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Opioids Naloxone & Binding affinity

tricomb

tricomb

Bluelight Crew
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Jan 21, 2012
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Does anyone have a link to a chart comparing the binding affinities of opiates?

Can naloxone reverse the effects of super potent opioids like bentley compounds, etorphine etc.
 
i know buprenorphine has a higher binding affinity than it, so it can't reverse too much suboxone/subutex/temgesic/buprenex.. you get the point lol.
so look up the binding affinity for bupe and then you will know that naloxones is lower but wont have an exact number though, i am sure it's not too hard to find different affinities for different opiates.
 
I know for a fact that sufentanyl can out-compete buprenorphine, so I know it would be able to break through naloxone.. I'm going to look up a chart now.

Update//
Still looking...

This is pretty interesting, though its a bit hard to understand.

okay- further research lol:
naloxone is not effective in treating overdosages of super potent opioids like etorphine or carfentanil, Diprenorphine is commonly used, and is the strongest opiate antagonist that is available.
 
Last edited:
I am sure naloxones affinity is less than bupe ... Naloxones is less than fentanyl ... I would think that no... If someones of-ing on one of those ridiculously strong ones ( carfent, Bromadol... Etc) that naloxone would b useless. But hey maybe I am wrong. Good question.
 
Znegative said:
I know for a fact that sufentanyl can out-compete buprenorphine, so I know it would be able to break through naloxone.. I'm going to look up a chart now.

Update//
Still looking...

This is pretty interesting, though its a bit hard to understand.

okay- further research lol:
naloxone is not effective in treating overdosages of super potent opioids like etorphine or carfentanil, Diprenorphine is commonly used, and is the strongest opiate antagonist that is available.
Click to expand...

Thankyou!! Would diprenorphine cause a more violent precipitated WD if administered? like even with less-potent-than-carfentanil opiates like heroin?
 
Well, I imagine it wouldn't be too different, I mean, an antagonist is an antagonist when it comes to opiates/opioids like morphine/oxy/heroin etc... Perhaps it might rip it off faster, but I don't see how it could make you feel worse. It is interesting though, I would like to try Nalbuphine, its also an agonist/antagonist but it has a pretty high binding affinity from what I gather. I wonder how it would work on top of a low dose of buprenorphine.

Diprenorphine would not be easy to get like naloxone or naltrexone though, it is CII for some reason (perhaps it can by converted easily into a super potent full agonist, who knows.)
 
Yeah, naloxone can be converted into oxymorphone in a lab pretty easily.

I'll bet diprenorphine is used more often in veterinary applications.
 
Right, since it's used to antagonize drugs like carfentanil and etorphine (which are used to basically put down elephants). I wouldn't want to know what kind of monster you'd be able to make out of it lol.
 
^thats for sure. What a mess, imagine simultaneous gassing with Diprenorphine and fentanyl.. Yikes..

I can see some guy coming across a vial of Diprenorphine somehow and thinking it was an opioid agonist (I mean, the name sure sounds like one) what a sad, and painful surprise that would be.
 
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