Naphyrone/O-2482

[/navarone/]

Indeed there are carcinogenic concerns regarding this RC as many naphtalenes based molecules are. However TRI properties of the discussed drug are interesting.

IMO the molecule obviously needs a revision, if it was me I would take inspiration from naproxen and attach a methoxy group on the 6th carbon (the southwest one) or either halogenate the 6th and possibly also the 5th carbon.

 

[nevada]

Right, that`s one of many I`m sure. I think there`s something in particular about pronethalol`s structure that allows its napthylene to create an epoxide metabolite.

i've followed all the discussion, made some research and found this abstract:
http://www.sciencedirect.com/scienc...serid=10&md5=7319b36f6daa536f1862d32598655e0f

"Pronethalol is metabolised by two main pathways, side chain oxidation, and ring hydroxylation and conjugation. Five metabolites have been identified by comparison with synthetic substances. Four of these, 2-amino-1-(2-naphthyl)ethanol, 2-naphthylglycollic acid, 2-naphthylglyoxylic acid, and 2-naphthoic acid are formed by degradation of the isopropylaminoethanol side chain. The fifth, the 7-hydroxy-analogue of pronethalol, is partly present in the free form, but the major amount is present as a glucuronide in which the glucuronic acid residue is attached to the phenolic hydroxyl group.
In several species of animals, and in humans, the differences in the major metabolites are of a quantitative rather than a qualitative nature. We have been unable to determine the nature of the proximate carcinogen responsible for producing thymic tumours in mice, but it is unlikely to be one of the major metabolites."

actually, it seems it does not forms epoxides, and the metabolites are unlikely carcinogens. this research is very old, and nobody researched further about this topic, as i can't find other articles about this

 

[Burn it up]

What about naphtalene ring of this molecule? I really don't like it at all.
As many have discussed with JWH-18, these kind of structures could produce epoxides (which are carcinogenic) when metabolized in the body.

A topic I made talking about the carcinogenicity of the naphthalene in JWH-18, which has a lot to do with the one in Naphyrone:

Thoughts on JWH-18 carcinogenicity

 

[InsaneSpeedball]

Have anyone in this thread ever tested it?

I tried it the other day. I do not know how compare it with other stuff for the moment, only tried few small doses. (I get clear headed, and stimulated)

One odd thing with it tough, this one came with total suprise. The PAIN!
It rivals 2-CB when it comes to nose pain, soary troat, u get when insufflating it.

I do not know if this is cause of an unpure batch, or if this molecule is really cruel to your nose.

OOPS, mabye this were posted in the wrong section. MOD, please move it if possible.

 

[InsaneSpeedball]

One more thing.

Do anyone know or have a wild guess if naphyrone would be detected in a drugscreening test.

I have friend who is sentenced to some drugrehab, and have to some test to do every week checking that his not using speed. He just wanted to sample it. Would naphyrone be noticed at all? 8)
Not that it should matter, it is legal. Just wondering.

Or mabye this a stupid idea alltogher. Who knows then he might become naphyrone addict, that might is more toxic than ordinary speed.


OOPS, mabye this were posted in the wrong section. MOD, please move it if possible.

 

[33Hz]

I wonder if anyone in this thread can help me with a question I have?

At what stage in the pharmacological testing of a substance do they begin to look for possible carcinogenic metabolites if it is being looked into as potential medicine for use in humans? Are these things taken into account right from the start before progressing on to the next stage, or can they go overlooked for quite some time? I say this because I was reading about Napthylaminopropane which is currently being looked into as a way of treating certain drug addictions.

There seems to be quite a bit of research done on it, and yet no mention of it being carcinogenic despite it having the infamous and paranoia inducing naphthalene moiety in its structure.

 

[Demonic1]

Naphyrone was synthesized and bioassayed by some guy from hive with nickname demonic. He claims that it is very mild stimulator with main effect was talkativeness. He tried dosage up to 100 milligrams.
Maybe someone have those pdf files?

