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New Drug Technology with Opiate Application ; )

  • Thread starter Thread starter Wrap&Roll
  • Start date Start date
W

Wrap&Roll

Guest
Hey all, (Phreex I think you might find this particularly interesting)
I do part time research for in biotech sector and I recently was refered to a company that just patented a brand new opiate drug delivery system. The company can create 'Drug Affinity Complexes or DAC's which are constructs containing a drug, a linker molecule and a reactive end that binds to targeted proteins in vivo.'
What this means is that drugs can remain active for days or weeks rather than hours, while side effect are greatly reduced.
They have had the most positive response from, no surprise here, opiod compounds. The company has proved that it can SAFETLY prolong the duration of action to a half-life measured in weeks.
What does this mean for us?? The possiblity of opiate anti-depressants, or constant receptor stimulation, I don't know. But I think its a step in the right direction. It would be quite nice if a binge of three injections lasted three weeks ; )
 
that would be really phat, no depression because of opiads, and feeling good all day long, for weeks... but i still don't understand how this system of delivery deals with a persons tollerance to a med. do you know what i mean? if a person takes an opiate for a long period of time, eventually it won't do shit for them anymore.... they'll need more and more.
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all of you who are: blazin, smokin, tokin, rollin, snortin, raillin, bumpin, poundin, popping, droppin, bangin, pluggin, rippin, wippin... need to stop trippin! i'm ONLY "FUCKIN" around.
 
Tolerance is an issue. If the apply this technology toextremely powerful synthetic opiates then the can simply have incresing strengths. This would be convenient because you would only be taking one pill a week. Some of the synths are so powerful they are measured in such small quantites that it could potentially go on for quite a while before they become ineffective.
 
This is the caliber of posts I've been lusting for...I think I'm getting a hard-on ; )
Wrap&Roll can you get more information on this, or provide links to papers or writeups on the subject? Or is everything still under wraps...
Thanks,
Pure
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What is freedom? I don't know anymore. Its something so far removed from anything I've ever experienced that I'm not sure I can even comprehend it. Make Freedom A Reality
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I think the problem with super long-acting drugs and infrequent administrations is that, for many people, the physical act of preparing and TAKING a drug is such a huge part of the thrill and addiction, especially for IV users, that even a constant steady high would feel cheap if you weren't administering something at least once a day.
As for treating depression with this class of drug, I'm all for it.
 
the key to real long term opiate therapy over days at a time, is not to deliver something that will act for a longer time, because the body says hey this fucker is staying past its welcome lets gang up on it, and boom it doesnt help anymore, what you need is repeated administraion which also in turn provides a peak each time its administered which diminishes extreem pain when its needed. This will keep the body from building such a tollerance that it wont work anymore, because its not seeing all this drug ready to act at once, its just seeing one dose, so it wont be prepared the next time you administer another dose, and it will be more effective. had you used a sustained release, your body would be already tollerant to it from having the whole amount present the whole time, it knows whats there and is ready to counter it, and thus your relief is diminished.
With a sustained release, which cant up the dose instantly when you hurt more, you just have to accept the pain.
Sustained release is the governments answer to abuse of pain killers, and its supposedly more effective, but it isnt, its a cop out from real therapy just because its viewed as evil, and most of these sustained release pills are formulated on the basis that they wont be usable by an addict, and golly gee it just so happens that this also diminishes the relief possible.
What is needed is an instant access route, like a picc line or a permanent IV catheter, and a delivery system on their person like a morphine pump that will deliver a dose to the person when needed and holds enough to take care of their needs for multiple days at a time, we already have this around its just not used and hard to implicate into a lot of people, and mostly for moral reasons.
There is a likened device for diabetics that holds insulin and has a constant line into the body so that there are no needle sticks and it can deliver it instantly, even in the middle of a presentation at work for instance. I knew someone who had one on them back in school and i thought it was a pager at the time like everyone else, but i learned about it and i thought it was the most innovative thing ever.
IV is the route to go for pain relief, because it needs to be instant and strong enough to kill the pain right then, and it also needs to be efficient and not waste drug like oral does, and iv is perfect for this application.
The only problem is, IV is seen as the way that "junkies" use opiates, and then people who eat them orally, thats ok because they arent IVing it so they arent getting high, well news flash its the same drug your just denying a person in need the speed of onset and the intensity of relief neccesary just for moral or opinionated reasons, and this IS NOT WHAT MEDICAL SOCIETY SHOULD BE ALLOWED TO DO.
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I have a good idea, instead of using serotonin reuptake inhibitors, why dont we use opiate reuptake inhibitors that keep the small amount of endorphins (bodys natural opiates) present, able to bind to the receptors, i bet this would keep an addict from relapsing or a person from being really depressed a lot more than any other current drug, i wonder why there arent opiate reuptake inhibitors because i know they would be seriously more helpfull than serotonin uptake inhibitors because most peoples depression isnt because of serotonin, its because of endorphins. Just a thought that i think is ground breaking
smile.gif

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~The Recreational Pharmacist
AIM: TheTripDoctor
[This message has been edited by TheTripDoctor (edited 03 August 2001).]
 
They have had the most positive response from, no surprise here, opiod compounds. The company has proved that it can SAFETLY prolong the duration of action to a half-life measured in weeks.
Click to expand...
Hah.. how many "safe" drugs end up being proven "unsafe" if not outright dangerous within a few years?
Your average person suffering from some form of chronic pain that isn't hooked on their medication does NOT want to be feeling the effects for longer than neccessary. For someone that is sensitive to certain opiods and gets lots of side effects, well, I don't understand how you'd be able to find out ahead of time until it's too late. "Reduced" side effects does not mean "no" side effects. Not to mention most people have lives and things to do and not everyone wants to be high all the time.
This sounds completely impractical for general purposes. It would make sense for someone who's bed ridden or taking 80mgs of Oxy a day or something really severe. And it sounds great for junkies. Hell, I'd use something like that. But I can't see where this is going to be a common technique to fight pain. I can see it getting the hell abused out of it. And I can see a lot of people ODing from it from the abuse.
This sounds only a few steps up from Purdue claiming they're spending millions to research new opiod compounds that will relieve your pain but not get you high.
As for some kind of opiate anti-depressant.. uh.. your dopamine receptors become less sensitive everytime they're over stimulated as they are with duh, opiates. I'm sure somewhere in there playing with them constantly in some way shape or form for long periods of time would probably result in some negative consequence.
 
i have somthign to ask lets say u did this and u were fucked up for a week spendign a week crazy fucked up i cant imagine going back down to be sober it would be so depressing
 
Hey, if possible, could you e-mail me some more information, Wrap? My mother has a disease that causes her to require high end pain medication (Trip was talking about a morphine pump -- she has one installed (on the opposite side as her spinal cord stimulator)) and I'd be interested in reading something about this.
And Trip's right -- for breakthrough pain, time-released anything *sucks dick*. She uses fentanyl suckers.
smile.gif
 
I would love to e-mail you with more information but you don't have your address listed. Just e-mail me. Hope your mom is doing better.
 
wrap, email me too please
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What is freedom? I don't know anymore. Its something so far removed from anything I've ever experienced that I'm not sure I can even comprehend it. Make Freedom A Reality
http://www2.bluelight.ru/ubb/Forum31/HTML/000557.html?reload=0
 
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