The only unclean psychedelic i've tried is the 25B-NBOMe and I can tell you that it doesnt change you on the short term. It's been 2 years and I still have HPPD, anxiety, insomnia and mental hyperactivity. Alredy had everything but HPPD before the Trip but it got WAY WORST after. For 6 months after the trip, I had Acid like experiance on weed and weed-like experiances sober (on a visual level only) I cant say that wasnt fun but still it came with INTENSE restlessness. Since this first psychedelic experiance, I stuck with tryptamines.
To answer your first question clearly; To me it has every long term side effect LSD doesnt have because LSD doesnt have long term side effects where NBOMes do. And they are ususally anxiety, depression and insomnia.