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  • EADD Moderators: Pissed_and_messed | Shinji Ikari

Methylone vs. Mephedrone Megathread

Don't think serotonin syndrome is a major risk from what I've read - M1/meph work more on the dopamine side of things I think - but am most assuredly no expert.

ingo_2001 said:
phenethylamines (2c'S, MDMA, IAP, METHYLONE, etc.)and most tryptamines (5-MEO'S, 4-aco'S, etc) are fine with SSRI's, the effects are slightly reduced and depends how selective the SSRI is your on Lexapro is the mose selective and the least likely to reduce the effects. However all SSRI's cause you a general tolerance as they cause your receptors to down-grade.

WHAT EVER YOU DO DO NOT TAKE MAOI'S (HARMALINE)

5-MEO-AMT and AMT have slight MAOI effects due to the alpha methyl and I would avoid or start with a very low dose!!!

btw I don't think any of the meds you have listed are true SSRI's I'm sure wellbrutin is a selective adrenaline re-uptake inhibtor as well... Why are you on three meds as well? I don't know what Topomax is. Maybe you shouldn't be doing any more drugs than already prescribed??!!
Click to expand...

The Big and Dandy Medication/Supplement Interaction Thread may be worth having a read through and a good place to ask specific questions.
 
I think methylone works very similarly to MDMA, so mainly serotonin, with a load of dopamine chucked in. It certainly has a huge serotonin component to it. I don't think combining SSRIs with either would be dangerous, however. Just start your doses low.
 
Was reading about this the other night and - if memory serves - the big difference between MDMA and M1 is that whilst both flood your brain with serotonin sexiness, MDMA keeps it in circulation for a while - hence longer duration and lack of fiending. M1 just shoots its serotonin wad but lets it run straight down the plughole leaving you with a heap of dopamine rebound stuff to play with instead - hence short duration and mucho fiending despite redosing being pointles.
 
Yes, MDMA has SSRI properties, hence the afterglow. I've never had such an afterglow from methylone.
 
All times are approximate but not far off.

7pm - 250mg methylone
9pm - 250mg methylone
11pm - 30mg 2C-D
midnight - 250mg mephedrone
2am - 250mg mephedrone
4am - 10mg MDPV
9.00pm - 10mg valium, sleep.

Result = everybody's free to feel good.

Heart issues, none. I really do believe that the question of dodgy heart rates is overblown. Mephedrone works, its a proper drug unlike the crap sold on the streets for the last few years, and proper drugs raise your heart rate. You are meant to feel like that.

I posted this because I had a brilliant night on that combination and I want people to know that in those dosages there should be no issues about lack of safety. I do believe that once you start to go above 500mg with mephedrone you are asking for added side-effects you don't want.
 
How did the 2C-D combine with the methylone and mephedrone? You must have been coming down from your second methylone dose at that stage, did you find it brought you back up? Many visuals/head fuck?
 
Tryptamite said:
How did the 2C-D combine with the methylone and mephedrone? You must have been coming down from your second methylone dose at that stage, did you find it brought you back up? Many visuals/head fuck?
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Many pleasant visuals, no head-fuck, best fuck in the world.
 
Yeah, sounds like a wild ride mr monday, although is that 9pm meant to be 9am? If not, well... that's one eventful day!

Enjoy mephedrone though you, or others may, the chest stuff that some (including myself) have felt is far more than a fast heart, and it's certainly not something one is "meant" to feel at 19 years old after a night out (after taking less than 1/2 a gram of meph, and drinking). Like you say though, mephedrone "works", however that doesn't make it risk free, and for me the risks are clearly not worth it. Glad you had sparkly fun though...

I've stuck with methylone, which is great stuff, but it does make me crash quite hard, and gives toxic-tingles down the spine haha :o
 
^ snorting methylone is a waste of time, it's best taken orally dissolved in a little bit of water IME.
 
Some opiates might help with that :D

I generally find it hard to tell whether 5htp is helping me recover faster or not, I always used to take it after MDMA just in case. If you feel it does help you after MDMA then you might as well take some for a couple of days.
 
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