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Opioids Morphine -oral or nasal?

D

Drew.

Bluelighter
Joined
Jan 19, 2012
Messages
162
Recently I've acquired 15 mg pills of morphine. Personally I have tried oxycodone (10 mg) and codeine (200 mg). I have read online about how taking morphine orally will cause it to lose potency through the process. I have heard nasal ingestion counters this problem. I hate drip, but I heard it's worth it. Any tips on the differences and if it's even worth sticking up your nose? Especially if you can get a good pain relief off these ?
 
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the reason the oral/nasal BA of morphine, compared to IV, is that it has to go through first pass metabolism, losing a fair amount of the drug through the process.

there's little difference overall in the BA of nasal and oral morphine but most anecdotal evidence concludes nasal to be almost usless; you'll be best off taking it orally imo. it provides a lot more euphoria overall imo.

your other option is plugging it which may or may not, depending on you, increase the effects. it also does for myself.
 
That is actually what I want to try in five days...
I successfully took one orally with no nausea. However I was definitely feeling slight euphoria and was extremely comfortable.
My next time, I plan to try and plug it, which I'll have to look up to properly do.
If I was okay with one pill orally, do you think I'd be safe with two and a half?
And if I was plugging it would it be too much for my tolerance?
 
I really doubt that nasal administration is any more effective than oral dosing. From experience, nasal morphine is an extreme waste.

With morphine I am exclusive to the rectal ROA (probably for a good reason, right? ;) ) with oral coming in close 2nd.
With rectal I have extremely fast onset, definitely faster than nasal, and a MUCH longer duration, on par with a time released oral dose. Despite having a 2 hour half life, when I dosed 50mg rectally, I still felt effects after 12 hours! That's unheard of for me through other ROAs.

http://www.bluelight.ru/vb/threads/616156-How-To-prepare-liquid-Morphine-from-time-released-tablets
 
I take your word Tri. I haven't had them in quite some time so I'd orally dose morph's these days. The drip is awful, much worse than most heroin.
 
^Yeah, there are some drugs I can understand why people put up their noses, morphine from tablets ain't one of them, let alone a 5mg tablet! I haven't even heard of a dose that low for oral morphine tablets, I would imagine the pill contains a HUGE inactive ingredient to active ingredient ratio, making it probably the worst form of morphine you could put up your nose. Even if you had pure morphine powder, it would still be very inefficient.
 
It's actually been looked into and they are 15 mg blue pills. I edited my post earlier on my mobile device but... ?

Thanks for all the tips, guys! If I were to ever to share some with a friend, it would be completely awkward to plug.. together! Imagine. ;)

If I were to take another half-pill a couple of hours after taking my one (or two) pill(s) orally, would it be a complete waste of the morphine, just like codeine?
 
^Gotcha, that makes sense, they don't even make 5mg morphine tablets in the US, at least, not that I'm aware of.

And no, redosing isn't a waste like codeine.
 
I have now (a few days ago) taken up to two of these pills within an hour, orally. I wasn't sick at all, but tomorrow I am going to
try three. All at once. The only concern I have at this point is pushing it too far and getting sick, which I definitely wouldn't want to happen.For someone like myself who has tried it twice in the past week, I should have a weak tolerance for it, correct? If any?
In which case, would someone who has done the same amounts of oxycodone and codeine get the same tolerance effect IF the person hadn't participated in opiate use in a while? Say, months?
 
If you've taken it twice this week, well three times including now, you certainly have a tolerance. By no means is it substantial, but you will definitely be able to feel how your tolerance has grown. I'd say you have a low tolerance for the doses you've been taking. 15-30mg over 12 hours which is realllllly not that much. 30mg Morphine ER comes out to 2.5mg/hour which is not much at all.

With every dose you take, you will notice the effect of tolerance more and more. Tomorrow when you take 45mg ER, you'll get 3.75mg/hour.

That being said, you should be careful because after you take the 45mg, it probably won't feel very strong right away, but it will keep building on itself every hour, so don't take a fourth pill and go to 60mg, because 5mg/hour is a substantial increase from what you're used to.

Tolerance to opioids builds extremely quick, and takes a loooooooong time to go down. I would say more than months. Going months without and then dosing will certainly be much stronger than it would taking it daily, but by no means will it ever feel like the first times you did opioids.
 
Let's say you get the maximum oral BA 30%, and let's say rectal bumps you up to 60%, so half your dose is about right. The onset should be very rapid and will continue to increase reaching peak serum levels after about 30 mins to an hour IIRC.
 
From 3p.m. yesterday till 12 a.m . I managed to orally dose 45 mg, starting with 25 mg and occasional redosing till I eventually got a nod (never happened before, I'd close my eyes without even knowing at times, or stare off, etc..).
Next time I'll probably try plugging route, just to see the difference.
 
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