pofacedhoe
Bluelight Crew
i'm with you on this- i get itching when coming down in the afterglow stage- and the next day at work i yawn a lot more than ussual, also been having sloppy shits the next day which i always get after using an opioid...
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Trip Reports Moderator: M!$ter-ED
Methoxetamine (MXE) - First Time - From An Experienced K Lover.
- Thread starter phatboy303
- Start date
i'm with you on this- i get itching when coming down in the afterglow stage- and the next day at work i yawn a lot more than ussual, also been having sloppy shits the next day which i always get after using an opioid...
Serene Imp
Bluelighter
Great report. My guy wanted to try this, he's a huge K fan and kinda got me into it. We've stopping do it for a while now though. Anyways, he wanted to try this really bad. The shallow breathing kinda makes me not want him to try it. When he used to IM K (before I ever tried it) he'd fall fast into a hole and his breathing would scare the crap out of me. He'd be fine and just laying there then his breathing would go really shallow with long pauses in between then he'd gasp and go back to breathing normal.
Since you've never had breathing issues on K but you did on this would it be safe to say that since he has on K he shouldn't try this cause it might get very dangerous?
Since you've never had breathing issues on K but you did on this would it be safe to say that since he has on K he shouldn't try this cause it might get very dangerous?
nuke
Bluelighter
- Joined
- Nov 7, 2004
- Messages
- 4,190
As to the opioid comment:
I've pretty sure F&B&Co's original synthesis and investigation of this compound was related to the known structure activity relationships between NMDA agonists and Mu-opioid receptor agonists, in an attempt to bridge the two compounds in an ideal way. Therefore, yes, it should have Mu-opioid receptor agonistic effects.
I think this may become a very serious drug of abuse over the next decade and especially the next few years.
I've pretty sure F&B&Co's original synthesis and investigation of this compound was related to the known structure activity relationships between NMDA agonists and Mu-opioid receptor agonists, in an attempt to bridge the two compounds in an ideal way. Therefore, yes, it should have Mu-opioid receptor agonistic effects.
I think this may become a very serious drug of abuse over the next decade and especially the next few years.
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pofacedhoe
Bluelight Crew
As to the opioid comment:
I've pretty sure F&B&Co's original synthesis and investigation of this compound was related to the known structure activity relationships between NMDA agonists and Mu-opioid receptor agonists, in an attempt to bridge the two compounds in an ideal way. Therefore, yes, it should have Mu-opioid receptor agonistic effects.
I think this may become a very serious drug of abuse over the next decade and especially the next few years.
its something i have tried quite few times now and i'm knowhere near bored of it, i seem to gain something different from it every time, maybe k heads dont get as much depth out of it.
taking it the morning after drinking it feels a LOT more like ketamine (with all the alcohol still in the system), also superior oral to nasal
deckmunki
Bluelighter
Interestingly, despite all the reports of opioid effects (opioid agonism?), I have been using consistently at small (10-20mg) doses over the last 3 weeks with very little in the way of a break (nearly finished 3g since Dec 18th - very silly, I know!) and went completely cold-turkey a couple of days ago with no noticeable ill-effects.
HR and BP have gone up slightly (no more than 10%) at rest over this time, and I do cardio at the gym 3 or 4 times a week, around 20 minutes of intensive use per session, without any noticeable health concerns apart from this slightly raised resting HR.
In particular, aerobic efficiency hasn't been noticeable affected; I can still do the same amount of exercise at the same intensity.
Of course, this doesn't prove anything, and this certainly isn't carte blanche for anyone looking for the slightest excuse to do their best to abuse this drug, so be careful!
Lots of gloves,
/D
HR and BP have gone up slightly (no more than 10%) at rest over this time, and I do cardio at the gym 3 or 4 times a week, around 20 minutes of intensive use per session, without any noticeable health concerns apart from this slightly raised resting HR.
In particular, aerobic efficiency hasn't been noticeable affected; I can still do the same amount of exercise at the same intensity.
Of course, this doesn't prove anything, and this certainly isn't carte blanche for anyone looking for the slightest excuse to do their best to abuse this drug, so be careful!
Lots of gloves,
/D
amanitadine
Bluelighter
As to the opioid comment:
I've pretty sure F&B&Co's original synthesis and investigation of this compound was related to the known structure activity relationships between NMDA agonists and Mu-opioid receptor agonists, in an attempt to bridge the two compounds in an ideal way. Therefore, yes, it should have Mu-opioid receptor agonistic effects.
I think this may become a very serious drug of abuse over the next decade and especially the next few years.
With all due respect, I dunno about that Nuke. I thought the 3-position was just proving to be an exciting modification (with some of its brethren) , and the possibility of MOR agonism was just icing on the cake? But pharmacologically it doesn't seem that clear, and subjectively even less clear. A bit of discussion in the bigger thread....seems pretty inconclusive as to whether Methoxetamine has any significant effects on the MOR. But this aint exactly my forte, and a clear, quantifiable answer or explanation would be much appreciated, if you have such?
