Methylone + SNRI question

[optimuswind]

The The Big & Dandy bk-MDMA (Methylone) Thread seems to be closed and I can't find a continuation of it after searching and there's nothing in the last post.

Anyway, I currently am on 225mg generic Venlafaxine (Effexor) for depression and social anxiety, I was wondering if anyone knows whether or not I will kill myself via serotonin syndrome if I take Methylone (small doses at a time, 25-50mg probably, once or twice a day for a few days over the course of a few weeks in order to help me get through something). I take serotonin syndrome really seriously because from what I've read if you get it, you're a dead man walking and there's pretty much nothing they can do to help you and _you are_ going to die.

There's no way I'd take MDMA on this, but wikipedia has this to say about Methylone:

Methylone acts as a mixed reuptake inhibitor/releasing agent of serotonin, norepinephrine, and dopamine. In comparison to MDMA, it has approximately 3x lower affinity for the serotonin transporter, while its affinity for the norepinephrine and dopamine transporters is similar.

Now firstly what confuses me is that it says it's a re-uptake inhibitor aswell as a releasing agent of serotonen, does that mean the same thing, that my brain will be flooded with serotonin, and as it's a re-uptake inhibitor, that serotonin is going to stay there longer?

Now my main question is how does this combine with the SNRI I am on which already inhibits the re-uptake and presumably has already increased the amount of serotonin in my brain?

Then it also says it has 3x lower affinity for the serotonin transporter compared to MDMA, I've taken 50-100mg Methylone in the past while on no medication, and while it was definitely not like an MDMA roll, I did feel warm, talkative and sociable, and that's really what i'm looking for.

Anyway I was hoping someone with actual knowledge on how the brain works with regards to these neurotransmitters could say whether or not there is a big risk of serotonin syndrome, could I take a very small amount (10mg?), see what happens and go from there? Would that be a safe route, or could even the effects from 10mg trigger full blown serotonin syndrome death?

Thanks in advance and I hope this is in the right area, if not could a mod move it please?

Thanks again.

 

[sekio]

I take serotonin syndrome really seriously because from what I've read if you get it, you're a dead man walking and there's pretty much nothing they can do to help you and _you are_ going to die.

With medical treatment and some modicum of foresight (ice packs etc) it's quite manageable. Just really really unpleasant. People sure *feel* like they're going to die though.

Generally however, it takes some serious drugs to cause SS. It's likely that if you are on a SNRI and you try to take MDxx type drugs - methylone included - you'll just get no effects of note because the MDMA or whatever is blocked from binding by your antidepressant. But the possibility exists that the MDMA could produce some sort of effect and leave the serotonin (or norepinephrine) to build up to dangerous levels. (In this case I would be more immediately concerned about the buildup of norepinephrine causing panic, raised heart rate, anxiety and other nasty hypertensive shit)

Just treat methylone like you would MDMA. Don't mix it with SNRIs, it will give you shitty results at best and become a danger at worst (if you push your dosing to dangerous levels). It is basically the same in terms of effects when compared to MDMA with some minor alterations (releases lightly more norepinephrine than serotonin, less potent all round, different duration). Both drugs are monoamine releasing agents/reuptake inhibitors.

Also, taking even small doses of MDxx compounds on a daily basis is probably not going to be worth your while; they build tolerance incredibly quickly and if you are depressed/anxious the last thing you really need is exposure to monoamine depleting drugs on a regular basis. MDxx really shines in the higher dose levels, it leaves quite a lot to be desired if you lowball the dose.

TL;DR: Don't bother, methylone works the same way as MDMA. Either get off the SNRI or find a different class of drugs to use.

 

[optimuswind]

With medical treatment and some modicum of foresight (ice packs etc) it's quite manageable. Just really really unpleasant.

It's most likely that if you are on a SNRI and you try to take MDxx type drugs - methylone included - you'll just get no effects of note because the MDMA or whatever is blocked from binding by your antidepressant.

Just treat methylone like you would MDMA. Don't mix it with SNRIs, it will give you shitty results at best and become a danger at worst (if you push your dosing to dangerous levels). It is basically the same in terms of effects when compared to MDMA with some minor alterations (releases lightly more norepinephrine than serotonin, less potent all round, different duration). Both drugs are monoamine releasing agents/reuptake inhibitors.

TL;DR: Don't bother, methylone works the same way as MDMA.

Thanks for the reply! So you are thinking I probably will either feel nothing, or I would need to take a dangerous amount in order to feel anything?
I already have 3g of the stuff lying around from last time I used it, and based upon your reply it should be ok to at least *try* a small dose and see if anything happens.

I remember being on benzos and trying mushrooms/LSD. Absolutely no effect whatsoever, mind or body. Maybe it'll be the same with this, and if so, I won't increase the dose because as you say could become a danger.

Thanks again for the reply.

Also, taking even small doses of MDxx compounds on a daily basis is probably not going to be worth your while; they build tolerance incredibly quickly

I guess you were editing your post as I was typing my reply. I've had it in the past and yes, tolerance built up for me after about 5 days and then I crashed and felt severe de-realization for about 2 months, I know to be careful with it now and use it very sparingly (if it turns out to have any effect at all)

Thanks once again for your insight.

 

[blazR]

So you are thinking I probably will either feel nothing, or I would need to take a dangerous amount in order to feel anything?

Yes exactly mate. Save it till you are of the medication

 

[optimuswind]

Alright, so I got 3g of Methylone, I started with 50mg and waited about an hour, I could feel it working and even a bit of euphoria, re-dosed with 100mg and it lasted a bit longer but then the stimulant-effect it gives sort of wore off and I was really tired. I had a slight headache later that night, and it was gone by morning. I took 300mg today and it lasted about 2 hours at its peak and then slowly dropped over the next 2 hours. No headaches or anything else to suggest serotonin syndrome, so it seems I can still take small amounts and feel it. Also, I noticed I didn't sweat as much as I used to when I took M1, I used to sweat from my forehead pretty badly, but as long as I wasn't constantly walking around my temperature stayed fine and I didn't sweat much at all. Not sure if that's a good sign or bad one, but anyway I read that serotonin syndrome can be from minor things like headaches to serious life-threatening etc, and so if I feel like it's getting bad I know to down a bunch of valium that I always carry on me and then call an ambulance, but I doubt it will get serious from 1-2 times a week usage at these doses. Just to be safe though I even printed off a peice of paper with what drugs I may have taken and hidden it in my wallet just because I was paranoid I might start seizing on the sidewalk or something, would help paramedics/doctors know what could be wrong.

I was wondering though, is there perhaps a better entactogen that doesn't mess with serotonin? I've briefly heard of these 2C-X substances but I don't really know how they compare or work etc, so anyway, is there anything else I can use as an entactogen that may be safer/better than methylone?