Stimulants Neurotoxicity

[Speedaddict69]

What does amphetamine neurotoxicity mean exactly and how dangerous is speed as a neurotoxin?

 

[tricomb]

Please checkout the existing mega thread on this..

http://www.bluelight.ru/vb/threads/...oxicity-and-Tolerance-Reduction-Prevention-II

 

[bronson]

As for what it is exactly.

Neurotoxicity occurs when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system in such a way as to cause damage to nervous tissue. This can eventually disrupt or even kill neurons, key cells that transmit and process signals in the brain and other parts of the nervous system. Neurotoxicity can result from exposure to substances used in chemotherapy, radiation treatment, drug therapies, certain drug abuse, and organ transplants, as well as exposure to heavy metals, certain foods and food additives, pesticides, industrial and/or cleaning solvents, cosmetics, and some naturally occurring substances. (Source)

I also thought this post @ reducing amphetamine neurotoxicity by Riemann Zeta was very concise and full of good info.

There are a number of good strategies for preventing amphetaminergic neurotoxicity:

(1) Use regular d-amphetamine, instead of the more neurotoxic methamphetamine and MDA/MDMA (anything with a methylenedioxy substituent is going to produce more oxidative stress).
(2) Keep your dosage reasonable--don't use massive tweak-a-thon binge doses. Also, always take your amphetamines orally as they were meant to be taken, that way you get a nice, smooth stimulation without a sudden massive jump in plasma concentration.
(3) Ensure that your core body temperature stays as low as possible--neurotoxicity is directly linked to hyperthermia, so chill out (literally). You can use a little paracetamol (a little) with a NSAID to lower a fever if it occurs.
(4) For anti-oxidant supplements, try Vitamins C, D and E, as well as resveratrol. Levo-deprenyl is also good, but keep your dose low if you are taking it with amphetamine. Ergoloids like hydergine work too.
(5) Throw in a little magnesium to lower amphetamine tolerance.

Hope that helps some too.