fishoutofwater
Greenlighter
- Joined
- Jun 11, 2014
- Messages
- 23
*Sorry this is so long...PLEASE READ AND REPLY*
Past experience with Opioids/drugs:
I took my first opioids back in June 2010 after a surgery. I noticed when taking them for pain the euphoria experienced. Having never even (to this day) drank or smoked weed (I know, holy shit), I'm definitely a little naive to drug culture. That said, I've always been interested in pharmacology, etc. I have spent the past week reading threads all over this site about opioid use, particularly: safe use, potentiation, and tolerance. I can probably count on both hands the amount of times I've got high on either Hydro or Oxy (maybe a few more
), but seem to have developed a decent tolerance that has come back fast.
Concerning my tolerance, I remember last time around, which was about a year or so ago, I got high off of 25 - 35 mg just fine (couldn't say whether it was Hydro or Oxy; I know Oxy is more potent). This time around, granted I started dosing 10mg Oxy 2 - 3 times a day to manage pain just over a week ago, I started with around 30mg Oxy (percocet) and got a good high that lasted around 3 - 4 hours. Then I went to 40mg I believe the next day and got a similar, perhaps less euphoric high. Then a third day in a row (Sat. night) I took around 50mg w/800mg cimetidine 1 hour prior & 1 Benadryl at the same time (I remember in a 24 hour period I was over 4,000 mg acetaminophen, which I know put me at risk for liver damage), but this time the high was surprisingly less potent. To be sure, during these 3 days I wasn't taking any Oxy in between doses and got a refill of just Oxy with no acetaminophen just before the last dose.
Anyway, needless to say I was really surprised and bothered that it seemed my tolerance has raised so quickly when I really haven't used much at all my whole life. So I started reading everything I could find on here about tolerance, as well as potentiation. And though I came across a lot of interesting stuff, I was confused and disappointed with the difference of opinion I found. I've read everything from people using 1 - 2 times a week for years, never needing to up their dose (from like 20mg!), to people who didn't use for a year and their tolerance comes back within a few highs to 100mg+ (I realize a huge factor here is the frequency of using). There were a few clear things learned, like how opioid tolerance increases quickly with consistent use, but mostly my reading led to more and more confusion and disappointment. So anyway, with all this in mind, I would appreciate some knowledgeable and experienced feedback on these issues (i.e., tolerance/potentiation relative to my information). Specifically, how I can effectually use the last 220mg of Oxycodone (I doubt I can get another refill and don't have access to opioids otherwise). I am now about 4 days of zero opioid use. (Last use was Saturday night, if I remember correctly...)
Current Medications (I've read about the interactions, but they are very vague):
Morning/Day: 60mg Duloxetine (i.e., Cymbalta), 150mg bupropion XL (i.e., Wellbutrin XL), 1800mg gabapentin (i.e., Neurontin)
*I've actually read from several sources that taking Neurontin before Morphine and Hydrocodone decreases the absorption by about 22%! I don't know how this applies to other opiates, but it must be somewhat similar. (Conversely, taking Neurontin after said opioids increased absorption of gapapentin by 44%.)
At Night: 10mg Diazepam (i.e., Valium), 0.5mg Triazolam (i.e., Halcion)
*I've experimented with different SSRIs and Atypical Anti-Depressants and taken the benzos for almost a year now. I bring this up because I wonder if my benzodiazepine tolerance has effected my opioid tolerance at all since I've taken these benzos everyday for almost a year.
Height: 6'0" Weight: 180lbs
I apologize for the long post. I just wanted to share all the info necessary to get the right answers. Also, I realize there is no "perfect" answer because these things differ from person to person. Your help is appreciated.
Past experience with Opioids/drugs:
I took my first opioids back in June 2010 after a surgery. I noticed when taking them for pain the euphoria experienced. Having never even (to this day) drank or smoked weed (I know, holy shit), I'm definitely a little naive to drug culture. That said, I've always been interested in pharmacology, etc. I have spent the past week reading threads all over this site about opioid use, particularly: safe use, potentiation, and tolerance. I can probably count on both hands the amount of times I've got high on either Hydro or Oxy (maybe a few more

Concerning my tolerance, I remember last time around, which was about a year or so ago, I got high off of 25 - 35 mg just fine (couldn't say whether it was Hydro or Oxy; I know Oxy is more potent). This time around, granted I started dosing 10mg Oxy 2 - 3 times a day to manage pain just over a week ago, I started with around 30mg Oxy (percocet) and got a good high that lasted around 3 - 4 hours. Then I went to 40mg I believe the next day and got a similar, perhaps less euphoric high. Then a third day in a row (Sat. night) I took around 50mg w/800mg cimetidine 1 hour prior & 1 Benadryl at the same time (I remember in a 24 hour period I was over 4,000 mg acetaminophen, which I know put me at risk for liver damage), but this time the high was surprisingly less potent. To be sure, during these 3 days I wasn't taking any Oxy in between doses and got a refill of just Oxy with no acetaminophen just before the last dose.
Anyway, needless to say I was really surprised and bothered that it seemed my tolerance has raised so quickly when I really haven't used much at all my whole life. So I started reading everything I could find on here about tolerance, as well as potentiation. And though I came across a lot of interesting stuff, I was confused and disappointed with the difference of opinion I found. I've read everything from people using 1 - 2 times a week for years, never needing to up their dose (from like 20mg!), to people who didn't use for a year and their tolerance comes back within a few highs to 100mg+ (I realize a huge factor here is the frequency of using). There were a few clear things learned, like how opioid tolerance increases quickly with consistent use, but mostly my reading led to more and more confusion and disappointment. So anyway, with all this in mind, I would appreciate some knowledgeable and experienced feedback on these issues (i.e., tolerance/potentiation relative to my information). Specifically, how I can effectually use the last 220mg of Oxycodone (I doubt I can get another refill and don't have access to opioids otherwise). I am now about 4 days of zero opioid use. (Last use was Saturday night, if I remember correctly...)
Current Medications (I've read about the interactions, but they are very vague):
Morning/Day: 60mg Duloxetine (i.e., Cymbalta), 150mg bupropion XL (i.e., Wellbutrin XL), 1800mg gabapentin (i.e., Neurontin)
*I've actually read from several sources that taking Neurontin before Morphine and Hydrocodone decreases the absorption by about 22%! I don't know how this applies to other opiates, but it must be somewhat similar. (Conversely, taking Neurontin after said opioids increased absorption of gapapentin by 44%.)
At Night: 10mg Diazepam (i.e., Valium), 0.5mg Triazolam (i.e., Halcion)
*I've experimented with different SSRIs and Atypical Anti-Depressants and taken the benzos for almost a year now. I bring this up because I wonder if my benzodiazepine tolerance has effected my opioid tolerance at all since I've taken these benzos everyday for almost a year.
Height: 6'0" Weight: 180lbs
I apologize for the long post. I just wanted to share all the info necessary to get the right answers. Also, I realize there is no "perfect" answer because these things differ from person to person. Your help is appreciated.