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Need advice from Ritalin and MDMA users

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sydneyleb

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Jul 12, 2011
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I have not rolled in 6 months and tried last night with tested molly. I am a Ritalin user and it did not cross my mind that it would cause the molly not to work. I dosed a generous amount and within an hour I experienced blurred vision and other MDMA effects without the rolling part. A little research online suggested that the Ritalin was blocking the pathways that the MDMA needed to do its thing. Ok so lesson learned and no big deal. I used a strong indica with a .5 Xanax to put me to sleep when I realized nothing fun was going to happen. I also pre and post loaded with the supplements from the ecstasy users bible allowing me to wake up feeling fine. My question to Ritalin users is am I ok to try to roll tonight? I did not take any Ritalin today. Is that enough time for my body to clear the Ritalin and open up those need pathways for a roll tonight. Thanks.
 
You'll probably want to try again in month and maybe give yourself a week or so off the ritalin, ritalin does release some of the pleasure chemicals that mdma releases (dopamine, norepinephrine). Also, mdma is best used sparingly, once a month at minimum but most suggest 3 months. I'm afraid I'm not as familiar with mdma abuse though, so I'm sure someone else will be able to give a more complete answer. Not saying you've abused it but while I've had experience ritalin as well as mdma, its been a while since I've taken rit and with mdma, I'm just not as familiar with, if any, negative/cancelling side effects besides those I've read about on bluelight.
 
The Ritalin is just a daily prescription. Yesterday I took 20mg of Ritalin in the morning and another 10mg about 3 hours before I preloaded. The molly was taken 1.5 hours after the preload. Ya, Im not an abuser of drugs any longer, Im too old now. Ha ha. I need my brain for studying electrical engineering.
 
MDxx and ritalin are cross tolerant if I remeber right...the more ritalin you take the more you build your MDMA tolerance at the same time.
 
MDxx and Methylphenidate (Ritalin, Concerta etc) are indeed cross-tolerant. I was prescribed 63mg of Concerta to take daily during the week and 30mg Ritalin to take on the weekends. Most of the time I would never take the Ritalin on the weekend anyway, so I guess that doesn't really matter. However, there were some days where I would be taking the Concerta in the daytime and rolling later on in the evening. I never really had a problem with cross-tolerance. I could easily take 100mgs of pure MDMA and feel just awesome, even with having taken a large dosage of methylphenidate about 10-14 hours prior. I'm sure it wouldn't hurt to avoid taking your Ritalin on the day that you plan to roll.
 
I've never used Methylphenidate on a daily basis for an extended period of time, but I have used it daily for a about 10 days during finals and then dropped some MDMA once all my exams were done. I did not notice any cross tolerance. You might want to take a week-long break from ritalin before dropping, if you're confident that it's a good thing to do (at least in the US, doctors give out speed like candy - I am not sure if this is true for Australia as well).

And what do you mean by feeling all the effects of MDMA without rolling? Perhaps you just took too much and didn't have a good experience?
 
in experience ritalin definetly dulls the experience. come off your ritalin and give your brain a break before you try rolling again. also remember that if you are being medicated for add then rolling may not be the best idea.. but hey i'm not your mom :p
 
There's also a chance that you just got sold crappy MDMA. Just putting that out there.
 
Ritalin (methylphenidate) is a dopamine-norepinephrine reuptake inhibitor. It will block the MDMA from going into norepinephrine and dopamine transporters, leaving MDMA to act only on the serotonin transporters. Euphoria requires all three monoamines (serotonin, dopamine, norepinephrine) to be released, and at the proper ratio. A pure serotonin releaser is not euphoric, but often dysphoric, just like PMA.

Adderall is different since it is an amphetamine, which does not compete with MDMA for the transporters. A lot of ecstasy pills have amp/methamp in it even. They go fine together.

I've (tried) to roll after taking 36mg Concerta during the morning. It didn't work, I just got the PNS effects and some energy, but it was very dysphoric and I had to leave the concert before the main act even started. I basically had a panic attack.

Try at your own risk. I'd give at least 2 days of Ritalin abstinence before rolling.
 
ive been taking adderall almost every day for a couple months prior to rolling. i hadnt rolled in 6 months
i dropped a high but not ridiculous amount of mdma. most of my friends rolled bawls
i got eye wiggz, pleasant sweats, and could just tell that i had good quality x in me.
the only thing is, i didnt really feel any different and i think it was because of the adderall.

also if i take my adderall and work out heavily i feel like im rolling, but without the sketchiness.
 
k-opioid said:
Ritalin (methylphenidate) is a dopamine-norepinephrine reuptake inhibitor. It will block the MDMA from going into norepinephrine and dopamine transporters, leaving MDMA to act only on the serotonin transporters. Euphoria requires all three monoamines (serotonin, dopamine, norepinephrine) to be released, and at the proper ratio. A pure serotonin releaser is not euphoric, but often dysphoric, just like PMA.

