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Most Euphoric Stimulant?

O

Oreon

Bluelighter
Joined
Oct 5, 2025
Messages
26
So, as someone who indulges in stimulants more than any other drug type, I have so far collected many great experinces.
I can tell you so far, that Methamphetamine is up there on this list, but there are other newcomers that need mentioning.

So let's start with Propylhexedrine, a completely legal stimulant available OTC. Now extraction of this guy from the inhalers is not pleasant and the oily camphor smell can be nausea inducing, however, the high, after a 300mg+ dose is very good, when I say very good, I mean Methamphetamine with more adrenerguc effects, like 1:1 identical, had very experiences with Propylhexedrine.

Aminorex is another one. Very Amphetamine like, however it has at large doses has this effect I call "The Craze" it affects a receptor known for Primal Insticts (something certain Viruses bond to) very cutting edge stuff, great Aphrodisiac.

So Meth is in the top 3, but the most Euphoric stimulant I have ever tried is actually Prolintane (KATOVIT), had nice yellow pills of it in a drawer, and decided to base them and smoke, and Whoaa. Craziest Dopamine explosion in brain ever, a sense absolute "Master of Universe" kind of wellbeing, very smooth and pleasant stuff.

Am yet to discover 4-Methylaminorex, am told great about it.

Oh yeah, 4-flouroamphetamine, bloody gorgeous stuff, up there with Meth.

The other guy I discovered to be in the top 3 after Prolintane is interestingly Ethylphenidate, man if I had a small tub of that guy, I would indulge in that passionately all day.
Much love
-O
 
Oreon said:
Aminorex is another one. Very Amphetamine like, however it has at large doses has this effect I call "The Craze" it affects a receptor known for Primal Insticts (something certain Viruses bond to) very cutting edge stuff, great Aphrodisiac.
Click to expand...

Could you please provide a study regarding this receptor known for primal instincts that certain viruses bind to
 
I've always found Cocaine to have the best euphoric effects especially when it effects your libido at the same time! But it's got to be very good Coke like 80%+ purity.
 
evo4ever said:
I've always found Cocaine to have the best euphoric effects especially when it effects your libido at the same time! But it's got to be very good Coke like 80%+ purity.
Click to expand...
Yeah, Cocaine sometimes works for me too. And when it does it's great
 
TheLightBringer said:
If youve had a-PVP or another pyrro how similar were they to prolintane? a-PVP is essentially beta-keto prolintane
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a-PVP is indeed similar, and in most sense just as nice, however side effect wise prolintane is easier and smoother.



Oh yeah, that Aminorex receptor study, I just rembered what it was about: basically Aminorex binds with high affinity to Orexin receptor, however another receptor called "Onorex-delta" receptor. It has Zombie like effects, but also causes insane Aphrodisia with Wild Euphoric effects. Can't find anything on it. Orexin is cool but the latter is definitely true about Aminorex too.

A-pvee has some downstairs effects unfortunately for me. The come up is strong but the down side is just as strong unfortunately.

-O
 
Oreon said:
Oh yeah, that Aminorex receptor study, I just rembered what it was about: basically Aminorex binds with high affinity to Orexin receptor, however another receptor called "Onorex-delta" receptor. It has Zombie like effects, but also causes insane Aphrodisia with Wild Euphoric effects. Can't find anything on it. Orexin is cool but the latter is definitely true about Aminorex too.
Click to expand...
So youre saying it acts as an Orexin receptor agonist on top of being a stimulant? Might show promise for narcolepsy, altough aminorex is quite cardiotoxic unfortunately
 
I have only tried meth, speed, coke, adrenal, Ritalin, Dex, Vyvanse

For me Meth wins for Euphoric and Horny
 
Preludin (Phenmetrazine) was apparently Significantly more euphoric & pleasurable (pro-sexual) than even IV injected Methamphetamine, by anecdotal reviews by actual users, genuine pharmaceutical studies / medical journal studies testing Phenmetrazine against Amphetamines, Methylphenidate (Ritalin), Cocaine, etc

It was actually voluntary removed by its manufacturer due to very high abuse rates and rampant abuse due to its unreal euphoric effects

d-Desoxyephedrine (Desoxyn) / Methedrine / Methylamphetamine obviously is top 3 if not tied with Phenmetrazine…..1950’s Pharma classics like Dexamyl & Desbutal (Meth & d-Amph + Barbiturates) is came capsule and IR tablets . Methedrine glass ampoules 20 & 30mg for IV/IM/SC administration….pharma grade Methamphetamine for injection

Ritalin (Methylphenidate) Yes, believe it or not CIBA Phamacuiticals had a 100mg glass vial for injection and IR tablets…..both Phenmetrazine (Preludin) & Methylphenidate (Ritalin) were VERY highly sought after by hi dose volume injection users, when its pharmaceutical grade API compounding powder was available (1950-1970’s approx)

With my EXTENSIVE drug use, dopaminergic stimulant, opioids, benzodiazepine, etc, etc…….only 2 drugs ever gave me True, undeniable, unmistakable, overwhelming powderfull EUPHORIA
1) Oxycodone
2) Ritalin (Methylphenidate)

Nearly identical in their euphoric ecstasy, the warmest blanket of comfort & happiness, like my CNS was climaxing with dopaminergic pleasure ….

Cocaine & Ritalin (Methylphenidate) compete for the same binding sites at the DAT/NET although Cocaine has significantly more SERT than Ritalin….both IV injecting users, some had difficulty differentiating between Cocaine & Ritalin ) …..same studies that participants had difficulty identifying Diacetylmorphine (Heroin) over Hydromorphone (Dilaudid) …..although theBaine derived/synthesized Oxycodone blows them both outta the water. Seriously.
 
