This seems very uncommon with 4-aco-DMT. It's usual side effects include anxiety, nausea, and possible feelings of unwanted stimulation after the trip is done. Note that those side effects will not be present in everyone, all the time. It is considered, along with 4-ho-DMT (Psilocin) to be one of the most physically transparent psychedelics known to man.
25i-nbome is a different case. Some people consider it very smooth, others have side effects like vasoconstriction, overstimulation, nausea, diahrhea, etc. It also does not have the track record of 4-aco-DMT, which has been available since 2006.
Anything that causes vasoconstriction and especially blue hands is something you should not continue to take, however.
Have you tried lower doses of 4-aco-DMT and noticed the same effects? 40mg is a high dose. Most I ever took was 35mg and I've taken 4-aco-DMT quite a number of times. But even at 35mg I did not feel the side effects were more produced than at doses in the teens of milligrams. But I would be very suprised if you took 10mg of 4-aco-DMT and noticed any side effects at all.
Not all psychedelics are "easy on the body and harmless" by any means. Bromo-dragonfly is a notorious example. DOB is another example. Even DOM can be quite the white-knucle ride. 2C-T-7 is another example which is physically risky especially at higher doses. There are a good number of psychedelics that are known to have pronoucned physical side effects for most people. 25i-nbome is borderline one of these. 4-aco-DMT however is known to be on the lesser end of the spectrum when it comes to these unwanted effects. For most people it is basically a cleaner version of mushrooms.
However, I have fainted (passed out) from mushrooms on at least two or three occasions. It is not known why this can happen, but it can. Vasoconstriction and blue hands, on the other hand, is not to be expected at all.