First of all, let me tell you that all this got me very upset. From the reports read about this "new" so called RC drug I can only conclude that in most cases what is sold as "Naphyrone" is not ß-naphyrone at all. The effects described here and elsewhere on this forum do not match the effects of the true beta-naphyrone which is not even a true stimulant and certainly has no abuse potential as a street drug.
I was the one who gave that name to 1-(naphthalen-2-yl)-2-(pyrrolidin-1-yl)pentan-1-one hydrochloride and published the first report on its simplified synthesis and human psychoactivity (the full report on this and related compounds is still available at Hyperlab). Previous to that there was only the in vitro study published by Meltzer and his group. Their paper and patent, and then my in vivo study, still remain the only veritable information about this compound.

You are all being fooled by some greedy bastard selling some stimulant (probably mephedrone or MDPV) under the false compound name. The idiotic publicity by the media went bellow any quality level. Presenting a drug dealer as an expert on a drug sold from competing drug dealers is as dumb as it can get and a perfect way to spread misinformation and lies. Personally I would like all the RC drug dealers to burn in hell where they belong, but I also think that you consumers should do your duty and do some thinking before letting them fuck you. What is it with you? How can you trust greedy people like that? They are capable of selling you anything and lye about everything. And what do you do? Buy it every time! Instead of checking the scientific literature or veritable sources, you read the speculation from Wikipedia that could as well be a commercial and take it for granted. Consumerism in drug use is stupid.

 

[Ceres]

First of all, let me tell you that all this got me very upset. From the reports read about this "new" so called RC drug I can only conclude that in most cases what is sold as "Naphyrone" is not ß-naphyrone at all. The effects described here and elsewhere on this forum do not match the effects of the true beta-naphyrone which is not even a true stimulant and certainly has no abuse potential as a street drug.
I was the one who gave that name to 1-(naphthalen-2-yl)-2-(pyrrolidin-1-yl)pentan-1-one hydrochloride and published the first report on its simplified synthesis and human psychoactivity (the full report on this and related compounds is still available at Hyperlab). Previous to that there was only the in vitro study published by Meltzer and his group. Their paper and patent, and then my in vivo study, still remain the only veritable information about this compound.

You are all being fooled by some greedy bastard selling some stimulant (probably mephedrone or MDPV) under the false compound name.

The supposed 1-(naphthalen-2-yl)-2-(pyrrolidin-1-yl)pentan-1-one hcl sample I had was definately not MDPV/mephedrone/methylone/butylone. I found it pretty unique in it's subjective effects, aswell as it's physical/chemical properties. It was also (imho) surprisingly free from any significant impurities.

The experiences people are reporting sound nothing like mine either, which was around an hour of mild euphoria, increased sociability and hornyness and then mild dysphoria and unpleasant peripheral side effects that lasted a couple more hours. It wasn't stimulating in the way mdpv is for me atall.

I agree with you about the unrestrained profiteering and reckless consumerism being applied to these drugs, it's bound to end badly. But naphyrone is still a horrible name

 

[hamhurricane]

First of all, let me tell you that all this got me very upset. From the reports read about this "new" so called RC drug I can only conclude that in most cases what is sold as "Naphyrone" is not ß-naphyrone at all. The effects described here and elsewhere on this forum do not match the effects of the true beta-naphyrone which is not even a true stimulant and certainly has no abuse potential as a street drug.

could you elaborate on this please, what are the effects of the real naphyrone like?

