Naltrexone override for boyfriend quitting oxycodone

[loves2lisa]

Hi everyone. I'm new to the forum. I'm actually here trying to help my boyfriend. He's struggling with a serious Oxy addiction. He was taking between 600-700 mg a day. He went through detox then got a naltrexone implant for 2 months. Now he is on the oral naltrexone. I give it to him everyday. I make sure he swallows it so I know he is definitely taking it. However recently I've seen texts in his phone that are definitely drug related referring to how many pills he wants etc. So my question is can he override the naltrexone pill? And if he can, how much oxy would it take to override it? Anyone know???? Thanks for any help you can give me.

 

[burntserkits]

I'm not sure how to answer this but I used the same drug for rapid detox and could not imagine trying to use while on it *shivers* YUCK! He could be purging it after he's taking it I wish you guys the best though...it's a rough road!

 

[amapola]

Hey loves2lisa,

I'm going to move this over to Other Drugs for you where you can get an answer on the technical aspect of how many opioids it takes to break through Naltrexone's blockade. Questions about the relationship part would be better handled in SLR or TDS so once you get an answer to the initial question feel free to request it get moved onwards.

Homeless >>> OD

 

[Dankycodone]

You can't overide natrexalone with oxycodone. I have an Implant that should last one year, I think maybe subutex/suboxone can overide it but it's not worth the rist since the doctor warned me of serious interaction with all Opiate's/Opioid's. Try talking to him that is the best way you can find out

 

[morphonorconic]

Yeah, all research/anecdotal evidence suggests there's is absolutely no getting high from Opioids while on a Naltrexone regimen.

Could be something other than Opiates he's texting about... Benzodiazepines maybe?

 

[suessmayr]

It doesn't have to be something else - some people go to extraordinary lengths to get around their implants. I've heard from people at NA who cut theirs out, and from people at AA who were so determined to drink that they drank despite being on - I forget what it's called - and were just spewing up bile and blood after literally every sip.

 

[comatoserct]

Yeah, my suggestion is that he puts the pill in his mouth in front of you and then spits it out later, or if you check to see if he swallowed it, he throws it up afterward. But if that is the case and he still has a daily addiction, he is a very careless person. If you know it is oxy that he is buying, he might either be selling them or taking them, and either way you need to confront him about it

And of course, no amount of oxy will block naltrexone (especailly if he is taking the 50mg pills)

 

[phr]

Yeah, all research/anecdotal evidence suggests there's is absolutely no getting high from Opioids while on a Naltrexone regimen.

Could be something other than Opiates he's texting about... Benzodiazepines maybe?

I was under the impression that given a large enough dose with the proper opiate, you can break through it. Sort of like breaking through methadone, or not being administered enough naloxone to reverse an OD.

I'm not saying you're wrong, just curious...

 

[morphonorconic]

^Maybe... Now I'm curious too.

An Opioid like say Buprenorphine, with a very strong binding affinity, would accordingly have a better chance at out-competing the antagonist [blockade], if anything was going to. However, it is my understanding that 50mg of Naltrexone taken daily will effectively saturate the available receptors, and subsequently prevent the binding of any commonly used/abused full agonists, such as Oxycodone, and even at high doses.

 

[my84firebird355]

Yes, you can absolutely "override" naltrexone, problem is - you would most likely OD WAY before you actually broke that barrier. this is a user friendly explanation of how it works (to the best of my knowledge)

all opiates have whats called a "binding affinity" this represents a sort of heirarchy of opiates which bind to your receptors. so to put it simply - heroins binding affinity is lets say 10, and naltrexones affinity is lets say 100 - which means that if you have heroin in your system and take naltrexone the naltrexone will boot the heroin off your receptors because of its higher binding affinity. so imagine your receptors as a bunch of chairs, heroin (or other short acting opiates) are these whimpy guys and naltrexone are these really strong guys. now these really strong guys are sitting in the chairs, and dont plan on moving, however if you get enough whimpy guys together they will obviously kick the big guys off, but you have to get like 11 times more whimpy guys (your dose has to be like 11 time bigger then normal) to kick off the bigger guys, and most people don't have the tolerance to handle that so they OD and die.

hope that helps =)

 

[8L4YN3]

I've heard nothing but bad reports about naltrexone regimens.