2Cs have hit me harder than the tryptamines I tried (cept mushies at times), in my limited experience. Tryptamines have mostly always been nice enough to me. Easier on me. 4-AcO-DMT feels loving. So far. Happy. 4-HO-DET a little rough around the edges but there is still a nice center to it. Something about tryptamines just feel a lot more at home with me. Phens mean business. They are also much harder on my body, and usually feel like shit or like I'm in danger of some kind of cardio issue... And perhaps this sparks certain spiritual experiences. But I just remember them hitting me there more.
But I feel wrong saying "more spiritual". I'd like to take 60 mg of 4-AcO-DMT

or more. The phens I took have all been huge dosages that are giving me these memories. I never had a scale back then, messing with 2C-E and D, and 25D I was rather idiotic and thought I could handle 2.4 mg off the bat... thought I still wouldn't consider that one so "spiritual"... But I am... And used it.
DOC gave me one very powerful experience, when I let it... But I was a younger body then. That was one of the first times I felt without a doubt "spirits" around me. Other times I have been suspicious... But this was insane, the feeling. I also felt rather "psycho" at times. Cracked.
I would choose 4-AcO-DMT. It was a great experience, my one time really going into it. Saw some white light. Love.
There are many aspects of spirit. Different things might be used at different times. Sometimes this drug that drug.. sometimes its an opiate and not a psychedelic. Sometimes its a cigarette. Sometimes not drug. Sometimes music. Sometimes Christmas.