Most Euphoric Stimulant?

[TheLightBringer]

dextro-Amp snorted was not anywhere close to racemic. Surprise, all the work for NADA. Did a extraction once.

It didn t work out as expected, i experienced no benefit what-so-ever.
Weird as it is essentialy Speed but apperetly the l-isomere does effect the up.
D- i consider functional, racemic is tricky as it s dose dependend ime.
Funtional <-> Recreational, and snortable => RECREATIONAL or i have a fetish.

I fully agree the L-isomer adds a lot depending on ROA regarding ”rush”. Altough that is most pronounced IV, the difference in IV D-amph and IV racemic amph is big

Differential effects of amphetamine isomers on dopamine release in the rat striatum and nucleus accumbens core - PubMed

These data support the hypothesis that amphetamine isomers have different effects on release of DA from nerve endings. It is possible that L: -amphetamine may have unique actions on the DA transporter, which is required for the effects of amphetamine on DA release from nerve terminals.

pubmed.ncbi.nlm.nih.gov

This is the only study I could find but apparently it has some unique interaction with the dopamine transporter I assume L-isomer improves the rate of dopamine release in the presence of D-Isomer

 

[4DQSAR]

I only just remembered that in spite of their chemical similarity, the way amphetamine and methamphetamine works are significantly different. One acts at the reserpine site, the other at the tetrabenzapine site. I forget which way round it is.

I suppose amphetamine IS an active metabolite of methamphetamine, so maybe that alters the subjective effect beyond the fact that the secondary amine is more basic and that methyl will improve LogP a little.

 

[TheLightBringer]

I only just remembered that in spite of their chemical similarity, the way amphetamine and methamphetamine works are significantly different. One acts at the reserpine site, the other at the tetrabenzapine site. I forget which way round it is.

I suppose amphetamine IS an active metabolite of methamphetamine, so maybe that alters the subjective effect beyond the fact that the secondary amine is more basic and that methyl will improve LogP a little.

Please provide the study id like to learn

 

[BadBoy377]

Mr @4DQSAR , have you tried original MCAT then? Methacathinone?

 

[getcolor728]

So, as someone who indulges in stimulants more than any other drug type, I have so far collected many great experinces.
I can tell you so far, that Methamphetamine is up there on this list, but there are other newcomers that need mentioning.

So let's start with Propylhexedrine, a completely legal stimulant available OTC. Now extraction of this guy from the inhalers is not pleasant and the oily camphor smell can be nausea inducing, however, the high, after a 300mg+ dose is very good, when I say very good, I mean Methamphetamine with more adrenerguc effects, like 1:1 identical, had very experiences with Propylhexedrine.

Aminorex is another one. Very Amphetamine like, however it has at large doses has this effect I call "The Craze" it affects a receptor known for Primal Insticts (something certain Viruses bond to) very cutting edge stuff, great Aphrodisiac.

So Meth is in the top 3, but the most Euphoric stimulant I have ever tried is actually Prolintane (KATOVIT), had nice yellow pills of it in a drawer, and decided to base them and smoke, and Whoaa. Craziest Dopamine explosion in brain ever, a sense absolute "Master of Universe" kind of wellbeing, very smooth and pleasant stuff.

Am yet to discover 4-Methylaminorex, am told great about it.

Oh yeah, 4-flouroamphetamine, bloody gorgeous stuff, up there with Meth.

The other guy I discovered to be in the top 3 after Prolintane is interestingly Ethylphenidate, man if I had a small tub of that guy, I would indulge in that passionately all day.
Much love
-O

Does meth or any other stims give a tingling sensation all over your body for you?

 

[4DQSAR]

Mr @4DQSAR , have you tried original MCAT then? Methacathinone?

Yes. But it was over thirty years ago. Not great. It wasn't sometihing I would take twice. I think I just gave the rest away. Back then novel was, well, novel. So some people were curious. None were that thrilled. Similarly I made some GHB (when it was legal to do so) and I just couldn't work out why decades later it would still be so popular.

 

[DrChivago]

I've always found Cocaine to have the best euphoric effects especially when it effects your libido at the same time! But it's got to be very good Coke like 80%+ purity.

THIS RIGHT FN HERE.

Use some pure intravenously just once, and for 10 MINUTES STRAIGHT...

Whaa-Wha-WAh-WaH-wAh-WhaA-Wha-Wah-Wa-WA-waH-WhAh.

With a big-ass grin and rock hard pecker.

YOLA FTW.

 

[emkee_reinvented]

Yes. But it was over thirty years ago. Not great. It wasn't sometihing I would take twice. I think I just gave the rest away. Back then novel was, well, novel. So some people were curious. None were that thrilled. Similarly I made some GHB (when it was legal to do so) and I just couldn't work out why decades later it would still be so popular.

