Miscellaneous New development in serotonergic compounds

[Leprechaun]

Well, this is more chemistry than pharmacology. But a new way to create serotonergic drugs from amino acids using UV light has been developed…

Creating Hallucination-free, Psychedelic-like Molecules by Shining Light on Life’s Basic Building Blocks

UC Davis researchers have developed a new method that uses light to transform amino acids — the building blocks of proteins — into molecules that are similar in structure to psychedelics and mimic their interaction with the brain. Like psychedelics, these molecules activate the brain’s serotonin...

www.ucdavis.edu

 

[Leprechaun]

Somewhat dubious they refer to these compounds as non psychedelic psychedelics.

It’s like saying it’s water without the h2o…

 

[iom]

Psychedelic is a buzz-word now I guess. It looks good in a press release. The new compounds appear (in animals) to be non-psychedelic 5-HT2A agonists. That's about all that's known about them so far. I guess the researchers hope they may offer some of the clinical benefits that psychedelics do, without the trip, but that is not yet established.

 

[somnusmorsdegrees]

you should be skeptical, of animal models. That
head twitch is not a completely empirical response, and the simulations may account for their location, yet substances share a variety of known effects, and everyone is different. I care to mention also, UV light is the instrument mentioned in the article, empirical protocols demonstrate, however, classical psychedelics show a sensitivity to sources of light, and follows the breakdown of substance.

and belated birthday to A. Hofmann.

 

[somnusmorsdegrees]

honestly very proud the work of pharmacuetical companies and UC Berklee alongside UC Davis developing new compounds and psychedelic drugs. who else?! it may seem controversial, but this is great.