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MXE for MDMA comedown? Serotonin Syndrome Dangers?

Tryptamino

Tryptamino

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I already tried asking this question in the B&D MXE mega thread, and got little response.
This friday I am thinking of taking MDMA combined with 4FA, and am also getting some MXE. I want to take the MXE on the comedown, but I'm not sure if it's safe, becuase I've heard something about combining MDMA with NMDA agonists causing serotonin syndrome. Is this safe? Should I wait on the MXE?
 
just take a benzo for the comedown, no point in risking serotonin syndrome

I've also heard 4-fa and mxe isn't the most pleasent combo either
 
Why do you need the 4-FA? I'd imagine that the 4-FA would only make the comedown worse and keep you from sleeping. Instead of taking the 4-FA and the MXE, why not just take the MDMA and have a beer and a little weed on the comedown?

4-FA seems more useful to get chores/homework done than for a night out, but maybe I'm just biased since (to me) it has a weak euphoria and nasty side effects.

Ok well how many days should I wait before taking the MXE?
Click to expand...

Depends on how safe you want to be, but I think most people would agree that the next day (after a nights rest) would be fine. MAOIs are a different story. Personally, I've seen people take MXE with everything, IN LOW DOSES... that means key bumps of MXE with fingerdips of MDMA. You're mileage may vary, though, so I commend you for taking the intelligent approach and starting this thread.
 
You should read this thread. It has a lot of information from people who did different combinations of MXE and other compounds:

Methoxetamine-Subthread-Combinations

The deal with MDMA and other similar PEA's are that some people have had really bad reactions, while others have found it to be a fine combo. Nobody really knows why, so tread with care.
 
I have to agree with everyone here, don't try this mix, or, if you do, go EXTREMELY easy on the mxe. I've had as little as 10mg post-stim use & suffered a racing heart, palpitations, anxiety & tension & was completeky unable to relax. My stim dosages are alway very controlled so I put the problem down to the mxe.

Mxe does NOT mix with stimulants, before, during or after. I do not recomend it's use in this way!
 
nonnihilnitoris said:
[...] I think most people would agree that the next day (after a nights rest) would be fine.
Click to expand...

I have tried MXE the day after MDMA without rest, and got negative effects. My rule became one day spacing in between, but the lack of sleep could be the factor as well, now you mention it.
 
4-fa and mxe (low dose of mxe) seemed really powerful and gave me a hangover the next day, however, mxe doesn't have anything to do with serotonin so it should be fine.
 
Me and a friend have tried mxe and mdma together and got hives (not extremely serious) the next couple of days on the 3 occasions of use
 
I did mdma shrooms, 4homet and mxe at a festival, i topped it off with some changa with harmalas.

i was totally flipping out like i usually do on mdma, did a very stupid and possible lethal combo, but i was fine though, had a great time and the mxe made the overlap from coming down on molly into mexxy land, also by then the 4homet atually elt something without getting overpowered by mdma and tolerance.


After this i was dead tired for a week though, will never ever mix stupid shit again, i rarely do mdma nowaday since it makes me very reckless.
 
I tried this recently. I took about a 50 mg dose of mxe at a festival once the mdma started to ware off. It went like a standard mxe trip until i smoked some weed then suddenly i had the most horrible trip of my life thinking i was going to die. Many things could have affected this, bottom line is I won't be trying that combo again.
 
took 30mg mxe during the comedown of 120mg 6-apb. no physical problems, but i ended up staying up all night into the next day with massive mindfuck. pretty awesome
 
Mxe is my favourite of all drugs and I've tried all sorts of combos. I've mixed it with a vareity of phenethylamines and tryptamines. Id watch with the dosing I can easilly handle 150mg mxe on its own but when I mixed that volume with just 50mg of MDMA I had a uncomfortable feeling of pressure im my temples that lasted for a couple of days after (not the nice pressure that usually acompanies MXE) and I spent the first hour of my trip feeling really un comfortable until i eventually passed out and woke 90 minutes later feeling terrible. ive since found that 30-40mg of mxe and and about a quarter of my normal dose of anything else is perfect for me. MDMA and mxe is not all that remarkable but 9 mg of 2cb had me feeling all over body orgasms for 2 hours and the most colourful CEV's ive ever seen id highly reccomend it.
 
