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Naltrexone and ayahuasca

A

Ayahuascalobster

Greenlighter
Joined
Jan 27, 2017
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I'm planning on taking ayahuasca in the next two weeks. I take naltrexone for alcoholism. I drink like 1 beer on occasion thanks to naltrexone but no more than that. Do I have to stop naltrexone to take ayahuasca. Couldn't find much information on interaction. And how long should I stop it for if I do. If I stop naltrexone I won't go back to drinking alcoholically for months. I'm only saying this because I know ayahuasca and alcohol has a serious interaction and I will avoid alcohol within 48 hours of taking ayahuasca.
 
Btw I'm taking Syrian rue and Acadia confusa. I just read another thread that said this isn't technically traditional ayahuasca but I've done it before and had a blast with these plants. So yeah.
 
I can't seem to find anything about the interaction of naltrexone with MAOIs, but if you feel you're able to stop it without relapsing, I would go ahead and stop it, as there may be an interaction and I think it would be best to go into ayahuasca with the most naturally functioning mind possible.
 
I've done two ayahuasca ceremonies and they were very powerful and helped me a lot with a number of my issues. Unfortunately, one of my issues was alcoholism and I have since relapsed. Due to this relapse, my doctor has me on naltrexone, a drug to curb alcohol cravings. It is an opioid antagonist. I am looking to do another two ceremonies at the end of March. However, I have not read much about naltrexone interaction with ayahuasca. I am well aware you can't be on MAO-Is or SSRIs. If anyone has any information on naltrexone, any help would be greatly appreciated.

u/0catfish0 (reddit)

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Naltrexone or Naloxone will not have a drug interaction with Ayahuasca. The opiate receptors that are 'plugged' by Naltrexone are not probably not implicated in Ayahuasca drug effects.

However, I don't know of any clinical studies that support my claim as this is just speculation. It's absolutely possible there there is some relationship between GABA and Glutamate and Ayahuasca but I don't know if that's been studied extensively or at all.

-YogiBarelyThere (reddit)

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Painkillers synthesized from thebaine (buprenorphine, etorphine, oxycodone, oxymorphone, nalbuphine, naloxone, naltrexone) should also be regarded as highly dangerous to combine with MAOIs.

http://sananda-wasi.com/meds-to-avoid-with-ayahuasca/
 
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