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Naphyrone/O-2482

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TheAzo

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1-(2-naphthyl)-2-(1-pyrrolidinyl)-1-pentanone

http://en.wikipedia.org/wiki/O-2482

Anyone have any information on this stuff? An RC vendor just added this stuff to their product list, continuing the trend of weirdass drugs hitting the RC market with nearly no pre-research.
 
Naphyrone was synthesized and bioassayed by some guy from hive with nickname demonic. He claims that it is very mild stimulator with main effect was talkativeness. He tried dosage up to 100 milligrams.
Maybe someone have those pdf files?
 
You can read another thread here: http://www.bluelight.ru/vb/showthread.php?t=492720

I quote myself: "What about naphtalene ring of this molecule? I really don't like it at all.
As many have discussed with JWH-18, these kind of structures could produce epoxides (which are carcinogenic) when metabolized in the body.


This is something that maybe we should take in account. "
 
If it's just a shitty stimulant, it seems strange that the supplier would have bothered to prepare it, when they sell a few solid stimulants already.

Especially since it's got that napthyl moiety which is uber-un-sexy immediately brings up carcinogenicity concerns.... See: http://en.wikipedia.org/wiki/Pronethalol which looks very similar at that end of the molecule, especially when you consider that beta-ketones are often metabolized to the alcohol...
 
It seems very similiar to MDPV, which in my book is a very potent stim with addictive qualities. Feels very "dirty" compared to other stims plus a very limited potential as an empatogen or euphoriant.

Seems the retailers are pushing this out very aggressively to mephedrone/unexperienced RC users at the moment, with consequences to follow.

One retailer gives this description:

"Energy-1 or Rave is a very powerful plant stimulant. At very low doses it has a fast acting and very long lasting effect. This product is not for human consumption.

A Warning about the risks of human consumption! This is a direct quote from an abuser. Please beware! Research Chemical Only!

"Bought 1g energy 1 last week.....been there done all the drugs from back in the early 90s.....but cannot believe you can buy this stuff, i took third of a gramm friday....didnt sleep till tuesday morning......was good .....what is in that stuff?"
"



--------------


I can't believe how irresponsible people are with RC's these days..

The retailers are basicly saying to their 'loyal' mephedrone crowd:
"Here's a new, commercially branded stimulant drug with no real previous history of human consumption, nor no research at ALL. But it makes you feel good - try it!"

Above "warning quote" is even worse! Some druggie apparently thought "Hey, new drug - i'll just try it and do a huge dose to see how it works"
The few reports I have seen regarding this drug, mention doses from 10-50mg.

He apparently went ahead and did 1/3 gram or ~333mg.. jeez

He might have "done all the drugs from back in the early 90s", but he surely is pushing for a catastrophe to happen with this behavior!! :X
His grammar is a nice addition to his ignorance..
this "sentence": "i took third of a gramm friday....didnt sleep till tuesday morning......was good .....what is in that stuff?"
" pretty much shows how much he cares. Staying up for 4 days - was good. Sure, buddy.
--


I personally think this stuff/business idea is way worse than mephedrone..

First of all, noone really knows if it is Naphyrone in NRG1/Energy-1 or whatever they call it - some dealers even refuse to tell people. So no guarantees for content or purity. Insane.

Second, this stuff is as-good-as blank on research, which definitely activates my spidersense.. Wouldn't touch this with a stick.


Maybe it's time to follow the labelling for once? Not for human consumption.
 
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^^ Nice post - I dont know much about pharmacology but maybe this is the RC makers/vendors quickly thrown together product to get round the impending cathinone ban.
 
this is all so absurd, admittedly i know nothing about contracting synths etc. but why do they keep creating these chems which seem toxic after even a cursory glance when they could be making a beautiful spectrum of methylphenidate analogs which would be outstandingly potent and much safer. 3-Fl-MPH, 3,4-Fl-MPH, ethylphenidate, propylphenidate etc etc etc
 
May I guess - those pyrrolydinil beta-ketones are easier and cheaper to make!
 
Ironically i have found this link and it says of methylphenidate analogues: The most notable compounds are the erythro-(2-naphthyl) analogues which display high binding affinity and selectivity for the serotonin transporter.
0
 
TheAzo said:
If it's just a shitty stimulant, it seems strange that the supplier would have bothered to prepare it, when they sell a few solid stimulants already.

Especially since it's got that napthyl moiety which is uber-un-sexy immediately brings up carcinogenicity concerns.... See: http://en.wikipedia.org/wiki/Pronethalol which looks very similar at that end of the molecule, especially when you consider that beta-ketones are often metabolized to the alcohol...
Click to expand...

