def not 20% , same standards/regulations apply to generics as brand name

 

[goaway12345]

Anyone have any info on Melex ? Mexazolam

Been searching all over the net and nothing.

 

[canadianpeduser]

Ok the antidepressants are a solid enough metaphor for me... Do what you feel works best 100%. I do not recommend paying extra for brand name medications to those reading this. The microwave thing is interesting; that was welbutrin or crispin oxy's dilly's phine's? With the opi's I can see results varying greatly as there is such a small amount of active ingredient to begin with and unless you are pulling back pure active ingredient it is kind of a ?.

Regardless of what the pill was I guess I could ask are you sure you were pulling back 100% active ingredient and that is why the pile was double the size

Ppl here pay more for the teks too but it is because they have a lack of naloxone and the old "naloxone is what blocks other opi" myth exists and you can't talk reason with some people. I actually do remember one hydro/tylenol brand being a buck less on the street, Mallinkrodt(Sp) maybe -- or they were the good ones it has been a LONG time.

If you really really wanna prove it *you don't it would be silly* you could stockpile a bunch (like a gram of active, of namebrand v generics into powder and send em to a lab to see which comes back with more active ingredient.) I do not feel like you need to prove this point as everyone is different metabolism wise and batches may vary. Continue on I say and if anybody would like to throw in there experiences feel free.

*EDIT* Speaking of naloxone and quetiapine I think they may have a combo of those two substances marketed as something -- saw the commercial and went, why the hell would that be in there?? Official reason to combat weight gain (well what an odd choice) --- maybe it wasn't quetiapine but I thought it was seroquel -- in fact it is flagging it for bad combo so I must be wrong.

Since when was there naloxone in and oxycodone product ? Tecs? Did I miss something important lol

fda allows for something like 5% deviation from label claim, def not 20% , same standards/regulations apply to generics as brand name

well I did read it on Reddit, which means whoever did post it quite possibly have been from a different country. But for some of my meds i have experienced a 20% decrease ineffectiveness. I can also agree that it’s not a blanket system for all drugs. But for some definitely effectivenesss and potency isn’t really cared for about by a lot of generic companies. I also believe they do put the same amount of drug in these generics, even the ones I was discussing earlier. But somehow with the way it breaks down in my system i experience a reduced potency. I’d have to do some personal digging to find the exact % on how less effective generics are meant to be.

I have one more personal experience to share. My Uncle is on meds for his Bipolar disorder . A couple of years ago his disability coverage changed and now he can only afford the generic version or whatever drug he was taking. And they don’t work. His major symptoms have been ruining his life since this happened

 

[Esperighanto]

I'm not sure if it's a prodrug, but has anyone tried bromonordiazepam? I recently acquired some and really want to try it. I've heard it can last multiple days and I also just started buprenorphine treatment again so I doubt that I'll have the chance any time soon. It's been a long time since I've had a good benzo high. I probably should have gotten something with a shorter half-life but this was too appealing. Also nervous about making bad decisions due to delusions of sobriety. Just lost my job partially due to meth use and am trying to get my life back together. I can see myself taking a dose of this, then 2 days later deciding on a whim to order some meth. Needless to say, I won't be trying bromonordiazepam for quite a while, but in the meantime I'm trying to learn what I can about it

I'm a huge fan of bromonordiazepam (I'll be abbreviating it to BND for the rest of this reply). BND takes an hour or two to fully come on, but it has a 3.5 day half-life and you feel it for essentially a full week. It's also weak as fuck, I'm talking so weak I've taken 50mg lines of it and not come even close to blacking out, on absolutely zero tolerance to anything benzo/gaba related. I also weigh 220-225 lbs (just over 100kg) though, and I'm the type who used to measure how much I drank by fifths or 40oz's, so maybe I've somewhat "gaba permatolerant" at this point. BND is a beautiful, beautiful drug, it takes diazepam's sedation away but leaves that euphoria that feels a lot like sun-on-skin contact on a day with a nice cool breeze, green grass, friends around and an apple cider in hand man, idk how to put it. It's just this feeling of perfection I've only ever felt from diazepam itself, except it lasts a goddamn full week.

