MXE neurochemisty activity?

[blakmike]

Has this ever been resolved?

I remember fools saying it had opiate activity when it first came out. But I know that's not true

I read some report about how you could bond things to a basic PCP molecule to affect Serotonin receptors, Dopamine receptors, and even Opiate receptors.

I think it indeed has a little dopaminergic activity and heres why: After using it daily all day long for way too long, I can get no dissociation from the chem at all anymore, well in normal doses, I was not about to bomb 150mg to see what happened. But out of habit and listening to that sweet sizzle and tasting that wonderful vapor (the taste of lung cancer? I hope not), I kept on using my last batch. I found that after 4 or five deep hits 75mg maybe?, it gave me a neat little rush that lasted for about 15 mins.

 

[sekio]

A recent ECMD study said that MXE has activity at SERT and at NMDA, nothing else significant. So there is no opioid or dopamine affinity.

 

[laCster]

Sekio is right, we all thought mxe had DAT affinity and opioid activity, but sadly that's not true

 

[hatrix]

A recent ECMD study said that MXE has activity at SERT and at NMDA, nothing else significant. So there is no opioid or dopamine affinity.

So what was all the fuss then with combinations involving other drugs with high SERT affinity. Not saying you are wrong by any means, just would like to understand why some people reacted to badly to combos like MDMA + MXE.