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Miscellaneous Most anxiolytic psychedelic drugs

I think the OP didn't enjoy salvia. Don't forget, YMMV.

It's no secret that salvia increases the activity of dopamine while decreasing the activity of serotonin via the KOR and ERK1/2. KOR ligands are noted for producing dysporia as well, so possibly not a good fit?


I've known a lot of people try it but none of them tried it more than a couple of times. It seems only a minority of people enjoy it's effect OR indeed, that minority just don't suffer the unwanted side-effects.

I think @fastandbulbous tried some other KOR ligands (I presume because they are noted as hallucanations) but his trip reports were along the lines of Heart of Darkness.

I feel LSD is likely to be the best bet. After all, it's the most selective in it's action. It doesn't act on the monoamine transports as far as I know. But with all that class, it's all about set and setting. If you are anxious or unhappy, that can be amplified.

Interesting that psilocin is being trailled for depression. That makes sense as it's a serotonin derivative.

If you want a tryptamine with a HUGE amount of seorotonin releasing activity, the 7-methyl derivative of pretty much any of them will provide it. Sadly, ring-substituted tryptamines are a total pain to produce. We had samples made of 7,a-DMT (7-methyl AMT) and then had the two enantiomers resolved. I would have to check but the (S) enantiomer was trippy at higher doses (but still making the body release that serotonin) while the other was an entactogen.

It really was very good - just too costly.
 
4DQSAR said:
I think the OP didn't enjoy salvia. Don't forget, YMMV.

It's no secret that salvia increases the activity of dopamine while decreasing the activity of serotonin via the KOR and ERK1/2. KOR ligands are noted for producing dysporia as well, so possibly not a good fit?


I've known a lot of people try it but none of them tried it more than a couple of times. It seems only a minority of people enjoy it's effect OR indeed, that minority just don't suffer the unwanted side-effects.

I think @fastandbulbous tried some other KOR ligands (I presume because they are noted as hallucanations) but his trip reports were along the lines of Heart of Darkness.

I feel LSD is likely to be the best bet. After all, it's the most selective in it's action. It doesn't act on the monoamine transports as far as I know. But with all that class, it's all about set and setting. If you are anxious or unhappy, that can be amplified.

Interesting that psilocin is being trailled for depression. That makes sense as it's a serotonin derivative.

If you want a tryptamine with a HUGE amount of seorotonin releasing activity, the 7-methyl derivative of pretty much any of them will provide it. Sadly, ring-substituted tryptamines are a total pain to produce. We had samples made of 7,a-DMT (7-methyl AMT) and then had the two enantiomers resolved. I would have to check but the (S) enantiomer was trippy at higher doses (but still making the body release that serotonin) while the other was an entactogen.

It really was very good - just too costly.
Click to expand...
Any idea why some people seem to experience dysphoria from salvia (and presumably other kappa opioid substances) while others do not? I suppose that's a better topic for another thread though.
 
SotPoker1012 said:
Any idea why some people seem to experience dysphoria from salvia (and presumably other kappa opioid substances) while others do not? I suppose that's a better topic for another thread though.
Click to expand...

In the same way as MOR ligands produce euphoria I assume.

There will always be zebras who don't respond to a drug in the same way the majority of people do. I know someone for whom opioids have no effect whatsoever. They have been given several and non have any discernable effect.

As I said - I know quite a few people who tried it but none tried it twice.

I've noted that there are some people who will seek almost any ASC. I've come across people who BOUGHT antipsychotic drugs. Repeatedly!
 
SotPoker1012 said:
Any idea why some people seem to experience dysphoria from salvia (and presumably other kappa opioid substances) while others do not? I suppose that's a better topic for another thread though.
Click to expand...
Disphoria/ Euphoria on Salvia ?
I was relieved i was still alive when i came back to Earth,
that is not even covering it while in it felt as never-ending.

So i was surprised, that the world i forgot during, existed.
 
4DQSAR said:
In the same way as MOR ligands produce euphoria I assume.

There will always be zebras who don't respond to a drug in the same way the majority of people do. I know someone for whom opioids have no effect whatsoever. They have been given several and non have any discernable effect.

As I said - I know quite a few people who tried it but none tried it twice.

I've noted that there are some people who will seek almost any ASC. I've come across people who BOUGHT antipsychotic drugs. Repeatedly!
Click to expand...
To be fair, those people probably dived into the deep end. Like all drugs, salvia is dose and ROA dependent. Chewing a bit of raw salvia is an entirely different experience than, say, smoking 50x. The availability of those highly concentrated extracts in smoke shops in the mid 2000s, combined with a total lack of education about salvia, probably traumatized a lot of people that would've had a different experience with a different way of consuming salvia.

It's like taking 12 grams of mushrooms on your first psychedelic experience. Most people would find that incredibly upsetting, but those who start at a reasonable dose often enjoy it.
 
Last edited:
emkee_reinvented said:
Disphoria/ Euphoria on Salvia ?
I was relieved i was still alive when i came back to Earth,
that is not even covering it while in it felt as never-ending.

So i was surprised, that the world i forgot during, existed.
Click to expand...
That's one way to enjoy salvia, for sure, but a better place for most people to start is either a weaker extract or to chew raw salvia. There's a whole spectrum of effects that vary based on dose and ROA.

(Sorry for double posting, I couldn't figure out how to insert quotes into an edit)
 
Most anxiolytic?

Tough question. IME shrooms can be anxiolytic and can also be the opposite - acid too i think. I can't really imagine that any psyche can be guaranteed to be so though

From what I've read Mescaline sounds very easy-going emotionally
 
Well, as I mentioned, psilocin is very similar to serotonin.

We (re)discovered a couple of Upjohn patents from the 1960s and they discovered that aET was a potent antidepressant. But as Shulgin noted, it's effects are so similar to those of MDMA that it was being sold AS Ecstacy and given it's legal status at the time, the vendor got away with a harsh warning by the judge. But it remained legal so guess what? Yep, the guy just carried on selling it and the second judge stated that if there was a third occassion, the vendor WOULD be jailed.

Similarly, AMT was actually used clinically to treat depression in Russia for over a decade. I think the dose was 5-10mg/day.

What Upjohn noted was that the 7 methyl derivatives were an order of magnitude more potent in their serotonin modulating activity but concerned that AMT was known to be a hallucenogen, they only ever tested 7-methyl AET.

But I keep pointing out that all of the alpha substituted tryptamines are chiral. One is a 5HT2a ligand while the other is not. I know this because we had a sample resolved and while the (R) enantiomer was much like ecstacy, the (S) was , well, VERY trippy but without the serotonin modulation lacked the warmth of the raecemate.

But (R) 7,a-DMT (7-methyl AMT) WOULD be cosly Ecstacy alternative it does have two important advantages. It's a LOT more potent and it's legal in most places.

BTW (S) 7,a-DMT is still a very active hallucenogen - my key point being that although you resolve the two - both are highly active.
 
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