New Psychedelic Study with very interesting results

[any major dude]

This will definitely be a topic of conversation at the upcoming MAPS conference... It appears the 5ht2a receptor, commonly thought to be the main mediator of psychedelic effects, is not always all that important. I also posted a thread regarding this over in ADD, as I'm sure they'll have a field day with it as well, but it definitely falls into the realm of PD material too.

Psychedelics & the Human Receptorome

Of course these results will have to be replicated, but the implications right now are quite provocative.

 

[morbiddoctor]

I'm interested tonsee what happna with this. Nice post. Are you refering to the google MAPS conference? I would know if I had followed

 

[any major dude]

The Multidisciplinary Association for Psychedelic Studies conference in April in San Fran

 

[Al_S_Dee]

very interesting article. thanks.

 

[azzazza !?]

thanks for posting this. controversial results; mighty interesting. as Cegli in ADD already mentioned; the qualitative psychedelic effect in the mind may not be just a simple matter of linear receptor affinities in the brain. something i suspected for the longest time, though

 

[rickolasnice]

Someone wanna sum up the study for me?

 

[psood0nym]

azzazza: Yeah, I doubt many who have experienced the classical psychedelics as well as visionary drugs of other classes thought it was going to be that simple. Still, the purported selectivity was a nice objective marker (now, a convenient fiction) for classification and discussion. The findings on DOI may especially end up causing a stir, since it's been used for so much research.

Ironically, DOI has been one of the drugs of choice in studies of the molecular pharmacology of psychedelics, and has been widely assumed to be a 5-HT2-selective agent [4], [6], [7], [15], [16]. This study has revealed DOI to be one of the least selective of all psychedelics. Some of the literature on DOI may need to be reinterpreted. The same may be true of any studies whose conclusions rely on the assumption that psychedelics are selective.

Someone wanna sum up the study for me?

Abstract, intro and discussion sections are you're best bets until then.

 

[Roger&Me]

Interesting!

I always intuitively suspected that DOI wasn't a selective 5HT2A agonist. In fact, I doubt any psychedelics are. Psychedelia is a much more complicated neurochemical phenomenon than can be explained through discussing affinities for one receptor subtype.

 

[any major dude]

Interesting!

I always intuitively suspected that DOI wasn't a selective 5HT2A agonist. In fact, I doubt any psychedelics are. Psychedelia is a much more complicated neurochemical phenomenon than can be explained through discussing affinities for one receptor subtype.

agreed.

According to this study, 2c-e is seems to be the closest thing to a selective 5ht2a agonist, which is interesting, especially as its one of, if not my current favorite. It seems the ethylated (or ethylthiolated in the case of 2 & 4c-t-2) phenethyl, butyl, & amphet, amines have the highest affinity for 5ht2a receptor sites, which is interesting. I suspect it has something to do with G-protein coupling and the shape/charge of the ethyl group, but that's getting far out of my areas of expertise.

Admittedly, I don't completely understand the methodology, or some of the npKi stuff. But at the very least this should spawn some interesting further research. If this all turns out to be supported the pharmacological understanding of psychedelic action is in for an overhaul.