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Prolintane for me was far less euphoric than alpha-pvp. When I had some, I used it as a functional sutimulant. Tried it a few times IV, but not very good, and lots of peripheral effects. Alpha-pvp was very euphoric IV, but then the voices, banging on the walls, and the fear kicked in. Like MDPV, the psychosis ruined the moment.
I’m surprised Ritalin keeps coming up. I mostly used ethylphenidate, which apparently metabolizes to Ritalin, and did not find it to be much fun. It also caused weird, psycho hallucination if too much was injected. Maybe that was the ethylphenidate since it probably metabolized more slowly, but it can’t be that much different. It is a good functional stim at modest doses.
Orexin is fascinating. I’m waiting for the antagonists to become cheaper as they sound much better than benzos for sleep. Never thought about orexin agonists. Sounds like most can be hepatotoxic…
 
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You mean…..when Ritalin is taken with Ethanol/Alcohol it produces the InActive metabolite l-Ethylphenidate and Ritalinic Acid

Ritalin (Methylphenidate) + Ethanol increases d-MPH (Focalin) levels by 40% significantly increasing its euphoric properties

20+ years on Methylphenidate its original euphoric bliss has faded….but initially it was AMAZING …..safest dopaminergic stimulant and extremely pleasurable

MDPV I’ve heard from many it’s soooo amazing. Never tried it myself but it must be if Pharma grade 100%;pure and or correct isomer
 
Oreon said:
.. but the most Euphoric stimulant I have ever tried is actually Prolintane (KATOVIT), had nice yellow pills of it in a drawer, and decided to base them and smoke, and Whoaa. Craziest Dopamine explosion in brain ever, a sense absolute "Master of Universe" kind of wellbeing, very smooth and pleasant stuff.
Click to expand...
It kinda over lapses with Cathinone the active in Khat/ Qat.
My favourite re-creative stimulant i discovered after a Amphetamine drought.
That left Cocaine and when i literally couldn tstand its effect s.
And swapped to Ephedrine better but only marginally.

Now is the 2-nd ring closed with Prolintane.
[3-rd position of the left/ top].
And the double bond where Cathinone has a tail after the first.
On prolintane is missing but has a whole appendix on the 2-nd.
And the whole ring is on a different spot the 3-rd.
Wonder how it feels pharmacology wise ?

Ok lets get dextro-Amphetamine. Well i am wondering on Prolintane.
The 2-nd ring is weird placed, should be on 2 to match em.
Side tail is also on it, yet it doesn t sound dirty.
I like it gonna check some more structure s,
interesting never went in so deep.

Lets compare to Pentedrone, loved that a bit too, snorted.
MDPV, probably any Pyro-Valerone. Or maybe the substitution s.
like Cocaine don t ring bell s in me. Body chemistry ?

Every body loves Coke, why not me ?
[Methyphenidate is has no benefits for me i rank it under Ephedrine,
and Cocaine]

Khat filled the hole. I would place it over dextro-Amphetamine.
But it s been years since i took it so i might review my opinion.
I f i ever get the chance to chew on twig s again. I ll do a update.

Very alike PV and MDPV, only missing the tail on one.
I on Pharmacological research dismiss em.

Bring out the Aminorex, Phencamfamine and Phenmetrazine s !
 
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Never got the chance to try it yet because of scarcity but I'd say that 4-methylaminorex might be a candidate. 4,4'-dimethylaminorex blew me away but that one is an empathogen. Always been curious about Khat. Prolintane I tried briefly before it went out of stock for good, was nice, functional but also euphoric, I'd say it was better than dexamph. Got Vyvanse on prescription in my old country and didn't like it too much. Ritalin is even worse, only good when mixed with a NMDA antagonist.
 
Meth and MDMA combined. Most euphoric thing I've ever experienced. Almost indescribable.

Khat was pretty good for a plant. Prepared properly and in right situation. Socialising or just lying on the sofa sipping a beer. Mixed well with booze n weed. But also great because you could sleep when the night was done.
 
:heart6: Most Cathinones, the first wave was good.
Still wonder about 5-Me-Ethylone 😛. But glad i skipped 4-MMC.
Sounded dangerously good. But Cathinone and Methylone 👍
4-MEC and 3-MMC 👎 Ethylone ☯️ Better then 🍺,
and slightly emphatogenic.

Most i wouldn t mess with Fluor/ Chloro/ Bromide or Iodo analogues.
So hit or miss avoiding those. Success rate 33 %.
To encounter ime world s new classification of drug s.

Sloppy Stimulant s and Emphatogen s,
5-Me-Ehylone aswell 4-MMC sound emphatogenic, no exp.

Prolintane looks after checking more like the Pyro-Valerones.
It sounds as a pretty tolerable substance, exception that confirm s the rule
Well i try it, like Fenethylline despite the mixed reports.

Glorifying to Amphetamine is better. Just want a taste of all of them.
Research purposes

:geek:
 
Out of all stims I tried the ones that produced the most euphoria were probably 3-MMC and the rush of pyros (short lived), amphetamine and methamphetamine were also amazing.

But most euphoria probably the first 2 doses of 3-MMC, most balanced ratio of serotonin to dopamine for me.

Best for sustained euphoria and productivity was amphetamine/meth/lisdex

Most ”fun” to binge was a-PHP, a strange ”primal” satisfaction after every hit unlike anything else.

Altough if I was still in active addiction and had to pick between all of these I would likely go for 3-MMC or regular amphetamine most of the time. Never had the chance to try 4-FA altough I feel like I might have liked that one more than 3-MMC or amphetamine
Think I tried like 25 - 30 stims, I had a good run 😂
 
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