• Psychedelic Drugs Welcome Guest
    View threads about
    Posting RulesBluelight Rules
    PD's Best Threads Index
    Social ThreadSupport Bluelight
    Psychedelic Beginner's FAQ
  • PD Moderators: Esperighanto | JackARoe |

Methylone and Methoxetamine

Bit obvious which vendor your using with the chemicals listed (or that could be a coincidence). :D

I know that MDMA and Ketamine are supposed to mix well so this sounds like it could be a winner too.
 
MDMA and Ketamine is one of my Favourites. I guess it would be nearly the same woth Methoxetamine+MDMC...
 
I can't wait to try methoxetamine, is it similar to ket? I hope methylone and methoxetamine have synergy like MDMA and ket do.
 
there is thread with mxe combos somewhere on here. i remember reading some people said mixing mxe with emphatogens its not good idea at all.
 
I would be very cautious with this combo, personally. This is not the same as methylone + ketamine; methoxetamine is a DARI and a D2 partial agonist, among a slew of other things (it most likely has a broad binding profile: NMDA antagonist, (partial?) mu agonist, sigma agonist, K+ channel blocker, NACh antagonist, etc etc and who knows what, what I'm saying is that its not so easy to predict the safety of combinations with MXE).

My instinct seems to tell me that methoxetamine's dopaminergic pharmacology might be more similar to PCP than to ketamine. I obviously don't have any data to back that up, as MXE is unstudied, but its just a feeling I have. Anyways, given how cracked-out and dopamine fueled methylone can be-- especially after redosing-- I would honestly be pretty hesitant to combine it with MXE.

Fuck being a guinea pig, ya know?
 
what Roger&Me said...

tread lightly. small doses of both to start, if you insist on trying this at all. be careful.

I have combined the two in small doses... (~25mg MXE, ~50mg Methylone, plus a few beers and some ganja) and all was okay. I do not feel it would be a good idea to push the doses into full Methylone dose territory combined with a substantial dose of MXE.
 
This combination has produced significant adverse effects in some users. I would definitely recommend avoiding it.
 
So methylone causes release of dopamine into the synaptic cleft and methoxetamine prevents reuptake of this dopamine back into the presynaptic nerve terminal. I can think of two things that happen:
- one is that you might 'spend' less dopamine, in this situation a little goes a longer way right?
- another is that it could much more easily be too much, it is more unpredictable and potentially more toxic, overstimulation side-effects as well as cardiovascular problems may occur.

I would personally say the second is not worth the first and I'd avoid it. Methoxetamine seems bad combined with any dopaminergic compound.

edit: apparently serotonergic ones are also not a smart idea though I have read about lots of people who liked it. Doesn't make it safe though!
 
Last edited:
i had no problems combining mxe with meph ... had a few 30-40mg lines after the meph ran out , on a nite back from the pub. there was no bad reactions it was just very very wierd...8o it was like a cartoon with all of us robot walking and reading eachothers minds... or maybe just we were so slow to react that we all thought the same thing...=D
 
Last edited:
yeah wasnt a bad nite tho.. and as always i measured out safe doses for my friends.. my gf didnt want any and i walked her home .... after a while i cudnt remember i had gave here some or not ...and was going crazy tring to ring her to make sure she was in bed and ok..
 
You must log in or register to reply here.
Top