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  • EADD Moderators: Shambles

Methylone Megathread

Thanks for the confirmation. I think a lot of people have asked about methylone and drug tests, and your experience is the first source I think we've seen on BL.
 
aye, that was another reason for doing it. i could never find anything about it here or on erowid.

all part of the service. ;)
 
UnfortunateSquid said:
Something just seems not quite right about mephedrone to me. Just a gut feeling, and one I have nothing concrete with which to back up.

This thread inspired me to spunk away £quiteabit on methylone :(:D
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Well 4-methylamphetamine isn't nice stuff (4-hydroxylation of amphetamine/meth is one of the primary metabolic routes, which is effectively blocked) and making the leap that mephedrone is beta-keto-4-methylmethamphetamine is enough to convince me that it's one that I'm happy just to read about others experience with it. I know MDA isn't too wonderful either, but it still appears to be a lot safer than 4-methylamphet, so by extention, methylone is something I'm willing to ingest - in fact I prefer it to MDMA as I don't get a crippling depression 2-3 days after using it (another indicator that my hideous comedown from MDMA is due to the metabolite alphamethyldopamine as methylone can't be metabolized to alphamethylDA, just alphamethylnoradrenaline, which I've seen no evidence that it causes clinical depression), even though it's entactogenic activity is only a fraction of MDMA; but then again MDMA feels like forced artificial happiness (very plastic,"you will love everyone, even the twats" feel) whereas methylone feels much more natural and therefore genuine.

My only issue with methylone is that it's like Pringles - once you pop you can't stop. If I went out with a gram of it in my pocket I'd have none left the next day (not sure if that's because I use it via rectal administration though). I have tried IMing it once (90mg), but wouldn't recommend it as the nausea was quite pronounced - obviously that'd be even moreso should anyone IV it.


for the record, methylone shows up as methamp on a urine drugs test the day after. i don't suppose that'll be too much of a surprise,
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It is to me as in such as the Marquis test, methylenedioxy based drugs have a totally different reaction to amphetamines (it's the methylenedioxyphenyl bit that produces the dark purple colour as opposed to the orange brown of the amphetamines, which are in comparison just phenyl). Had it shown up as MDMA I wouldn't have been in the least surprised, but methamphetamine (does MDMA show up as meth in the same test?)


MDMA hasn't been proved to be neurotoxic to humans.
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Anything that spews out serotonin & dopamine in bucketloads from the neurones is going to be neurotoxic (that's how meth is neurotoxic in humans - the serotonin neurones end up reuptaking dopamine which after metabolism produces free radicles which thouroughly fuck it) and MDMA does exactly the same thing as meth, only at slightly different levels, so using the above arguement is a bit 'sticking your head in the sand'-ish. Even methylone is going to have some degree of neurotoxicity as it causes dopamine & serotonin release.

Anyway MDMA has been proved to be neurotoxic in primates and unlike rats where you can't just extrapolate the data, primates are so closely related that anything that fucks primates is going to fuck humans in an identical manner, therefore it's an odds on certainty if some Mengele type character did experiments with humans, it'd be proved neurotoxic
 
fastandbulbous said:
if some Mengele type character did experiments with humans, it'd be proved neurotoxic
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correct. the test subject, known as 'spade', did not respond positively to my experiments over a 5 year period and now exhibits severe mongolism with flashes of spazzicism. :\
 
rather than feeling anxious and sad, with loss of lust for life like on an mdma comedown

a methylone comedown seems very like all my energy and oomph is gone. like a speed comedown except no real depression or sense of despair or anxiety. just tired for three days with a strong desire to lie down.

mephedrone is shockingly good though
 
i don't get a comedown from methylone, really. just a need for sleep afterwards and i'm fine after that. mind over matter, kids. ;)

fastandbulbous said:
^ Do we get the full list of your experimental test subjects so we know who not to use big words to communicate with? =D =D
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sorry, The Kid, UnfortunateSquid and Shambles have sworn me to secrecy. my lips are :|
 
felix said:
sorry, The Kid, UnfortunateSquid and Shambles have sworn me to secrecy. my lips are :|
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Too fuckin right, or Felix will be going out like Luca Brasi. ;)
 
fastandbulbous said:
Anyway MDMA has been proved to be neurotoxic in primates and unlike rats where you can't just extrapolate the data, primates are so closely related that anything that fucks primates is going to fuck humans in an identical manner, therefore it's an odds on certainty if some Mengele type character did experiments with humans, it'd be proved neurotoxic
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What do you think something being neurotoxic amounts to in reality tho? I know if you cut Mr Rattys brain open and have a look at the receptors you notice something different but what happens if you just let him go in a group of other rats - would he live as perfectly healthy a life as any rat who hadn't been experimented on?
 
My only issue with methylone is that it's like Pringles - once you pop you can't stop.
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That describes MDMA for me, no desire to re-dose with methylone.
 
Shut up! Why are people allowed to say how much they like / love methy without anyone passing comment but I'm not allowed to state my opinion on the subject.

Get a grip of yourself and stop following me around making un-humorous and sarcastic comments.
 
Calm yer jets Spade!

It's all in jest :D

Feel free to post your opinions. I think we already know what they are but go for it. One more time couldn't hurt. ;)
 
Ismene said:
What do you think something being neurotoxic amounts to in reality tho? I know if you cut Mr Rattys brain open and have a look at the receptors you notice something different but what happens if you just let him go in a group of other rats - would he live as perfectly healthy a life as any rat who hadn't been experimented on?
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Well it's a change in functioning that impairs the overall performance of the neurone. \this goes from things like observed reduction of the number of vesicles containing neurotransmitter, through seeing a reduction of the number of contacts with other nerve cells through to total cell death. MDMA probably has a little of the first two, such that it can lead to say less stabnility in mood control later on in life (things like viral infections & psychological trauma eg PTSD can cause as well though), but with some neurotoxins, it can be a sight more serious eg extremely severe Parkinson's disease from contact with MPTP (the impurity in the 'designer heroin' that fucked up a lot of people in California).

As for Mr Ratty, it depends on the identity & amount of the neurotoxin, just like with humans
 
Perhaps slightly offtopic, but F&B, do you have studies that emperically verify the neurotoxicity of dopamine uptake by serotonergenic neurons at normal or at least reasonable dosage ranges?

I had a discussion on another forum last week, and I explained this mechanism, but they wouldn't accept it without a study to back it up. For me it's reason enough not to take MDMA again (tried it once), but I'ld like to be able to back up my opinion emperically. I couldn't find any studies that I understood enough to be able to convince other with them, so I UTFS on various sites.
 
^ I'll rummage through my hard drive & pull out the studies on that (hopefully as I've got a large number of PDFs just labelled 'Nichols paper no 032' etc that I never got around to naming correctly (I know - it's shamefully lazy on my behalf).

Alternatively you could try googling combinations of dopamine, serotonogic neurones, neurotoxicity etc then separate out the definitive research papers


Actually here's one paper on the NIDA site

Use of Antisense Technologies To Study the Role of Dopamine in MDMA Neurotoxicity
Jon E. Sprague, Ph.D., Arthi Kanthasamy, Ph.D., David E. Nichols, Ph.D.
 
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Is there much of a "cross-tolerance" in any way between MDMA and methylone, on a mental as well as a physical level (that probably doesn't make sense...) like... if someone who's used to taking methylone tried MDMA, could they be underwhelmed? Or could taking a break from MDMA be less effective if you use methylone a fair bit during this period...? Just wondering about cross-tolerance, as i'm no chemist!
 
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