If the world end s, thread recently. GHB and also Methylone [the best Cathinone].
Emphatogen, not a stimulant but sloppy,. Experience s are mixed.
Sometimes glowing, MCAT seemed also to expose this character ?
Maybe it missed balance, like Amphetamine vs Meth-Amphetamine.

GHB was on my list, 25/ 50 gram [Shit i forgot a scale no way i am eyeballing.
Not even when tolerant especially as i intended to share that imagery day].
That is how much i appreciate it.

In contrast in that 'not to bad sounding Doom-Scenario'. Wonder if we get to do a binge before the whole shit-house goes up in flames. In reality.
On the list also Oxycodone, but with 10 x 5 mg and 1 gram racemic Ketamine.
Obvious of lesser significance to me, Oxy for novelty.

The hunger to know isn t precisely a blessing.
It hurt s at times knowing you will miss a lot.

 

[BadBoy377]

Yes. But it was over thirty years ago. Not great. It wasn't sometihing I would take twice. I think I just gave the rest away. Back then novel was, well, novel. So some people were curious. None were that thrilled. Similarly I made some GHB (when it was legal to do so) and I just couldn't work out why decades later it would still be so popular.

Yeah, I found it highly variable even at the same dose. Most of the time it was just stimulation without focus. Maybe one in four times it could be great. I had loads of it lying around at one point. Definitely depends how good your synth was. But the good stuff could be good. But not predictably so. A good pinch topping a bowl of weed worked well as a good addition to your night in/out.

Definitely had some positives if you didn't have any other decent drugs to hand. At the end of the day it's nothing compared to meth.

 

[TheLightBringer]

@4DQSAR @BadBoy377 Did you get around to trying L-MethCathinone? If so how did it differ from racemic?

 

[4DQSAR]

@4DQSAR @BadBoy377 Did you get around to trying L-MethCathinone? If so how did it differ from racemic?

Well, it's chiral by nature. It doesn't matter if you oxidize ephedrine or pseudoephedrine, I assume you get the chiral product.

I don't think any products containing the appropriate amino-alcohol for the other isomer are available.

It wasn't as it I really experimented with the stuff. It was a stimulant and one taste showed it to be OKish, just not something I could imagine being worth exploring.

 

[deficiT]

a-PHP generally just dropped ~50mg in a light bulb or pipe and smoked as much as I could til it was gone then rinse and repeat all night long into the next day then into the night getting stuck in the same spot for hours until I went psychotic…

Yeah, I had many of those kinds of nights with a-php and a-pvp. It is insane how compulsive they are. When I first got into taking those more heavily I was very drawn into that compulsion. I did such absurd amounts IV, and I'm honestly surprised I don't have any lasting physical effects from them. I do think they fucked up my head a bit. The hallucinations from those drugs seem far more "real" than basically any other drug I've used. When combined with Dissociatives, you really are in for a head fuck

 

[TheLightBringer]

Yeah, I had many of those kinds of nights with a-php and a-pvp. It is insane how compulsive they are. When I first got into taking those more heavily I was very drawn into that compulsion. I did such absurd amounts IV, and I'm honestly surprised I don't have any lasting physical effects from them. I do think they fucked up my head a bit. The hallucinations from those drugs seem far more "real" than basically any other drug I've used. When combined with Dissociatives, you really are in for a head fuck

Oh totally agree, the state I ended up in after a binge of a-PHP, amphetamine, 3-MMC, 3-MeO-PCP, ketamine and cannabis was something else, Im surprised my mind came back from that

 

[emkee_reinvented]

Well, it's chiral by nature. It doesn't matter if you oxidize ephedrine or pseudoephedrine, I assume you get the chiral product.

I don't think any products containing the appropriate amino-alcohol for the other isomer are available.

It wasn't as it I really experimented with the stuff. It was a stimulant and one taste showed it to be OKish, just not something I could imagine being worth exploring.

Stimulant barely but Ok i agree on that, but Ephedra extract a normal dose was more stimulating ime. Could be body chemistry, it seem s the term Sloppy that was used in US reports of early use of DIY made MethCathinone. But it fitted my experience s with Khat/ Cathinone/ Cathine and bk-MDMA.

But it seems not generally agreed that Cathinone s are that good as i experienced em.
Nobody in my circle liked, Khat. And no one sought Methylone. But they didn t care for 2C-B or psychedelic either. So different taste s exist, everyone got a diff flavour, mine differs more !

The more for me right.

