no, you'd run a pretty high risk of possibly fatal CNS/respiratory depression. It depends on the doses of course, and your tolerance to each drug, gabapentin, alprazolam, and hydrocodone/APAP.
Thank you everyone. I took a milligram of xanax and my Norco(wich I've been on 30 mg a day for 5 years) and skipped my gabapentin last night. I was fine relaxed and out cold 5 mins after they kicked in. so about 45 mins after I took them. I don't normally do that but was over whelmed too much last night and needed the xanax to stop my brain from over compulsing (note: I also skipped my celexa)
If you must mix 2 out of 3 of these drugs then mix the gabapentin and hydrocodone. Don't mix the alprazolam and hydrocodone and most certainly don't mix all 3 as gabapentin will potentiate the alprazolam.
Define safe. Google a drug interaction calculator I've mixed all of those for medical reasons before no problem. Its all about dosage and experience with this combo. If your not real familiar with these medicines then I wouldn't do this.