Published New psychedelic-like drugs could treat depression without making you trip

[placebonaut]

New psychedelic-like drugs could treat depression without making you trip

UC Davis researchers created brand-new psychedelic-like compounds by shining UV light on amino acid-based molecules. These compounds activated key serotonin receptors tied to brain plasticity and mental health benefits, but surprisingly did not cause hallucination-like behavior in animal tests...

www.sciencedaily.com

UC Davis researchers created brand-new psychedelic-like compounds by shining UV light on amino acid-based molecules. These compounds activated key serotonin receptors tied to brain plasticity and mental health benefits, but surprisingly did not cause hallucination-like behavior in animal tests. Scientists say the discovery could lead to future treatments for depression, PTSD, and addiction without the intense psychedelic experience.

Interesting though I do wonder how much the positive benefits of the trip are related to the psychedelic effects?

https://pubs.acs.org/doi/10.1021/jacs.5c19817

 

[foodcrisis]

didn't read this, but i got an article in my browser feed a few months back about a similar or the same drug and it treats schizophrenia. i googled to refresh my memory:

"Researchers have developed a non-hallucinogenic analogue of LSD called JRT. By swapping the positions of just two atoms in LSD, scientists created a molecule that promotes brain cell growth and synaptic connectivity without the psychedelic trip. It is being studied for its potential to treat schizophrenia and severe depression."

 

[Didgital]

Actually, I read the article and I'm not 100% but I believe it is referencing this paper.

https://pubs.acs.org/doi/abs/10.1021/jacs.5c19817

It's actually super cool paper. They combine tryptamines, amino acids, and UV light to create entirely new ring-constrained tryptamine analogs with azocinoindole cores... News to me.
Sad they aren't actually psychedelic.

 

[placebonaut]

Actually, I read the article and I'm not 100% but I believe it is referencing this paper.

https://pubs.acs.org/doi/abs/10.1021/jacs.5c19817

yeah think it's that paper but I can't get access to it to read it

Sad they aren't actually psychedelic.

if it opens up a new option to treat depression then it's still good news

 

[Didgital]

What are you talking about? Just scroll down the page in the link I sent it has full text.

 

[placebonaut]

hmm, maybe all the extensions I use to block shit but I get this when I try to read it

Read this​

To access this article, please review the available access options below.

Recommended

Access through Your Institution​

You may have access to this article through your institution.


Access Through Your Institution

EDIT: I'm dumb, it's lower down

https://pubs.acs.org/doi/suppl/10.1021/jacs.5c19817/suppl_file/ja5c19817_si_001.pdf

 

[Didgital]

What are you talking about? Just scroll down the page in the link I sent it has full text.

Well, the actual publication no, but all the experimental and supporting info available as a PDF or as I said in that link.

 

[Didgital]

keep going down.

 

[Didgital]

hmm, maybe all the extensions I use to block shit but I get this when I try to read it




EDIT: I'm dumb, it's lower down

https://pubs.acs.org/doi/suppl/10.1021/jacs.5c19817/suppl_file/ja5c19817_si_001.pdf

A lot of the times, the "meat" of the paper is only found in supporting info anyway. Theres 52 pages of syntheses and hundreds of pages of spectral data. its quite a beefy paper actually.

 

[placebonaut]

yeah 300 pages of stuff that's way above my ability to understand.

seems a pretty extensive paper.

hopefully some credible stuff in here that will be useful

 

[Allylbenzene]

Researchers have developed a non-hallucinogenic analogue of LSD called JRT. By swapping the positions of just two atoms in LSD

This is essentially LSD made using isotryptamine instead of tryptamine. Akin to DMT and isoDMT.

 

[neversickanymore]

please use this thread to post and discuss published studies that were not posted in DS.

⫸STICKY⫷ Thread 'Drug Studies General Discussion (suggest, & discuss studies here, or chat socially!)'

Jul 21, 2013

Drug Studies General Discussion (suggest, & discuss studies here, or chat socially!)

Drug Studies General Discussion

Please use this thread for general discussion that doesn't belong in one of the specific study threads.

Some examples of things that fit in this thread: discussion of studies not posted on Bluelight, discussion of what the results of studies mean and what we can learn from them, suggesting ideas for new studies, or requesting study results that you've been unable to find using traditional methods (i.e. Google).​

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