Mxe is my favourite of all drugs and I've tried all sorts of combos. I've mixed it with a vareity of phenethylamines and tryptamines. Id watch with the dosing though I can easilly handle 150mg mxe on its own but when I mixed that volume with just 50mg of MDMA I had a uncomfortable/painful feeling of pressure im my temples and I spent the first hour of my trip feeling really un comfortable until i eventually passed out and woke 90 minutes later feeling awful. ive since found that 40-50mg of mxe and and about a quarter of my normal dose of anything else is perfect for me. MDMA and mxe is not all that remarkable but 9 mg of 2cb had me feeling all over body orgasms for 2 hours and the most colourful CEV's ive ever seen id highly reccomend it. I've not felt anything resembling SS so I shouldn't worry about it too much. just watch your dosing and you should be fine.
 
I've done this with doses of MXE less than 30mg quite a few times, either before or after a sensible, single dose of MDMA, usually ~120mg.

It pleasantly amplifies the feeling of floatiness and lowers the lucidity, an effect most people just dose more MDMA to achieve



It's worth noting that MXE has mild SERT affinity which is more likely to be as an SRI than an SRA. this means it will actually decrease MDMA neurotoxicity and sensible amounts cause no concern for serotonin syndrome.

Given the wide binding profile of MXE and previously observed peculiar interactions I would warn against mixing high doses of either with the other but in moderation one should be just fine.
 
Transform said:
I've done this with doses of MXE less than 30mg quite a few times, either before or after a sensible, single dose of MDMA, usually ~120mg.

It pleasantly amplifies the feeling of floatiness and lowers the lucidity, an effect most people just dose more MDMA to achieve



It's worth noting that MXE has mild SERT affinity which is more likely to be as an SRI than an SRA. this means it will actually decrease MDMA neurotoxicity and sensible amounts cause no concern for serotonin syndrome.

Given the wide binding profile of MXE and previously observed peculiar interactions I would warn against mixing high doses of either with the other but in moderation one should be just fine.
Click to expand...

this, mxe after coming off an mdma peak is so wonderful, but remember you still have another drug in you so keep the dose small. when i do this its 125mg mdma and 30mg mxe
 
Transform said:
I've done this with doses of MXE less than 30mg quite a few times, either before or after a sensible, single dose of MDMA, usually ~120mg.

It pleasantly amplifies the feeling of floatiness and lowers the lucidity, an effect most people just dose more MDMA to achieve



It's worth noting that MXE has mild SERT affinity which is more likely to be as an SRI than an SRA. this means it will actually decrease MDMA neurotoxicity and sensible amounts cause no concern for serotonin syndrome.

Given the wide binding profile of MXE and previously observed peculiar interactions I would warn against mixing high doses of either with the other but in moderation one should be just fine.
Click to expand...

Id advise against a high dose of mxe when mixing with any drug i just tend to end up with an awful feeling of pressure in my head and end up blacking out especially with serotonergic drugs. If mxe does act as an Sri it would indeed help guard against neurotoxicity of the drug but would this not also increase your chances of developing SS? I'm sorry if this is a silly question what little I do know about SS i've only really learnt from what ive read on here and the net and quite often i get myself confused when talking about ssri's and moai's as to their roles.
 
I've taken mxe the day following mdma or similar things to help with the subjective experience consequent to the monamine deficit. The odd reports from others concerning the combo, its SERT affinity & the wild variations in mxe purity have put me off trying it for the time being. It does help the day after though, for me at least.
 
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