Moderate Drinking Decreases Number of New Brain Cells

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http://www.sciencedaily.com/releases/2012/10/121024164759.htm

Drinking a couple of glasses of wine each day has generally been considered a good way to promote cardiovascular and brain health. But a new Rutgers University study indicates that there is a fine line between moderate and binge drinking -- a risky behavior that can decrease the making of adult brain cells by as much as 40 percent.

In a study posted online and scheduled to be published in the journal Neuroscience on November 8, lead author Megan Anderson, a graduate student working with Tracey J. Shors, Professor II in Behavioral and Systems Neuroscience in the Department of Psychology, reported that moderate to binge drinking -- drinking less during the week and more on the weekends -- significantly reduces the structural integrity of the adult brain.

"Moderate drinking can become binge drinking without the person realizing it," said Anderson."In the short term there may not be any noticeable motor skills or overall functioning problems, but in the long term this type of behavior could have an adverse effect on learning and memory."

Shors and Anderson worked with postdoctoral fellow Miriam Nokia from the University of Jyvaskyla in Finland to model moderate to heavy drinking in humans using rodents that reached a blood alcohol level of 0.08 percent -- the legal driving limit in the United States and many other countries -- and found that brain cell production was affected negatively.

The researchers discovered that at this level of intoxication in rats -- comparable to about 3-4 drinks for women and five drinks for men -- the number of nerve cells in the hippocampus of the brain were reduced by nearly 40 percent compared to those in the abstinent group of rodents. The hippocampus is a part of the brain where the new neurons are made and is also known to be necessary for some types of new learning.

This level of alcohol intake was not enough to impair the motor skills of either male or female rats or prevent them from associative learning in the short-term. Still, Anderson said, this substantial decrease in brain cell numbers over time could have profound effects on the structural plasticity of the adult brain because these new cells communicate with other neurons to regulate brain health.

"If this area of your brain was affected every day over many months and years, eventually you might not be able to learn how to get somewhere new or to learn something new about your life," said Anderson, a graduate fellow in the Department of Neuroscience and Cell Biology. "It's something that you might not even be aware is occurring."

http://www.sciencedaily.com/releases/2012/10/121024164759.htm
 
Is 5 drinks (for a man) a night considered "moderate drinking"?
Seems very heavy to me, if it is an average.
The title of the article refers to moderate drinking, but then the article talks about binge drinking.
The study on rats is supposed to be the equivalent of 5 drinks (for a man, 3-4 for a woman).
Maybe if someone does that once in a while, it is "moderate drinking"?
I don't know about anyone else, but if I don't drink anything for a few weeks or months (which often is that case), and then I drink one night, even 3 drinks in a few hours will have me quite drunk. I would not feel like 5 drinks was moderate.
If I drank 3 drinks a night for a while, and got used to it, 5 might seem moderate, but then my weekly total would be more than 21 drinks, which is pretty damn heavy.

Personally, I try to stay away from alcohol most of the time.
I love the taste of dark beer and good red wine, but I hate neurotoxins. :p
 
I was under the impression that five was the standard "binge" minimum for women, and over that was considered a "binge" for men

nevertheless I doubt many would consider five a "moderate" amount for anyone
 
5 drinks would be a moderate night for a large number of male drinkers in college. Not me but my room mate can pound away 12 and that's a big night for him.
 
5 drinks is nothing. No wonder I'm so fucking dumb. Sometimes I enjoy being stupid and ignorance can be bliss.
 
I don't see the frequency which the rats were intoxicated at 0.08% level intoxication. Something about the way this is presented suggests to me that they were keeping the rats at this level of intoxication for some period.
 
borrachos.jpg


It's true, rats cannot handle their alcohol!
 
5 drinks is nothing. No wonder I'm so fucking dumb. Sometimes I enjoy being stupid and ignorance can be bliss.

i agree- i can neck 7 pints maybe more on a night out, and i am also aware of korsakoffs syndrome and the fact the brain is made of fat and lipids and that both of these are soluble in alcohol. yet still i damage myself for a cheap high, if only my awareness translated into a change in behaviour yet the only thing i care about in relation to alcohol consumption is the state of the skin on my face/my liver and my heart. the brain takes a step back for some reason.

i just really like drinking and i've tried a lot of other drugs in large amounts over long periods of time. cannabis in hash form being the other thing i like regular.
i smoked my own home made opium but i find my favourite drugs all affect serotonin- cocaine/mephedrone/mdma/mescaline/alcohol/3-meo-pcp, tramadol, i see a pattern forming. obviously mescaline is a bit different bit its a goodie that i dont rush into
 
Guess it's time to try some different drugs. I've been mixing caffeine pills (200mg) and moderate drinking (4-5 drinks) for the past few months, which has been fun. I get the same positive push towards higher sociability that I used to with heavy drinking (8-9 drinks) plus a slight decrease in social inhibition, but without a lot of the stupidity and recklessness I would get with heavy drinking. Looks like this level moderate drinking might have more negative effects than I imagined though.. :/

I wonder what other drugs lower inhibitions as well as alcohol, won't kill my brain, and aren't hopelessly addictive. Because I highly doubt I'll be satisfied binging caffeine while my friends are all getting drunk.
 
hmm 5 drinks ... i still find this to be a hard thing to gauge i mean seriously a lot of people can be somewhat functional after 5 beers but after 5 shots of whiskey most people are much more on the shitfaced side of the spectrum
 
hmm 5 drinks ... i still find this to be a hard thing to gauge i mean seriously a lot of people can be somewhat functional after 5 beers but after 5 shots of whiskey most people are much more on the shitfaced side of the spectrum

A 'standard drink' is a measurement for a certain amount of alcohol. I don't know how much it is because in the UK we measure it in "units" of alcohol which are 10ml each.
 
Who would have thought a cytotoxic substance like ethanol would decrease cellular proliferation...

I dislike how the title says 'moderate drinking' and then goes on throughout the article to include statements like 'moderate to binge drinking', and that 'moderate drinking can become binge drinking without the person realizing it'. Moreover, I'm pretty sure 3-4 drinks for women, or 5 drinks for men is not typically considered 'moderate drinking'. It would be nice if the journalists that publish this kind of stuff would use less ambiguous, and more scientifically accurate language.

(Lol, just read slimvictor's post after I wrote this, and I agree :D)
 
Insofar as it goes, this finding is interesting, and warrants further research. But what is worrying is how it is reported, in particular the way the findings are extrapolated to everyday drinking without any critical thought.

What the study has shown is that a certain amount of alcohol will reduce the rate of neurons in the hippocampus in rats.

But:

1) Rats aren't the same as humans.

2) It sounds like the measurements were taken during acute intoxication, which represents a small proportion of total lifetime for all but the most problematic drinkers.

3) The causal pathway between hippocampal cell depletion and subsequent health problems has not been demonstrated by the study. The researchers admit this, saying "This level of alcohol intake was not enough to impair the motor skills of either male or female rats or prevent them from associative learning in the short-term." In other words, no effect on well-being was observed, but a potential long-term association was nevertheless inferred, because "If this area of your brain was affected every day over many months and years, eventually you might not be able to learn how to get somewhere new or to learn something new about your life...It's something that you might not even be aware is occurring." Note the repeated use of the word "might" - this seems to be largely based on conjecture rather than evidence. This study cannot tell us the clinical significance of "the number of nerve cells in the hippocampus of the brain...[being]... reduced by nearly 40 percent compared to those in the abstinent group of rodents". How are we to know what this means in terms of our health? This difference in hippocampus activity may take longer than a lifetime to manifest itself in terms of cognition, if indeed it is harmful at all.
 
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