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Mirtazapine comments!

I've been on mirtazapine for about a year now (after being on various SSRI's for the previous 2 years).

Mirtazapine kicks ass as far as I'm concerned: taken at night (the only time i take it) it promotes sleep and sustains it as far as i'm concerned.

15mg is my dose but if i pop 3 or 4 ....BAM! Lights (gently out) and a full 12 hours.

Incidentally, I ran out a week ago and have barely slept a fucking wink without it.

Oh yeah, and once i was stable on it the mad urge to eat everything subsided (give it a couple of weeks). AND it works well as an anti-depressant.

Mr Moss, I heartily recommend this drug to you.
 
MrMoss said:
2. Does it promote sleep or simply lead to longevity? I have problems getting off to sleep but not remaining asleep as a rule.

In my experience it did both. Like you, my main problem is falling asleep and mirtazapine really helped with that.

I found it made me very groggy for the first few days, but after that I had no problems getting up in the morning (maybe a little groggier than usual in the first few minutes after getting up but it went away pretty quickly). It was easy to sleep for 10+ hours when on it - I had to buy an alarm clock for the first time ever, otherwise I'd just keep sleeping!

I had no sexual side effects from it at all. In fact, the only side effect I got was the weight gain, which was around 10 kilos. It does increase your appetite, but I'm certain it must have some effect on metabolism as well as I was eating much more healthily than usual (and running around 20k a week) and I still put on weight.

Everyone reacts to medications differently, obviously, but mirtazapine worked really well for me. I've never slept so well before in my life. :)
 
Working full time so wrote my Doc a letter saying I want scripted this and he contact me with a Yes or No or an appointment to discuss if this is suitable for me. I assume he'll agree as it matches my profile ... we'll see I guess.

Thanks for the replies folks appreciated :)
 
Only thing remeron did for me was knock me out and made me gain 30 pounds in the 6 months I was taking it. I stopped taking it and switched to Cymbalta.
 
^ Too late I'm taking the plunge ... I tried Effexor an SNRI no thanks ... this stuff pharmacologically speaking sounds the panacea but I'm not that naive

Duloxetine is a selective SNRI (selective serotonin-norepinephrine reuptake inhibitor).

Cheers though :)
 
Remeron (mirtazapine) sucks.. really bad.. worst anti depressant i've ever taken and i've tried alot of them. all you want to do is eat and sleep. i could NEVER get enough sleep and i felt like a zombie even if i got 10+ hours of sleep, and you will gain shitloads of weight. do a search for it on these boards and you'll see tons of other people with the same experience as me. if you just want to try it because you can roll when your on it, its not worth it believe me.
 
I found mirtazapine to work great. One of the best anti-depressants ive ever tried by far. It's a great mood lifter probably the best as far as anti-depressants go, It usually works within 2 weeks (i could feel it's effect's in about a week or so), is one of the best sleep aids ive ever tried, and it gives you the munchies.

I liked the drowsiness and munchies because i tend to get insomnia really bad sometimes and when i get really depressed i cant eat. So it's side effect profile actually worked for me. It also gave me no sexual dysfunction at all which is a big plus and i had no withdrawal symptoms coming off it even though i gave it up cold turkey.

So i would say definitely give it a try. It sucked less then any anti-depressant ive tried but thats just me. Everybody reacts differently to different drugs.
 
absent minded said:
If you just want to try it because you can roll when your on it, its not worth it believe me.

I've had MDMA once in the last 6 months so a non issue for me. I've been working some hard labour for 4 days now and averaging 3-4 hrs sleep a night when I should be out like a light so the drowsiness from this Med I can only see as a big plus ATM.

paranoid android said:
So i would say definitely give it a try. It sucked less then any anti-depressant ive tried but thats just me. Everybody reacts differently to different drugs.

That's what I'm hoping for :) The side effect profile seems a little too good to be true but I'll suck 'em an see :\

Thanks again folks.
 
MrMoss said:
Two final questions ...
1. How severe is the sexual disfunction? Note: SSRI's were worse than MDMA in that respect (again except Prozac).
2. Does it promote sleep or simply lead to longevity? I have problems getting off to sleep but not remaining asleep as a rule.

1. i dont recall any sexual dysfunction
2. it both promoted and lengthened sleep

one positive effect of mirtazapine was its effect on histamine receptors, for the first time in my life i could play with my dog without having an allergic reaction.

it sounds like your already sold MrMoss. shit, i was too after reading all the literature available on the drug. my experience with the drug however was definetly not as good as the hype i caught myself up in when reading up on it.

but yeh, give it a shot, it could be exactly what your after man ;)
 
been on it three months n didn't really do much appart from weight gain, now been on bupe two weeks and completely turned my life around (no more depression).... i'm still on mirtazepine but sorta wondering why... but it definately hasn't done any (noticeable) harm....
the few side-effects and no W/D's make it an antidepressant well worth a shot at...
 