Very good point!!!
I can't believe that such shit is hitting the market. It's so damn sad.

- Murphy
 
hamhurricane said:
they could be making a beautiful spectrum of methylphenidate analogs which would be outstandingly potent and much safer. 3-Fl-MPH, 3,4-Fl-MPH, ethylphenidate, propylphenidate etc etc etc
Click to expand...

Ah, but how effective are ethylphenidate & friends on plants??? AFOAF of AFOAF of AFOAF has a ficus that has grown a good 10 meters over the past month because of naphyrone. I will gladly supply photos.

Energy-1 or Rave is a very powerful plant stimulant.
Click to expand...

Is the stimulatory effect limited to very powerful plants, or can shrubbery benefit from it as well?
 
does anyone want to make some educated guesses as to what the metabolites of naphyrone might be? the benzene ring is the major point of hepatic metabolism in naphyrone's brethren. in aPPP the benzene is left untouched and the pyrrolidine ring is oxidized to a lactam. in MPHP the only alpha-propylated pyrrolidinophenone whose metabolism has been formally studied, the alpha chain is hydroxylated. the lack of dihydroxy metabolites could be an advantage over MDPV, maybe its less toxic, or maybe its much worse. naphyrone certainly seems to have caused a disproportionate number of negative and quasi-psychotic reactions for a drug which has been out for such a short time.

but the same question always remains, are the drugs getting worse or the users?

EDIT: i remembered prolintane and pyrovalerone also have alpha-propyl groups, i will have to look into their metabolism
 
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seep said:
Ah, but how effective are ethylphenidate & friends on plants??? AFOAF of AFOAF of AFOAF has a ficus that has grown a good 10 meters over the past month because of naphyrone. I will gladly supply photos.



Is the stimulatory effect limited to very powerful plants, or can shrubbery benefit from it as well?
Click to expand...

haha=D
 
This one also reportedly acts as a serotonin & dopamine reuptake inhibitor, as opposed to a DA/NERI like MDPV or most cathinones. I'd still be more than a bit leery of trying this one though.... I also would not be terribly surprised if O-2482's recent release was indeed a way to head a likely cathinone ban off at the pass, so to speak.
 
Yet more substance to prove my little rant a few months back that people resented.

Enjoy your RCs, guise! After all, what is better than a mindless consumer who succumbs to all marketing ploys? The same one on drugs!
 
^chemicals are chemicals. People do things with them that are either good or bad.

Looked around the net a bit, wapedia & wikipedia had pretty much the same (sparse) info on this substance. They both reported it as a stimulant/empathogen. Is there any truth to this or is it a vendor trying to hype? Obviously it seems as if it would have stimulant properties, I just dunno about the empathogen aspect. Any established dosage info yet? Judging from the amount of tradekey/alibaba type results I got in google it has been around for at least a little while, but i've never read about anyone taking any.
 
I wish that one of the patent holders would sue the fuck out of the research chemical vendors.
naphthyrone is patented worldwide, US2008234498 and similar and the fair use clause does not allow for sale in the way it has been sold.

PMID: 16480278
J Med Chem. 2006 Feb 23;49(4):1420-32.
1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors.

Meltzer PC, Butler D, Deschamps JR, Madras BK.

Organix Inc., 240 Salem Street, Woburn, Massachusetts 01801, USA. [email protected]

Dopamine, serotonin, and norepinephrine are essential for neurotransmission in the mammalian system. These three neurotransmitters have been the focus of considerable research because the modulation of their production and their interaction at monoamine receptors has profound effects upon a multitude of pharmacological outcomes. Our interest has focused on neurotransmitter reuptake mechanisms in a search for medications for cocaine abuse. Herein we describe the synthesis and biological evaluation of an array of 2-aminopentanophenones. This array has yielded selective inhibitors of the dopamine and norepinephrine transporters with little effect upon serotonin trafficking. A subset of compounds had no significant affinity at 5HT1A, 5HT1B, 5HT1C, D1, D2, or D3 receptors. The lead compound, racemic 1-(4-methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one 4a, was resolved into its enantiomers and the S isomer was found to be the most biologically active enantiomer. Among the most potent of these DAT/NET selective compounds are the 1-(3,4-dichlorophenyl)- (4u) and the 1-naphthyl- (4t) 2-pyrrolidin-1-yl-pentan-1-one analogues.
 
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Pure stuff now available through one of the more well known reputable vendors, interested in experiences of this as opposed to NRG-1 which apparently is diluted with god knows what with a ratio of 5:1 to 10:1...
 
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