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Miscellaneous Most anxiolytic psychedelic drugs

I think the OP didn't enjoy salvia. Don't forget, YMMV.

It's no secret that salvia increases the activity of dopamine while decreasing the activity of serotonin via the KOR and ERK1/2. KOR ligands are noted for producing dysporia as well, so possibly not a good fit?


I've known a lot of people try it but none of them tried it more than a couple of times. It seems only a minority of people enjoy it's effect OR indeed, that minority just don't suffer the unwanted side-effects.

I think @fastandbulbous tried some other KOR ligands (I presume because they are noted as hallucanations) but his trip reports were along the lines of Heart of Darkness.

I feel LSD is likely to be the best bet. After all, it's the most selective in it's action. It doesn't act on the monoamine transports as far as I know. But with all that class, it's all about set and setting. If you are anxious or unhappy, that can be amplified.

Interesting that psilocin is being trailled for depression. That makes sense as it's a serotonin derivative.

If you want a tryptamine with a HUGE amount of seorotonin releasing activity, the 7-methyl derivative of pretty much any of them will provide it. Sadly, ring-substituted tryptamines are a total pain to produce. We had samples made of 7,a-DMT (7-methyl AMT) and then had the two enantiomers resolved. I would have to check but the (S) enantiomer was trippy at higher doses (but still making the body release that serotonin) while the other was an entactogen.

It really was very good - just too costly.
 
4DQSAR said:
I think the OP didn't enjoy salvia. Don't forget, YMMV.

It's no secret that salvia increases the activity of dopamine while decreasing the activity of serotonin via the KOR and ERK1/2. KOR ligands are noted for producing dysporia as well, so possibly not a good fit?


I've known a lot of people try it but none of them tried it more than a couple of times. It seems only a minority of people enjoy it's effect OR indeed, that minority just don't suffer the unwanted side-effects.

I think @fastandbulbous tried some other KOR ligands (I presume because they are noted as hallucanations) but his trip reports were along the lines of Heart of Darkness.

I feel LSD is likely to be the best bet. After all, it's the most selective in it's action. It doesn't act on the monoamine transports as far as I know. But with all that class, it's all about set and setting. If you are anxious or unhappy, that can be amplified.

Interesting that psilocin is being trailled for depression. That makes sense as it's a serotonin derivative.

If you want a tryptamine with a HUGE amount of seorotonin releasing activity, the 7-methyl derivative of pretty much any of them will provide it. Sadly, ring-substituted tryptamines are a total pain to produce. We had samples made of 7,a-DMT (7-methyl AMT) and then had the two enantiomers resolved. I would have to check but the (S) enantiomer was trippy at higher doses (but still making the body release that serotonin) while the other was an entactogen.

It really was very good - just too costly.
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Any idea why some people seem to experience dysphoria from salvia (and presumably other kappa opioid substances) while others do not? I suppose that's a better topic for another thread though.
 
SotPoker1012 said:
Any idea why some people seem to experience dysphoria from salvia (and presumably other kappa opioid substances) while others do not? I suppose that's a better topic for another thread though.
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In the same way as MOR ligands produce euphoria I assume.

There will always be zebras who don't respond to a drug in the same way the majority of people do. I know someone for whom opioids have no effect whatsoever. They have been given several and non have any discernable effect.

As I said - I know quite a few people who tried it but none tried it twice.

I've noted that there are some people who will seek almost any ASC. I've come across people who BOUGHT antipsychotic drugs. Repeatedly!
 
SotPoker1012 said:
Any idea why some people seem to experience dysphoria from salvia (and presumably other kappa opioid substances) while others do not? I suppose that's a better topic for another thread though.
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Disphoria/ Euphoria on Salvia ?
I was relieved i was still alive when i came back to Earth,
that is not even covering it while in it felt as never-ending.

So i was surprised, that the world i forgot during, existed.
 
4DQSAR said:
In the same way as MOR ligands produce euphoria I assume.

There will always be zebras who don't respond to a drug in the same way the majority of people do. I know someone for whom opioids have no effect whatsoever. They have been given several and non have any discernable effect.