I used to take mirtazipine before my doctor took me off of it in place of another medication. I put on about 25lbs and did nothing but eat and sleep all day. There are other anti-depressants that work much better than Mirtazipine in my opinion. :|
 
yeah ive been on it for a while, i'm trying to switch to a benzo for my anxiety, the weight gain was a little much for me, but i get the most vivid and lucid dreams ive ever had in my life.
 
I have adhd and Anxiety disorder NOS according to my psychiatrist. I've been on Lexapro, Zoloft, Paxil, Geodon...to no avail. I was put on Geodon to help with anxiety/paranoia in the past but if the feeling of Remeron induced sleep is anything like the zombified, coma-like effects of Geodon, I don't want to touch it. I normally wake up 3-4 times a night for no reason. I'm on Strattera and Concerta now, but the doc said she might switch me to Remeron if the Strattera doesn't show any improvement in me by next month.

So my question is, how powerful is the sleep induced by Remeron? Anything similar to what I experienced on Geodon? (I'd wake up and feel very dream like, very out of it, not at all enjoyable). I work early mornings, and don't want to sleep in and miss work. I am also very anti antihistamine because ever since a bad trip on antihistamines (don't do that anymore), whenever I take an antihistamine, I get heart palpitations and chest pain, anxiety...would Remeron have similar effects? I know I could benefit from the antiemetic properties because I am constantly nauseous alot...but I duno if that benefit would outweigh the negatives.
 
zombiesarepeaceful said:
So my question is, how powerful is the sleep induced by Remeron? Anything similar to what I experienced on Geodon? (I'd wake up and feel very dream like, very out of it, not at all enjoyable). I work early mornings, and don't want to sleep in and miss work. I am also very anti antihistamine because ever since a bad trip on antihistamines (don't do that anymore), whenever I take an antihistamine, I get heart palpitations and chest pain, anxiety...would Remeron have similar effects? I know I could benefit from the antiemetic properties because I am constantly nauseous alot...but I duno if that benefit would outweigh the negatives.

The first time I took mirtazapine, it knocked me the fuck out, easily surpassing all the anti-insomniac agents I've before, which is quite a lot. I found it more far effective than the usual approach for hypnotics: melatonin, ramelteon, quietiapine, and all the 'Z-drugs'...which seem to not affect me in any way other than causing amnesia (zopiclone, zolpidem, zaleplon, etc.) --combined. If insomia is a major problem, I'd say it even edges temazepam to a slight extent! (what I take to this day). Yes, there will be a more than slight hangover, but for me it wasn't too bad. That being said, I slept for 12+ hours every night I took it (30mg dosage)... like a log (you can bury the Geodon similarity worries). I would give in advance more than sufficient time for sleep if you have an early morning schedule, as it tends to induce a heavy slumber in most people.

Since extreme drowsiness is inevitable, and you say you are very anti-antihistamine, if that's the case, then likely this isn't for you. Antihistamine reactions play very major part of its side/effects. But remember they are all not the same.

Remeron is probably the most effective anti-d I've ever been prescribed. Therapeutically, it works wonders and can manage a case of major depressive disorder, like all the others claim they should, but don't. Now it's the side-effects people talk about a lot, and for good reason. I personally got off of it because of the heavy weight gain (and I wasn't eating much more than normal), 35 lbs in about one month! Now I dunno about you, but to me, self-image is pretty important to me and my self-esteem, and it felt it was rather pointless to have a medication that affected it in such a such a negative manner, which would in turn, probably worsen my depression (if it was just a few pounds I wouldn't have cared, but that growth was just too much for me, unfortunately :(). That's why I ultimately got off it after less than a month and a half, somewhat painfully though, because it was so effective at keeping rather severe depression at bay consistently.

That was my case, and my body, you may have a different reaction. In the end, you have to see for yourself if the benefits outweigh the negative side-effects (like all other meds, really). If you are in the deepest pits of hell, I say give it a try. Depression-management wise I've yet to see it's equal, most doctors I've talked to tended to agree. If the S-Es are just too much for you (which from what you say, more than probably are), then just move on. BTW, I lost those pounds rapidly after ceasing intake.

How I wish such a medication existed with equal or superior therapeutic potential for depression, but without the nasty side effects (most of which are antihistaminic). Oh well...maybe someday. :!

Hope you get some beneficial info from this post. :)
 
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I get some mild visuals with mirtazapine, I think this is normal side-effect? Not that I don't like the strange visuals, they are pretty interesting actually. Like doors look distorted or they melt on the top and other funny things. Well I fall asleep pretty quick, so can't really enjoy them long enough. But this is very good for sleeping.
 