 

[deficiT]

To the original topic, idk I've done a crazy amount of stimulants at this point in my life, but I'd really just have to go with the classics in terms of what is most directly euphoric.

Methamphetamine, dextroamphetamine, and cocaine. Obviously they have quite different nature's, durations, and effects, but any less common or RC stimulant I've tried essentially just falls short of those drugs for one reason or another

Methamphetamine sorta gave me a superhuman drive and precision that is unparalleled to anything else. Until you eventually do a bit too much or stay up too long and start getting cognitive paralysis and shit

Cocaine has the strongest and most perfect acute effects or rush, regardless of ROA. I'm talking about good quality cocaine of course. Moreso than most other drugs, shitty quality cocaine is really a different experience and not all that great, which is probably why some people have such lukewarm experiences with it, as shitty cocaine is prevalent and also expensive. Taking a nice bump that makes me want to just lay back and feel good is one of my favorite feelings, and I think Cocaine is really the only drug of abuse that I have any desire to ever do again for those reasons.

Dextroamphetamine I've found to be basically the perfect drug that can be used regularly without a bunch of shitty drawbacks or negative effects. There is a lasting euphoria that doesn't seem to compel me to just keep taking more, unlike most other stimulants. It's much more pro-social and productive than any other stimulants for me, which i believe to be a facet of "euphoria" generally. I have ADHD and have now been prescribed amphetamines for many years, and I consider it to be a primary reason that I still function well despite all the dumb shit I've done and put in my body. Once I got medicated, my desire to use most other stimulants and do dumb shit pretty much evaporated.

 

[Deleted member 576750]

BDD->DC

 

[emkee_reinvented]

To the original topic, idk I've done a crazy amount of stimulants at this point in my life, but I'd really just have to go with the classics in terms of what is most directly euphoric.

Methamphetamine, dextroamphetamine, and cocaine. Obviously they have quite different nature's, durations, and effects, but any less common or RC stimulant I've tried essentially just falls short of those drugs for one reason or another

Methamphetamine sorta gave me a superhuman drive and precision that is unparalleled to anything else. Until you eventually do a bit too much or stay up too long and start getting cognitive paralysis and shit

Cocaine has the strongest and most perfect acute effects or rush, regardless of ROA. I'm talking about good quality cocaine of course. Moreso than most other drugs, shitty quality cocaine is really a different experience and not all that great, which is probably why some people have such lukewarm experiences with it, as shitty cocaine is prevalent and also expensive. Taking a nice bump that makes me want to just lay back and feel good is one of my favorite feelings, and I think Cocaine is really the only drug of abuse that I have any desire to ever do again for those reasons.

Dextroamphetamine I've found to be basically the perfect drug that can be used regularly without a bunch of shitty drawbacks or negative effects. There is a lasting euphoria that doesn't seem to compel me to just keep taking more, unlike most other stimulants. It's much more pro-social and productive than any other stimulants for me, which i believe to be a facet of "euphoria" generally. I have ADHD and have now been prescribed amphetamines for many years, and I consider it to be a primary reason that I still function well despite all the dumb shit I've done and put in my body. Once I got medicated, my desire to use most other stimulants and do dumb shit pretty much evaporated.

Is the strength of the rush important or a distraction. Kinda goes for ROA to.
Is smoking, boofing or IV-ing better the oral. That is questionable imo.

I hate Methylphenidate Oral even more then snorted Cocaine. They all belong in the same family as sublingual Cathinone, oral dextro-Amhetamine/ Ephedra extract and snorted Speed. To me the speed of onset is of less significance then the overal effect.

 

[4DQSAR]

The thing is about all the other cathinones is that they are a raecemate of the two enantiomers.

To the best of my knowledge nobody has resolved any of them to see if something that's only so-so as a raecemate is better if the product is just one enanriomer.

 

[TheLightBringer]

The thing is about all the other cathinones is that they are a raecemate of the two enantiomers.

To the best of my knowledge nobody has resolved any of them to see if something that's only so-so as a raecemate is better if the product is just one enanriomer.

Ive always wondered how S or R 3-MMC and 4-MMC would be. Altough I wonder how most RC stims or some psychedelics would be if they were enantiomerically pure

D-Threo-Ethylphenidate sounds like an amazing NDRI
The corresponding more active enantiomer of the pyros would probably be wonderful as well

Methylone, other phenidates, the DOx, TMA and 3C-x families and so on…

 

[cleft]

The thing is about all the other cathinones is that they are a raecemate of the two enantiomers.

To the best of my knowledge nobody has resolved any of them to see if something that's only so-so as a raecemate is better if the product is just one enanriomer.

It's believed that cathinones racemize with non-neutral pH and heat. If true, there won't be any difference.