As I said - I know quite a few people who tried it but none tried it twice.

I've noted that there are some people who will seek almost any ASC. I've come across people who BOUGHT antipsychotic drugs. Repeatedly!
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To be fair, those people probably dived into the deep end. Like all drugs, salvia is dose and ROA dependent. Chewing a bit of raw salvia is an entirely different experience than, say, smoking 50x. The availability of those highly concentrated extracts in smoke shops in the mid 2000s, combined with a total lack of education about salvia, probably traumatized a lot of people that would've had a different experience with a different way of consuming salvia.

It's like taking 12 grams of mushrooms on your first psychedelic experience. Most people would find that incredibly upsetting, but those who start at a reasonable dose often enjoy it.
 
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emkee_reinvented said:
Disphoria/ Euphoria on Salvia ?
I was relieved i was still alive when i came back to Earth,
that is not even covering it while in it felt as never-ending.

So i was surprised, that the world i forgot during, existed.
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That's one way to enjoy salvia, for sure, but a better place for most people to start is either a weaker extract or to chew raw salvia. There's a whole spectrum of effects that vary based on dose and ROA.

(Sorry for double posting, I couldn't figure out how to insert quotes into an edit)
 
Most anxiolytic?

Tough question. IME shrooms can be anxiolytic and can also be the opposite - acid too i think. I can't really imagine that any psyche can be guaranteed to be so though

From what I've read Mescaline sounds very easy-going emotionally
 
Well, as I mentioned, psilocin is very similar to serotonin.

We (re)discovered a couple of Upjohn patents from the 1960s and they discovered that aET was a potent antidepressant. But as Shulgin noted, it's effects are so similar to those of MDMA that it was being sold AS Ecstacy and given it's legal status at the time, the vendor got away with a harsh warning by the judge. But it remained legal so guess what? Yep, the guy just carried on selling it and the second judge stated that if there was a third occassion, the vendor WOULD be jailed.

Similarly, AMT was actually used clinically to treat depression in Russia for over a decade. I think the dose was 5-10mg/day.

What Upjohn noted was that the 7 methyl derivatives were an order of magnitude more potent in their serotonin modulating activity but concerned that AMT was known to be a hallucenogen, they only ever tested 7-methyl AET.

But I keep pointing out that all of the alpha substituted tryptamines are chiral. One is a 5HT2a ligand while the other is not. I know this because we had a sample resolved and while the (R) enantiomer was much like ecstacy, the (S) was , well, VERY trippy but without the serotonin modulation lacked the warmth of the raecemate.

But (R) 7,a-DMT (7-methyl AMT) WOULD be cosly Ecstacy alternative it does have two important advantages. It's a LOT more potent and it's legal in most places.

BTW (S) 7,a-DMT is still a very active hallucenogen - my key point being that although you resolve the two - both are highly active.
 
4DQSAR said:
Didn't William S. Burroughs suggest that all pleasure is relief?
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sadly, this is untrue, although pleasure is a compelling distraction, as is beauty, excitement, music...
each drug has a dose response curve that may vary per person but More than 90% of the salvia divinorum sessions in the world are overdosed rather than titrated up from a gentle dose in an intelligent exploration.
Eg. Daniel Siebert recommended 1000ug salvinorin A as a good way to get the full effect.
but, you know that the full effect is blackout or a repeating experience of blackout aka amnesia for 10 minutes mixed with feeling your body enmeshed with everything else in the planet and immense gravitation and confusion.

I would say that the full effect is not a good one, but you can get that also with alcohol or any of a number of other substances done in excess.
My go to dose is 350ug which is about 1/3 the Siebert recommendation - and the full effect of heroin is death, same with many others. Full effect is not what we should be considering something of value to experience. What is the full effect of a jet engine? the good effect is the right amount to let the plane fly safely and comfortably.

Anyway both lsd and salvia are non-lethal at any reasonable dosage and I highly recommend them to anyone exploring, however I never think to say they are anxiolytic or to advise people to seek relief from anxiety in drugs.
 
The pleasure of beauty, the pleasure of music...

Excitement isn't pleasure, it's euphoria.
 
