zombiesarepeaceful
Bluelighter
I only said dxm cuz its kicked my ass and slaughtered my ego many times over..and taught me a bunch of stuff while trippin.
Most Powerful or Potent Psychedelic
- Thread starter Visionary_Kpsycho
- Start date
qwe
Bluelight Crew
^have you tried ketamine?
zombiesarepeaceful
Bluelighter
^no..can't find it around here.
zombiesarepeaceful
Bluelighter
^How do you mean forever? Flashbacks? Cuz I've gotten dxm flashbacks..*shudder*
I meant acid changes your perception of the world and your personality... and this seems to last forever, where as other drugs do not. For example, while on E, you might become more open as a person, but that seems to last only while you are rolling.
johanneschimpo
Bluelighter
real psych or chemical masturbation? IUPAC name is a bitch
Vanadium said:
remi is not potent it is simply a soft drug version of the fentanyl family which is extensively metabolised by plasma esterases, incidentally unless the law has been changed I believe remifentanyl analogues are UK legal
Carfenta or sufenta or beta hydroxy are the really potent ones
as for extremely potent AND powerful: some analogues of QNB (BZ) are fully active at less than 10 micrograms in 100kg adults and produce complete delerium and real hallucinations for 48 hours or more
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MattPsy
Bluelighter
- Joined
- Jan 15, 2006
- Messages
- 1,616
Vanadium... haha yeah that'd have very high affinity :D , was gonna post something like that but then had a can't be fucked moment when it came to the diagram 
. But don't forget that high affinity doesn't always mean high activity! It'd need to be a full agonist, as well as being capable of activating Gi/o and Gq/11 signalling! Some 5-HT2a agonists are devoid of psychedelic activity. It seems that activation alone isn't enough. It's /how/ you activate that receptor. Complex conformational changes lead to different G-protein activation 
.
vecktor, i'm pretty sure that sort of structure has been made and evaluated, and was found to have VERY high affinity, can't remmeber the paper right at the moment though. The 2-methoxy moiety bonds to a different amino acid residue,
. But don't forget that high affinity doesn't always mean high activity! It'd need to be a full agonist, as well as being capable of activating Gi/o and Gq/11 signalling! Some 5-HT2a agonists are devoid of psychedelic activity. It seems that activation alone isn't enough. It's /how/ you activate that receptor. Complex conformational changes lead to different G-protein activation .vecktor, i'm pretty sure that sort of structure has been made and evaluated, and was found to have VERY high affinity, can't remmeber the paper right at the moment though. The 2-methoxy moiety bonds to a different amino acid residue,
dbailey11
Bluelighter
morninggloryseed said:
Would you mind explaining what diethylazetidine is? I tried looking it up on Google but didn't find anything.
Morninggloryseed
Bluelight Crew
dbailey11 said:
I'll go one better, and reproduce the structure. Forgive me for not being specific as to which isomer of this is represented. I can't remember which (cis or trans) is the more potent isomer. Also forgive me for causing confusion, as it is the dimethyl and not the diethyl that nichols studied.
dbailey11
Bluelighter
Thanks.
nuke
Bluelighter
- Joined
- Nov 7, 2004
- Messages
- 4,191
morninggloryseed said:I'll go one better, and reproduce the structure. Forgive me for not being specific as to which isomer of this is represented. I can't remember which (cis or trans) is the more potent isomer. Also forgive me for causing confusion, as it is the dimethyl and not the diethyl that nichols studied.
It's the S,S-dimethylazetidine analog that is the most potent, the cis and R,R-dimethylazetidine analogs were made but were less potent than LSD.
edit: here's a 3d pic so the geometry can be better seen in this analogue. this molecule is more potent hallucinogenically than any of the previous analogues created.
edit 2: whoops, that's the l isomer, but you get the picture
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