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Natural Endorphins and opiates/opioids

delphinen

delphinen

Bluelighter
Joined
Mar 20, 2007
Messages
991
Location
Gensokyo
I suppose that a chart would be impossible to make because endorphins are released into the blood stream randomly and they are very different from what we know as opiates/opioids, but since some mammals are in fact capable of producing morphine itself, instead of endorphins which does not bind to the same MU receptors, most importantly, the μ-opioid, I wonder how much endorphins equals some Morphine and how much the body releases it per day; also why cutting (as in selfharming) produces so much analgesia, sedation and respiratory depression.. I think this really worth researching about it. I do wonder too if it is a fact of evolution that we "still make" endorphins instead morphine like other animals.

Thanks in advance.
 
I'd say that a 5 mg shot of pure smack would produce a rush comparable to an orgasm in an opiate naive individual. But I'd say the smack has a much longer half life, so it'd be a difficult comparison.
 
You've three questions:

1) What is the potency of endorphins relative to morphine?

2) On average, how many endorphins are released daily?

3) Why does self-harm produce analgesia, sedation and respiratory depression?

Answers:

1) There are quite a few endorphins; beta-endorphin is 18-33 times more potent then morphine(in before anyone quotes the Wikipedia page saying that it's 80 times ;)).

2) Probably very hard to answer due to all the variable involved, e.g. the food people eat, the exercise they do, how often they engage in sexual activities.

3) Endorphin release is your body's responses to pain; it's no surprised that by binding to the opioid receptors they'd have opioid-like effects.
 
i have found myself feeling on top of the world after a 45minute/ hour run.

When I got on the treadmill first time i went to the gym and did 45minutes of running I came off and felt like I was floating, felt wonderful.
So I guess I must of released alot of endorphins then.

I find the longer you run for the better you end up feeling.
 
has anyone ever drank poppy pod tea on an empty stomach after a 5mile run?

Im thinking of doing this on saturday.

I imagine it would get you alot higher than usual, anyone ever done this before?
 
bighooter: No personal experience, but for what it's worth there were a few users posting in a thread in AusDD a few months ago saying that after a day of physical labor they felt like their opioid of choice got them higher then usual. Almost makes me want to be more active.
 
Fuck beating off when Opiated.

On a side note, I reckon you're gonna enjoy anything better if you've got some endorphins running about from some natural endorphene trigger.

Should encourage me to get off my back and do some excersise.
 
3) Why does self-harm produce analgesia, sedation and respiratory depression?

3) Endorphin release is your body's responses to pain; it's no surprised that by binding to the opioid receptors they'd have opioid-like effects.
Click to expand...

When in extremely depressed and self-loathing moods, I've taken H and cut. Both accentuate the other... It's a strange experience. Problem being, lowered pain threshold means you can go overboard on the cutting :\
 
Mr Blonde said:
bighooter: No personal experience, but for what it's worth there were a few users posting in a thread in AusDD a few months ago saying that after a day of physical labor they felt like their opioid of choice got them higher then usual. Almost makes me want to be more active.
Click to expand...

i find that with tramadol unless you do a lot of physical exercise the high just isn't that high. same with poppy tea. walking for ages brings the buzz to a more lush level.
 
pofacedhoe said:
i find that with tramadol unless you do a lot of physical exercise the high just isn't that high. same with poppy tea. walking for ages brings the buzz to a more lush level.
Click to expand...

I feel the same with some benzos like Clonazepam or even Diazepam.
 
delphinen said:
I feel the same with some benzos like Clonazepam or even Diazepam.
Click to expand...

Gross. Benzos make me lose all my emotions, I don't laugh at movies...I just sit there feeling like nothing. Opiates are waay better after physical activites because you get opiate endorphins plus the endorphins from the workout; amazing high.
 
Mr Blonde said:
bighooter: No personal experience, but for what it's worth there were a few users posting in a thread in AusDD a few months ago saying that after a day of physical labor they felt like their opioid of choice got them higher then usual. Almost makes me want to be more active.
Click to expand...

This is/was actually my preferred way to get high.

The absolute best was doing a little smack, going on a run, taking a shower, then doing more of a recreational dose of smack.

The funny thing about it was the amount before the run was usually equal to the amount used after, except the amount used post-run seemed noticeably more powerful.


I've also noticed that doing a lifting or ab workout while high, would usually send me closer to nod-zone.
 
I agree that after I work-out and then take my prescribed Lortab 10s, they seem to be stronger. I have degenerative disc disease in my neck and carpel tunnell syndrome in both wrists but work-out anyway to keep what I've got from falling apart, lol :)
 
so do you think it would be a good idea to take poppy pod tea before playing 5aside football for an hour?
 
bighooter said:
so do you think it would be a good idea to take poppy pod tea before playing 5aside football for an hour?
Click to expand...

How much nausea do you typically get from pod tea? While I have no doubt it would raise the endorphin levels and the high, I would also be afraid you'd end up puking. (I certainly would).
 
Mr Blonde said:
You've three questions:

1) What is the potency of endorphins relative to morphine?

2) On average, how many endorphins are released daily?

3) Why does self-harm produce analgesia, sedation and respiratory depression?

Answers:

1) There are quite a few endorphins; beta-endorphin is 18-33 times more potent then morphine(in before anyone quotes the Wikipedia page saying that it's 80 times ;)).

2) Probably very hard to answer due to all the variable involved, e.g. the food people eat, the exercise they do, how often they engage in sexual activities.

3) Endorphin release is your body's responses to pain; it's no surprised that by binding to the opioid receptors they'd have opioid-like effects.
Click to expand...

any idea how much Endorphins of the "naturally released" would be the "Beta" ones? and while it would be 18-33 times more potent than M, how much would be "released"? probably nobody has any idea.. :\
 
Morphine is actually produced endogenously by humans, and Beta-endorphin isn't the main ligand for mu-receptors. Endomorphin is, andEnkephalins also bind to mu receptors.
 
ive only ever puked once from poppy pod tea in about 5 times of use.

Im extremely fit, if I wasnt a fitness finatic i'd be a drug addict.

So I guess the answer is yes it would make the high very good.
Because as of yet I cant say the high from poppy pods is that good really... very itchy, very subtle and certainly no euphoria.

and by the way that was off 9pods and on a reasonably empty stomach (hadnt eaten for 3-4hours) considering I eat every 2hours.
 
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