I almost posted a reply with dpt in mind rather than diphenhydramine.
Benadryl on its own can get a little psychotic in hefty doses. Although it's just my opinion, I feel like a large dose of 'dph' mixed with a psychedelic will result in you becoming that guy who streaks naked whilst screaming gibberish and eventually ends up in a confrontation with the towns collective police force and then strapped down to a hospital bed with no recollection of the past couple hours. I've read plenty of reports of people being unable to discern blatant hallucinations from reality whilst frying on diphenhydramine. Throw a potent psychedelic into the mix and you might lose control. A common hallucination I've read (and experienced on a 100mg dose myself during a bout of insomnia) is spiders covering the walls of the room.
Also expect to be overly nauseous, dizzy, dehydrated, all with a feverish body temperature.
I do not recommend this combo in the spirit of hr.