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  • EADD Moderators: Pissed_and_messed | Shinji Ikari

Methoxetamine - Tell Us More

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got some more sexy mexy today in the post. might try a small amount sunbatheing on a beach somewhere this weekend. or i may go to a rave on a small amount, always seem to get a nice euphoric liquidy feel to it
 
is never responsible to cut drugs, especially if it was just done by mixing two powders together and shaking around, as that could result in one pile of 50mg containing 50mg mxe and another pile of 50mg containt 50mg cut. Is pretty dangerous to cut drugs.
 
Limpet_Chicken said:
but have some piracetam on the way to help regrow all the NMDA receptors I doubtless fried crispy
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Interesting, what are you basing this on?

I thought use of NMDA receptor antagonists leads to more receptors growing rather than killing off the existing ones? Although I can't remember where I read this and it might be completely wrong.
 
i've known a few heavy ketamine users to swear by piracetam to repair any cognitive negatives, i noticed quite extreme short term cognitive impairment (dysnomia and generally poor short term memory) from ketamine abuse and have problems with them to this day though couldn't pin them down to being from dissociative abuse.
 
I'm basing it on the fact that NMDA receptor expression is under the control of overall input, rather than agonist/antagonist induced up/downregulation.

The more stimulation of NMDARs by AMPAr-mediated excitatory signalling, the more they are needed, and synaptic plasticity results in insertion of more NMDARs at the synapse.

Antagonists lessen receptor activation of course, thus in this case, resulting in downregulation of expression. piracetam (and to a greater extent aniracetam, went for piracetam though as I got a cheap deal on a half kilo tub of the stuff)
 
Limpet_Chicken said:
Antagonists lessen receptor activation of course, thus in this case, resulting in downregulation of expression. piracetam (and to a greater extent aniracetam, went for piracetam though as I got a cheap deal on a half kilo tub of the stuff)
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Don't think you finished your sentence, please keep going!

Evad said:
i've known a few heavy ketamine users to swear by piracetam to repair any cognitive negatives, i noticed quite extreme short term cognitive impairment (dysnomia and generally poor short term memory) from ketamine abuse and have problems with them to this day though couldn't pin them down to being from dissociative abuse.
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What intake would you categorise as abuse rather than use?
 
Oops....blame the MXE for that=D

I was GOING to say, that piracetam (and more so aniracetam) act as allosteric positive modulators at a binding site on AMPARs.
 
I remember reading a long time ago somewhere that ketamine causes certain neurons to grow back deformed, not sure where I read that though might be nonsense
 
Been really appreciating small doses of mxe today, not been fucked all day but I have found it to lift my mood quite a lot, I have just been in a more positive mindset, it is a lovely drug with great antideppresant qualitys. But now it's the end of the day and I've decided to enjoy the write off line!:)
 
knockando said:
Not sure what was responsible about cutting it. It's perfectly possible to prepare, say, 25mg doses, in wraps.

I see no advantage whatsoever to cutting it.
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They said it was machine blended when manufactured 50/50 because they felt it is too strong to be put out to the general k head market /ravers because if people do K size lines without fully knowing what they were doing there could be casualties. Alot of people have never heard of this chemical let alone learnt about it from these forums. (which is pretty much the only place i know where you can get info on MXE)

I dont know that it would be that great to do a normal largeish line of what you thought to be K and it end up being a 150mg line of MXE .....
 
Then the people that would do 150mg lines simply shouldn't be doing methoxetamine. That is my opinion anyway. If people want to do research chemicals then they should do the research first and not just sniff a massive line because that is what they are used to doing with K.

It is like saying that all spirits should be watered down to stop people from drinking pints of whisky and vodka. When all that is needed is for people to be educated about the strength and dosages of the two different forms of alcohol.

They said it was machine blended when manufactured 50/50
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That is also one of the most bullshit quotes that I have heard, still wouldn't produce an exact 50/50 split, do you even know what the cut was?
 
Rasclatt said:
7 gs a day is cool though
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haha I was just saying my own use as what i was classifying as abuse not giving guidelines :)
when your cramping up regularly and your piss is always dark brown and needs to be evacuated every half hour then you def know you've hit abuse
 
Cannabis + K made me feel braindead. Hated it. Cannabis (at LOW doses) + MXE is enjoyable and funky, but when I take a bong hit (versus a toke from a joint) I'm launched into this unmanageable world of smeared-pastel confusion. I prefer MXE alone, and plugged. Nursing a single beer with a cigarette during the comedown can be a pretty nice way to end the experience, too, but as others have said, this isn't Ketamine. Close, yet SO far away. The Bermuda Triangle of stimulation - that is, mu-opioid receptor agonism, dopamine reuptake inhibition and NMDA antagonism make this material quite a find - but remarkably close to the concept of the "perfect storm," ESPECIALLY where one with an addictive personality is concerned.

~ vaya
 
Darkened coloration of, and frequent need to pass urine is suggestive of kidney damage, and/or rhabdomyolysis, which is when muscle tissue gets attacked and broken down, and floods the kidneys with toxic degredation products, potentially resulting in kidney failure.

Or alternatively haemolysis.

Neither is good, of course.
 
Or haematuria originating from the bladder due to interstitial cystitis in this case.
 
, this isn't Ketamine. Close, yet SO far away.
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LOL. I'm in the same boat! First experience with MX£ (i left it like that 4 a reason) last nite.
On it now. Its good stuff but so obviously Katering for a nation. =D

on a side note/fucked thread: buphedrone+4-MEC = mindblowing orgasms!
MXE+dubstep=:)

back in a while. ethcath calling maybe
 
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