 

[dogdice]

nrg-1 (naphyrone)

Whatever this stuff is it's not like mephedrone in my experience. I took some yesterday - probably far too much I realise now, having read the thread.
First of all I found it a hell of a lot easier to snort than mephedrone - which I took to bombing because it was so evil on my nose. Having said that I did have a very slight nose bleed just now.
One definite - and for me rather important - difference is that mephedrone made me feel very horny and yet utterly incapable of an erection. So the girlfriend actually quite liked it - hours of attention for her obviously.
But the naphyrone had the same horny effect, but with a monster erection to go with it.
Like all these drugs, it's easy to keep bumping along - so you forget about sleep, have no appetite for food - all the usual drawbacks.
For me there is the benefit that they put me off drinkng alcohol and smoking tobacco, so I guess that counts as some sort of a plus.
I'd say it has a much bigger kick than whatever they pass off as coke these days, and it is very more-ish. So people are going to end up feeling quite jagged if, like me, they buy more than a gram at a time because it'll all go up the hooter in one session.
I'm not sure how young people cope with the comedowns, whether it's worse for them or not - but I'm 48 years old and they don't bother me at all.
I would say there is a very real danger of people going without sleep for, say, 72 hours, at which point hallucinations set in - visual and auditory - and anyone who has been there knows it's not funny at all. Not something I'd want my kids to go through, that's for sure.
Excellent website. Glad I found it.

 

[tomzorz69]

I've been around for something new to try since a few weeks before the cathinone ban in the UK and the two main ones that I've whittled it down to are Naphyrone and 5-IAI. I always do my research before I try something and this thread has pretty much condemned Naphyrone for me. There seems to be no general consensus on the dangers of this chemical. I feel it's better to err on the side of caution with RCs, although I'll keep watching to see how things develop.

 

[GZero]

Disregard the dangers for a second, you've read the reports, you want that sort of experience?



I know I don't.

 

[MurphyClox]

First of all, let me tell you that all this got me very upset. From the reports read about this "new" so called RC drug I can only conclude that in most cases what is sold as "Naphyrone" is not ß-naphyrone at all. The effects described here and elsewhere on this forum do not match the effects of the true beta-naphyrone which is not even a true stimulant and certainly has no abuse potential as a street drug.
I was the one who gave that name to 1-(naphthalen-2-yl)-2-(pyrrolidin-1-yl)pentan-1-one hydrochloride and published the first report on its simplified synthesis and human psychoactivity (the full report on this and related compounds is still available at Hyperlab). Previous to that there was only the in vitro study published by Meltzer and his group. Their paper and patent, and then my in vivo study, still remain the only veritable information about this compound.

You are all being fooled by some greedy bastard selling some stimulant (probably mephedrone or MDPV) under the false compound name. The idiotic publicity by the media went bellow any quality level. Presenting a drug dealer as an expert on a drug sold from competing drug dealers is as dumb as it can get and a perfect way to spread misinformation and lies. Personally I would like all the RC drug dealers to burn in hell where they belong, but I also think that you consumers should do your duty and do some thinking before letting them fuck you. What is it with you? How can you trust greedy people like that? They are capable of selling you anything and lye about everything. And what do you do? Buy it every time! Instead of checking the scientific literature or veritable sources, you read the speculation from Wikipedia that could as well be a commercial and take it for granted. Consumerism in drug use is stupid.

Can this really be true? If so, then bow down to the famous Demonic! If this is indeed him (and I tend to think so), then this is the first reliable post about this compound at all. I would strongly recommend to read Demonic's post twice and LISTEN TO HIM.
Thanks for your contribution! Much appreciated.

The supposed 1-(naphthalen-2-yl)-2-(pyrrolidin-1-yl)pentan-1-one hcl sample I had was definately not MDPV/mephedrone/methylone/butylone. I found it pretty unique in it's subjective effects, aswell as it's physical/chemical properties. It was also (imho) surprisingly free from any significant impurities.

How did you come to this result? What kind of analysis was run? DC? NMR? MS? Opinions do not count when it comes to purity, but only some kind of real analysis.


I'm highly irritated by the lack of self-reflection and scepticism in many posts of this thread. People tend to believe a lot of shit nowadays...