But I agree 100% about the potential for abuse. Most agree it isn't quite as abuseable as ketamine however....it is pretty self limiting as far as binging goes.
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phatboy303
Bluelighter
Ketamine is often used in a medical setting
I would say if your friend does have shallow breathing in a k-hole it may be wise to avoid this one. Perhaps someone could expand on the pharmacology of this.
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phatboy303
Bluelighter
Actually, since my earlier post where I said I felt that I'd explored this one fully, I've since delved further into mixing MXE with K.
I find spicing K up with a small amount of this <50mg adds a whole new twist to ketamisation, it seems to bring a degree of mania while retaining the lucidity of ketamine, and can actually be quite entertaining having a bit of intentional fun with the madness. The other night I had an argument with the bin, telling it that it was rubbish and just a metaphor while I proceeded to empty it (it was funny at the time, you'd probably have to have been there)!
Nevertheless with a new year, I have a determination to clean myself up a bit and get on with more productive activities so i will be laying off this for a while at least, i intend staying off the K too.
I find spicing K up with a small amount of this <50mg adds a whole new twist to ketamisation, it seems to bring a degree of mania while retaining the lucidity of ketamine, and can actually be quite entertaining having a bit of intentional fun with the madness. The other night I had an argument with the bin, telling it that it was rubbish and just a metaphor while I proceeded to empty it (it was funny at the time, you'd probably have to have been there)!
Nevertheless with a new year, I have a determination to clean myself up a bit and get on with more productive activities so i will be laying off this for a while at least, i intend staying off the K too.
benjalex
Bluelighter
I had 90mg of this last night split between 2 lines, an hour apart, I must say, one of the most amazing experiences of my life! Feel like I wanna die today sat at work, but that's my fault for trying on a school night ;-)
I'll have to write up my report and get it posted when I'm feeling able to put into words what I was feeling!
I'll have to write up my report and get it posted when I'm feeling able to put into words what I was feeling!
Had a decent amount of this, 100% confirmed substance as well as quality 98% pure. Was given a recommendation of 20mg initial dose (insufflated) to start off with (after a 1mg allergy test of course 
)
Decided to go the safe route with the dosing as I tend to overwhelm myself by overestimating my k tolerance or by dosing large due to becoming accustomed to the shit quality of k in my area... I didn't want to put myself in a mental state I would have had trouble dealing with for (from what I had heard and read) 4 hours.
Did 10mg and found myself with some mood elevation and some slight dissociation after about 15 minutes. At the 20 minute mark decided to go for the other ten. This was an excellent idea. I found myself in a very silly headspace, giggly and slightly energetic but also relaxed, like I could sit on my couch for hours. Which I did. I spent a significant amount of time on the spacetribe website as well as elftrance.
I was fairly surprised by the sedation of my peers. Two fell asleep, while the other was doing incremental doses of MMC (actually MMC mixed with MDPV and sold as drone) as well as MEC mixed with MDPV(MDPV in this mix was unsuspected at the time) and small bumps of 5-methyl-MDA (or so we thought. Have since learned that the info on this chem is entirely unreliable and am waiting for a sample that is meant to confirm that it is entirely ineffective. I suspect he may have had one of the APB's given the description of effects...) Anyway, I digress...
Only the two of us really stayed awake for the entire length of the experience. I thought it was pretty, like the contrast and definition nob had been turned up on my vision. Unlike my experiences with k, which often leaves me overwhelmed, doing what I can to maintain my grip on reality as I switch from mental tv station to mental tv station, all playing the same show, with a different plot, and the same characters in different roles. Hard to explain, but that is the best I can do. MXE was clear minded, and easy to control. My movements were somewhat labored, doing the lovely K-walk (or M-walk i guess) to get to my deck and see the 'super moon' or whatever.
At this dose, it was manageable, entertaining visually and mentally, physically relaxing (the talk of opiate like effects are spot on). But maintaining a strange stimulation that lingered for quite some time after the other effects had dissipated.
Overall, I give it a 7 out of 10. Same place I would put K on that scale. I don't think it is a replacement for K. It does share effects, for sure, but it is also, by several first hand accounts, kind of like a thinking man's k. The dissociation maintains a strange level of clarity. The duration is excellent in a city where time from open to close of a club is often 10-2, just enough time to do a line before and be sober when the music stops. It also decreases the inherent risk of being discovered bumping up... And the actual legality of it, being a schedule 3 analogue, makes it zero risk and very favorable. But, it comes up much slower, making it useless as trailmix component as that requires the rush of both happening at once. It is not the immediate insanity of k, overwhelming if unprepared, it is gentler but this softness makes it less enticing for certain situations where extreme dissociation is desired. And, the long duration takes away that ability of k to almost be an anytime/anwhere thing because, well, you'll be sober in 20 minutes...