Mirtazipine

:)I been on it for about 6 years .
Been on 45mgs for this past 3 years.
I am not so sure it does much for everyday anxiety but can be useful for 'parachuting' out of a drug-induced panic attack.
It certainly helps with sleep - one doesnt seem to be able to build up the same tolerance as can happen with benzo hypnotics. First time taking it , I was out like a light :)

So all things considered, ime i would say it is a good drug for me :D
 
Just started on this.

Have to admit sceptical, but have slept better and generally felt better since I started. Taking approx 20mg at night.


Have not changed anything else big about my life still take some
wine & Mj


Hope it is going to work :)
 
I'm updating this post here as I've discontinued use of Mirtazipine and do not plan on taking antidepressants again.
I don't think they really work. In my opinion (now) an altered stated of consciousness elicited through various AD's probably just merely distracts someone from their depressive state for a while, replacing the mental state with another state equally- if not more- incapacitating. AD's are engineered to be different to serotonin, norepinephrine etc and as such don't belong in the body. It's been stated to me that "you can't drug your body into good health," which makes a lot of sense.
Their effects are poorly understood and their development is really a haphazard science. There are just so many different types and variations (many of which I've tried) and the science should be collapsing upon a locality of success and understanding as apposed to spreading out off into various dichotomous tangents. It doesn't sound like progress, more like a Pandora's box of confusion.'
Ive come across various contentions in my study of AD's- the scariest of which indicates neuro-toxicity.
A relevant study on AD's is : The Emperors New Drugs (subtitled: Exploding The Antidepressant Myth) - I think that's the subtitle anyway. Irving Kirsch is its author. A 'coast to coast' radio interview regarding this is posted up on You Tube.
One other thing also brought out in said studies is that apparently SSRI's have a so-called inert filler or 'binding' substance which combines with the SSRI to produce PCP (or a PCP-like?) once enacted upon by one (or some of) the body's resident enzymes in metabolism (of the aforementioned). [Something to that effect anyway- I wish I could be exact on that, but I have to go through all the information in order to find that particular issue. I believe it's mentioned in the interview]

I felt it a responsibility to edit this post with what I believe to be relevant to it. The following is the earlier post. Of course, my understanding of the facts and opinions have been modified by experience, information and time. Nonetheless the following is hereon unedited and should just be considered a static snap-shot of what I knew back then and nothing more

...

Anyway, one of the first things I should mention is that Mirtazapine can really stimulate eating and cause you to put on weight!
Apart from that, I find that its ability to work also as a 'sleeping pill'- so to speak- is one of its best 'features' for lack of a better term... Normally, my sleeping pattern is muddled and having started college now, sleep is important. An hour after an evening dose it is VERY difficult to fight the pronounced somnolence visited upon you and you must succumb to sleep.
This I find most beneficial despite some intermittent day-time drowsiness.
I've probably tried most of the SSRIs, one tetracyclic and the 'new' Effexor and now find Mirtazapine is the one I'm sticking with.
'Have also in past years 'needed' Valium but not anymore!
Please get back to me/ feel free to ask more of me and take care :)
 
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Mirtazapine sounds very promising. I especially like the fact it's devoid of notorious side effects common with SSRI's etc and the positive side effects in the second quote below :)

I'd like some input from those that have actually used this medication. Please is you have not used this medication don't add to the thread. Many Thanks

watch out, or, just like me, who dared to start a thread about the newly released Pristiq...you will have that modd move your thread to the backwaters of BDD forum...

but i guess that modd is asleep now or crying in his pillow, because you've so many responses.


MY EXPERIENCE WITH MIRTAZAPINE

I think it's old hat. It came out, all the psychiatrists went wild, everyone was put on Remeron, they themselves were put on Remeron. But it's actually not a very safe AD, apart from the incidence of weight gain, which is very high....there's also a suicide rate which follows it around in an annoying gray hood and cape. Not to imply its a suicide pill...but as far as ADs go, Remeron is not high on that list of ADs Associated with Least Fatalities etc. Read the pharm assessment on it....it's surprising what you'll find.

Also, as an AD, it simply doesn't quite make it....it's a shoddy AD. Doctors love it for a substitute for a normal sleeping pill. It's good if you're anorexic and have no job.

My personal testimony - took it for sleep. Went up to 45 eventually, psych says 'now you will see its anxiolytic effect' and i smiled so that he would think i actually believe him or think of him as a person....anyway months later, my anxiety is high as a new york psychiatrist at 3PM, i am eating like 4 horses merged into 4 bigger such horse-merges and i'm depressed at the fact that i'm so tired i can;t do anything and i don't know what to attribute the fat laziness to...the 'hidden depression which has now sprung out' as mr. psychiatrist said, foaming at the mouth...or 'the fucking mirtazapine'.

Needless to say my friend took me to the lounge, we had champ, he said i'll die a loser if i go on. I stopped Remeron, went on Desoxyn and in a month I was a very....VERY sexy, happy, and proud man again.

So to remeron. We will remerember you.
 
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