4DQSAR said:
The pleasure of beauty, the pleasure of music...
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The pleasure of beauty would be the relief of ugliness. The pleasure of music, consisting of harmony, and melody, is a relief from disharmonious situations. ;) in certain ways I have always been able to insert examples into that William S Boroughs statement.
 
4DQSAR said:
Didn't William S. Burroughs suggest that all pleasure is relief?
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Explain s my aftermath s on Mushroom s. Feeling bad during.
Time dilation ensuring you can really get a good feel,
of how shitty it makes me feel. During its effect s.

Now jump 5 hour s further as its slowly fading out.
Oh i so glad it over its near Euphoria. Go to bed.
After waking the whole next week is filled with the remain s.
Of that relieve of the ending of Psilocybine s,
direct psychedelic effect s, which would be best described as:
a firm improvement on positive mood.
As if the machine had a revision.

During my trip, so feelings akin to depression, anxiety and such dissipated.
And the good thing s in live where amplified. Happy ending s.
 
pupnik said:
sadly, this is untrue, although pleasure is a compelling distraction, as is beauty, excitement, music...
each drug has a dose response curve that may vary per person but More than 90% of the salvia divinorum sessions in the world are overdosed rather than titrated up from a gentle dose in an intelligent exploration.
Eg. Daniel Siebert recommended 1000ug salvinorin A as a good way to get the full effect.
but, you know that the full effect is blackout or a repeating experience of blackout aka amnesia for 10 minutes mixed with feeling your body enmeshed with everything else in the planet and immense gravitation and confusion.

I would say that the full effect is not a good one, ...
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Nice your description is exactly what Salvorin-A had as effect on me.
And due to the fact it was a new substance for me, and a extract.
Not even a ridiculous strong one, but strong enough my titration,
went wrong. Starting with a few bits of leaf.

A few crumbles/ a half filled one hitter. Was already a overdose.
Same happened to me with the Synthoid s, got a freeby.
Aimed at the UK market, who been toking for years.
So the strength was raised accordingly to UK tolerance.
Which i lacked.

SSDD, half filled one hitter, and it hit like Nuclear bomb.
Embarrassing and unnecessary, as i had the green stuff.
Lucky Sythoid s are not deadly. Just nightmarish like Cannabis.
Real Weed too, it was just a little experiment, that kicked my ass.
 
LucidSDreamr said:
5HT receptors agonists are stimulating mostly and not relaxing feelings .

MDxx in the most sedating psychedelic drug. And not due to its psychedelic properties.

What’s that one mdxx analogue that only releases serotonin and zero dopamine? Maybe this. Is this compound a 5HT agonist?

Is there any actual 5HT agonist like drug that is anxiolytic at all?
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Have used MDMA, MDAI, APBs, and they are all less anxiolytic than aMT, IME.
Have used it in ranges from 5mg to 150mg+, it is anxiolytic from 10mg and up.

aMT is a 5HT agonist, and a very strong releaser of Serotonin and Dopamine, almost as good as methamphetamine, but it is a weak releaser of adrenaline.
 
LucidSDreamr said:
Nbome are probably the least anxiogenic psychedelics I’ve ever tried. That’s a good answer. Feeling sober with just powerful visuals is nice.

All the other ones have some sense of stress to them even though I did tons of them and have always been fascinated with their effects so I was willing to do them all.

Dissociatives are anxiolytic at times but I don’t count them as psychedelics like this sub forum does
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IME I don't have anxiety when using psychedelics, but NBOMes, and in particular 25i, have been some of the most anxiety inducing psychedelics.
In my experience of seeing others take them, that is.
 
the nbox's are all phenethyamine type so - they have stimulant origin and they push harder than lysergamides.
 
pupnik said:
the nbox's are all phenethyamine type so - they have stimulant origin and they push harder than lysergamides.
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From my understanding they are highly selective for 5ht2ar.

Lisergamides are dopamine receptor agonists. That makes them more stimulating. In addition to 5HTR agonists

I think the nbome super high selectivity might have something to do with the lack of anxiety in their experience. Maybe some of these other 5HTR subtypes are what make trips anxious or emotional unlike nbome
 
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