Adderall is different since it is an amphetamine, which does not compete with MDMA for the transporters. A lot of ecstasy pills have amp/methamp in it even. They go fine together.

I've (tried) to roll after taking 36mg Concerta during the morning. It didn't work, I just got the PNS effects and some energy, but it was very dysphoric and I had to leave the concert before the main act even started. I basically had a panic attack.

Try at your own risk. I'd give at least 2 days of Ritalin abstinence before rolling.
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Methylphenidate is a substituted amphetamine derivative...
 
Despite methyphenidate's structural similarities to amphetamine, its mechanism of action at DAT and NET is fundamentally different than amphetamine-based monoamine releasing agents. Methylphenidate binds to DAT and NET and blocks them, while amphetamine/MDMA is simply a substrate. Like most reuptake inhibitors, it has much stronger binding affinities to the respective monoamine transporters than amphetamine-based releasing agents, which are merely substrates (well that is still debated but that still doesn't change the binding affinities). Amphetamine and/or MDMA will be blocked from entering the axon if methylphenidate is already bound to DAT or NET. In the case of a methylphenidate and MDMA combo, MDMA will only be able to exert significant serotonin release, and not dopamine or norepinephrine, which will significantly alter/dampen the MDMA experience. Cocaine and MDMA combo will be similar, except that cocaine blocks SERT as well--we already know that cocaine and MDMA don't mix well. Also, we all know what serotonin reuptake inhibitors do to the MDMA experience, though obvs SSRIs are much much stronger at dampening MDMA's effects.
 
k-opioid said:
A pure serotonin releaser is not euphoric, but often dysphoric, just like PMA.
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I believe pure 5HT releasers aren't actually dysphoric. Just take a look at the MDAI thread in PD. While pure 5HT releasers lack the magic of MDMA, they seem to be at least mildly pleasant. And PMA is definitely not pure 5HT releaser.
 
k-opioid said:
Despite methyphenidate's structural similarities to amphetamine, its mechanism of action at DAT and NET is fundamentally different than amphetamine-based monoamine releasing agents. Methylphenidate binds to DAT and NET and blocks them, while amphetamine/MDMA is simply a substrate. Like most reuptake inhibitors, it has much stronger binding affinities to the respective monoamine transporters than amphetamine-based releasing agents, which are merely substrates (well that is still debated but that still doesn't change the binding affinities). Amphetamine and/or MDMA will be blocked from entering the axon if methylphenidate is already bound to DAT or NET. In the case of a methylphenidate and MDMA combo, MDMA will only be able to exert significant serotonin release, and not dopamine or norepinephrine, which will significantly alter/dampen the MDMA experience. Cocaine and MDMA combo will be similar, except that cocaine blocks SERT as well--we already know that cocaine and MDMA don't mix well. Also, we all know what serotonin reuptake inhibitors do to the MDMA experience, though obvs SSRIs are much much stronger at dampening MDMA's effects.
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Wtf are you talking about? Based on what you are saying here, amphetamines also block out the MDMA, which is simply not the case..

The fact cocaine and MDMA do not mix well has nothing to do with Ritalin or amphetamines.
 
severely etarded said:
Wtf are you talking about? Based on what you are saying here, amphetamines also block out the MDMA, which is simply not the case..

The fact cocaine and MDMA do not mix well has nothing to do with Ritalin or amphetamines.
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Sure it does. Cocaine and Ritalin have the same exact effect on the brain and workt he same way by blocking the reuptake of dopamine'only difference is that Cocaine reaches the BBB quicker. so therefore MDMA does not mix well with ritalin as cocaine and ritalin act in same manner
 
opiatekrzy said:
Sure it does. Cocaine and Ritalin have the same exact effect on the brain and workt he same way by blocking the reuptake of dopamine'only difference is that Cocaine reaches the BBB quicker. so therefore MDMA does not mix well with ritalin as cocaine and ritalin act in same manner
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Interesting, thanks for the info! I never tried ritalin but it sounds pretty shitty anyway.

Why not just use an amp like dexedrine or adderall? Much cleaner effect.
 
so I'm reading a lot of contradicting opinions here....

I've been taking vyvanse/dexedrine for about a month now, took a 5 day break 4 days ago. Also have been taking Ritalin on some days instead to keep my tolerance to both drugs low. My tolerance to Ritalin is very low, I cant take more than 10mg at a time or else i'll feel too high to go to school and not talk my face off.

I plan on rolling tomorrow night, will the roll be affected in any way if I took either vyvanse or Ritalin in the morning/afternoon? I am leaning towards taking the ritalin since it doesn't last as long. Or would I just be better off not taking anything?
 
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