- Murphy

 

[coombesy]

i have a small sample of this, wouldnt normally buy this but it was free so fuk it but on the baggie it says nrg-1 naphylone and on the site it is labeled as nrg-1 naphyrone, smells like a strong m-cat smell nearly clean white crystaline powder,
just want to check that this is a typo and that there is not another chem going around called naphylone

 

[Ceres]

How did you come to this result? What kind of analysis was run? DC? NMR? MS? Opinions do not count when it comes to purity, but only some kind of real analysis.

Polarised light microscopy and general microchemical analysis in the old lowtech manner; looking at the crystal polymorphism and growth habit produced under various conditions, observation of phase transitions with a hotstage, watching it dissolve in various media, measuring angles of extinction and so on...

I may not know what the hell the substance I was sent actually *is* but I hope I know it intimately enough to characterise it to some useful extent, at least with more confidence than subjective experiential b.s or a colour spot test provides
Is it real analysis... well, I'm not even in school letalone qualified in the field so possibly not.

 

[e n d e r]

No...it's not real analysis.

-ender

 

[windows78]

First of all, let me tell you that all this got me very upset. From the reports read about this "new" so called RC drug I can only conclude that in most cases what is sold as "Naphyrone" is not ß-naphyrone at all. The effects described here and elsewhere on this forum do not match the effects of the true beta-naphyrone which is not even a true stimulant and certainly has no abuse potential as a street drug.
I was the one who gave that name to 1-(naphthalen-2-yl)-2-(pyrrolidin-1-yl)pentan-1-one hydrochloride and published the first report on its simplified synthesis and human psychoactivity (the full report on this and related compounds is still available at Hyperlab). Previous to that there was only the in vitro study published by Meltzer and his group. Their paper and patent, and then my in vivo study, still remain the only veritable information about this compound.

You are all being fooled by some greedy bastard selling some stimulant (probably mephedrone or MDPV) under the false compound name. The idiotic publicity by the media went bellow any quality level. Presenting a drug dealer as an expert on a drug sold from competing drug dealers is as dumb as it can get and a perfect way to spread misinformation and lies. Personally I would like all the RC drug dealers to burn in hell where they belong, but I also think that you consumers should do your duty and do some thinking before letting them fuck you. What is it with you? How can you trust greedy people like that? They are capable of selling you anything and lye about everything. And what do you do? Buy it every time! Instead of checking the scientific literature or veritable sources, you read the speculation from Wikipedia that could as well be a commercial and take it for granted. Consumerism in drug use is stupid.

not all vendors are the same man......few honest folk out there!

but i think the problem is naphyrone is NOT energy-1!! two different things! for me naphyrone is a useful mild-ish chem but energy-1 is a bit to risky......also some folk call both nrg-1 and there's vendors out there that just don't know what they're buying or selling!!

 

[Ceres]

No...it's not real analysis.

-ender

It's realer than the approach a lot of vendors base their claims of 99.x% purity on, in my experience . For sure though, I don't have a formal education in analytical science (yet?) so tend to keep my 'findings' to myself, but PLM and microchemistry themselves are worthwhile 'real analysis', I hope you'll agree.

 

[MurphyClox]

You shouldn't keep these results for yourself, seriously! It would indeed be helpful for lots of drugs users if they were able to identify correctly their drug of choice and to determine the purity.
Providing results of color reactions, thin-layer chromatography (Rf-values, suitable solvent systems, staining reagents), authentic melting points etc., which are all easily reproducible, can actively support harm reduction. It seems to occur occasionally that vendors sell the wrong products, products laced with cutting agents or simply grossly impure stuff.

Take care!

- Murphy

 

[purpleohm]

I can tell you one thing about this drug, its wicked for playing guitar, I play like Hendrix for about 12 hours but then the next day the recordings still sound great but the strings are totally corroded
I've asked a guitar specialist about this and he's never heard of it but suspects that my sweat is acid.... scary shit man!!!

What I used is "energy-1" from a vendor no longer trading