The double concave ones that are round are impossible to fool with, either chemically, thermally, or mechanically. I destroyed a brand new coffee bean grinder trying, and used every solvent that would be readily available to Joe Average, no luck. The old TIMER-X ones with 8 (6?) sides can be defeated with IPA. As tacodude wrote, from what Ive heard the new generics are the old TIMER-X system. I *suppose* one could half-way bust the new formulation by replicating stomach conditions, i.e. 24 hour soak in slightly acidic warm (100*F) solvent, however I've not tried that method with TRF Opanas. Did try it with OPs, was very disappointed with the results. If you have a fast metabolism, you could very easily poop out an almost completely intact pill.