If you are a habitually redose-y type, beware because it will amplify the absolute hell out of other benzos/gaba agents. I could see BND taken 4-5 days ago still making something like GHB (or its prodrugs) likely more dangerous, for example. If you're the type to "just have a few beers a night", cut it into 1/3 dose or 1/2 dose if you've used BND in the last week. Also even half a Soma 500 would black me out if I was within a few days of having taken BND, it made my old Soma stash last WAY longer. It doesn't create the intense "I don't give a fuck" quality that alprazolam can induce, it's MUCH more similar to diazepam, as far as the fact that it actually is a metabolite of diazepam.

Most people will claim BND "does nothing" after taking a single 2.5mg tablet and having a 12mg per day xan habit or some shit. It's mad goofy. BND is one of the most gentle, kind, caring benzodiazepines I've ever come across, it's like a warm hug from an old friend in a way that no other drug I've ever used really is. I hope you have fun with it!

 

[notsmokeymcpot42088]

Since when was there naloxone in and oxycodone product ? Tecs? Did I miss something important lol

well I did read it on Reddit, which means whoever did post it quite possibly have been from a different country. But for some of my meds i have experienced a 20% decrease ineffectiveness. I can also agree that it’s not a blanket system for all drugs. But for some definitely effectivenesss and potency isn’t really cared for about by a lot of generic companies. I also believe they do put the same amount of drug in these generics, even the ones I was discussing earlier. But somehow with the way it breaks down in my system i experience a reduced potency. I’d have to do some personal digging to find the exact % on how less effective generics are meant to be.

I have one more personal experience to share. My Uncle is on meds for his Bipolar disorder . A couple of years ago his disability coverage changed and now he can only afford the generic version or whatever drug he was taking. And they don’t work. His major symptoms have been ruining his life since this happened

*EDIT* Ran a quick google can't seem to find the legal deviation but got this "Bioequivalence is required (defined as the same plasma concentration over the same time of active ingredient) but there is still discussions whether they are truly interchangeable with certain medications in certain fields and people with certain medical conditions) -- Here you go this is "debunking that 20% claim" www.pharmacytimes.com/view/debunking-a-common-pharmacy-myth-the-80-125-bioequivalence-rule (I had to type that by hand lmk if it works) -- THAT LINK THE REST YOU PROBABLY DON'T NEED - MAYBE THE ADVICE FOR UNC!

I thought you meant subutex (Bupe with no naloxone) and I have never heard an oxy called a tek -- regional lingo differences perhaps? (Didn't you mention ppl pay extra for teks -- that is true with subutexs(sp) because it does not contain naloxone and myth is prevalent) If you meant something else by tek's regional misunderstanding.

I think reddit was correct this time I went from memory and 20 came to head first and I thought that seems a little large 2% is more logical. I was wrong.

20% variation is NOT PLAUSIBLE ABOUT 10% Max to pass regulation as the formula is not quite what we expected -- Butt -- maybe not? In mexico they short the pills out of pharms all the time and IMO US standards are certainly uhh slipping fast. It may be the FDA that enforces this (again memory not sure) if so that makes a little since. I would guess it is someone in the line diverting 1mg out of every 10 or w/e (would certainly cover your habit). In fairness I did mention different pills have different binders and may break down differently (I think, I meant to at least) and everyone has a different metabolism so I say go with what is working for you.

I am very sorry to hear about your uncles medication. Since he is your uncle maybe this is somekind of genetic anomaly/problem digesting/proccessing/allergy idk miniscule chance but worth note -- Does the pharmacy no longer stock the brand that works? Do no pharmacies in the area? I would call around and question logistics later honestly.....failing that I suppose I would ask if he crushes/chews or parachutes; SHOULD defeat any variation in digesting/processing the active ingredient.) --- IN FACT THIS FEELS LIKE the kind of thing he could probably tell his doctor?? Not much market for those nor much abuse potential. at any rate that feels like a solvable problem that should be worked at

IF YOU WANT TO PITCH THIS AS A RULE OF THUMB NOT ANOMALY than I would say pocket w/e is the highest mg and you can go without (You are already AMA im a bad influence) till you have a gram of active ingredient in both generic and brand name than send them to a lab to see which one contains more active ingredient. Of course the larger the sample of each the more accurate the data...

First question I would ask if you think it is rule of thumb level is "Would there be a way to turn a dollar without losing a dollar and one cent" -- If there is than you very well may be onto something they certainly have no scrupals. Personally unless it is a diversion scheme by someone working for them I would think it would be a money losing plan (which I could not imagine risking a pharma empire over but who knows--greed seems to know no bounds)