For a while after 1970, Panaeolus subbalteatus had become the third most popular free high mushroom in the United States after Psilocybe cubensis (the "gold top") and Psilocybe semilanceata (the "liberty cap"). Andrew Weil wrote about the popular use of Panaeolus subbalteatus in the Pacific Northwest in his book The Marriage of the Sun and Moon.
By 1976, Jonathan Ott, Jeremy Bigwood, Gastón Guzmán and Andrew Weil, all described Panaeolus subbalteatus as a popular recreational drug and in 1977 Andrew Weil wrote that "during the spring and summer months when the "liberty caps" are not available, Oregonians can use another variety of psilocybian mushroom in the genus Panaeolus. It is easily picked in quantities on piles of rotting hay in manured cow fields in the Willamette Valley. This mushroom is twice as fleshy as the "liberty cap", even though it is less potent. The dosage (when fresh) for both species, is similar depending on the size of the mushroom. Usually about twenty to forty mushrooms are sufficient for producing the desirable effects similar to that of the Psilocybes and Copelandias." Weil also mentioned that, "moreover the quality of the effects are not as good. When fresh it has been known to produce symptoms of mild toxicity, and sometimes nausea has been known to occur. I felt uncomfortable and quite restless after eating this variety. Drying them seems to curb some of the toxicity but not all of it. It is also not as visual in context as [are] other varieties. None the less it is quite popular in the warmer months."
Although Dr. Weil's experience with this species was not up to his expectations, clinical research on human volunteers has proven that Panaeolus species are more tranquil and less toxic in nature to humans than their cousins the Psilocybes. A clinical dosage for Panaeolus subbalteatus would be three to five grams of dried material or one fresh ounce. This would be equivalent to the same dosage for Psilocybe cubensis. One fresh ounce of Panaeolus subbalteatus would be approximately five to thirty fresh mushrooms depending on their size.
And in the 1950s, Dr. Sam I Stein, conducted a study of a man who had homosexual tendencies and was able to cure him of his desires by using Panaeolus subbalteatus and Psilocybe caerulescens in a clinical therapeutic setting. A rarity and Stein reported that the subbs were more tranquil that the psilocybes.
I might add that Dr. Stein was the first reported case of a mushroom bad trip. He ate five dried grams of in vitro grow P. cubensis and had a very heavy dysphoric reaction to the dosage.
mjshroomer.
So Weil's comments on the uncomfortable side effects he claimed to experience is one in a million. Maybe obtaining his personal notes of the incident and of other he appears to be aware of then maybe an investigation is in order.