Upon some further experiments, I have come to the personal conclusion that MXE is a neurotropic. I feel as though it heightens the senses and allows you to see, hear, feel, taste and smell at an accelerated rate. But, your motor skills are still dampened like an opioid or ketamine. Most of the people who have tried this stuff have labeled it 'super k'. Not just because of duration, but also clarity and potency.
MY evidence for the neurotropic properties is one instance in particular (there are many other less apparent instances, this one just stuck out). I had done around a quarter gram over the course of 4-6 hours (estimate) starting, for the first time, from a sober mind. Near the end of my night, I was sitting talking to my girlfriend when I realized I no longer felt all that dissociated, even though I had done a 50mg bump no more than a half hour prior.
I explained to my girlfriend how I was seeing things clearly, like in real life HD. I felt as though I was processing information at an incredibly high rate. Like a cartoon character that has drank way tooo much coffee and is moving far faster than his peers, processing things and moving around at a superhuman speed. Think Fry from Futurama when he drinks 100 cups of coffee and saves everyone from the fire. I had a perfect memory of the day prior, before the trip, recalling dertails I personally don't think I should have been able to recall. I felt an incredible mental clarity. Almost sober.
After searching for a reason as to why this experience was so much clearer, and so suddenly clearer than any other, I honed in on one answer. I had drank a Coca Cola. Regular, Coke classic. With all that lovely sugar. It could not have been the caffeine, I live off that shit, I drink so much diet soda I am probably more preserved than a can of Smuckers.
The sugar rush was absolutely the most intense i had ever experienced. I was hyper alert, and responsive, essentially all the effects attributable to a sugar rush. Except they were amplified 100 times. It was extremely similar to instances of taking piracetam and another chemical and noticing the increased effect of the other chem.
This one is a winner in my book. It just needs to be treated with the same respect as any other RC. If people do stupid shit, they will hurt themselves. No different than anything else that nobody knows anything about. It is mildly frustrating that people seem to forget that so frequently on here. Ultimately, anything can be done with a reasonable amount of caution and safety. The problem is, people don't or won't listen or pay attention. Hurt, attention, labeling, monitoring, regulation, prohibition. I don't recommend anyone do more than 50mg of this at once, for psychological reasons. It could freak someone out if they aren't ready for it.
)Decided to go the safe route with the dosing as I tend to overwhelm myself by overestimating my k tolerance or by dosing large due to becoming accustomed to the shit quality of k in my area... I didn't want to put myself in a mental state I would have had trouble dealing with for (from what I had heard and read) 4 hours.
Did 10mg and found myself with some mood elevation and some slight dissociation after about 15 minutes. At the 20 minute mark decided to go for the other ten. This was an excellent idea. I found myself in a very silly headspace, giggly and slightly energetic but also relaxed, like I could sit on my couch for hours. Which I did. I spent a significant amount of time on the spacetribe website as well as elftrance.
I was fairly surprised by the sedation of my peers. Two fell asleep, while the other was doing incremental doses of MMC (actually MMC mixed with MDPV and sold as drone) as well as MEC mixed with MDPV(MDPV in this mix was unsuspected at the time) and small bumps of 5-methyl-MDA (or so we thought. Have since learned that the info on this chem is entirely unreliable and am waiting for a sample that is meant to confirm that it is entirely ineffective. I suspect he may have had one of the APB's given the description of effects...) Anyway, I digress...
Only the two of us really stayed awake for the entire length of the experience. I thought it was pretty, like the contrast and definition nob had been turned up on my vision. Unlike my experiences with k, which often leaves me overwhelmed, doing what I can to maintain my grip on reality as I switch from mental tv station to mental tv station, all playing the same show, with a different plot, and the same characters in different roles. Hard to explain, but that is the best I can do. MXE was clear minded, and easy to control. My movements were somewhat labored, doing the lovely K-walk (or M-walk i guess) to get to my deck and see the 'super moon' or whatever.
At this dose, it was manageable, entertaining visually and mentally, physically relaxing (the talk of opiate like effects are spot on). But maintaining a strange stimulation that lingered for quite some time after the other effects had dissipated.
Overall, I give it a 7 out of 10. Same place I would put K on that scale. I don't think it is a replacement for K. It does share effects, for sure, but it is also, by several first hand accounts, kind of like a thinking man's k. The dissociation maintains a strange level of clarity. The duration is excellent in a city where time from open to close of a club is often 10-2, just enough time to do a line before and be sober when the music stops. It also decreases the inherent risk of being discovered bumping up... And the actual legality of it, being a schedule 3 analogue, makes it zero risk and very favorable. But, it comes up much slower, making it useless as trailmix component as that requires the rush of both happening at once. It is not the immediate insanity of k, overwhelming if unprepared, it is gentler but this softness makes it less enticing for certain situations where extreme dissociation is desired. And, the long duration takes away that ability of k to almost be an anytime/anwhere thing because, well, you'll be sober in 20 minutes...
Upon some further experiments, I have come to the personal conclusion that MXE is a neurotropic. I feel as though it heightens the senses and allows you to see, hear, feel, taste and smell at an accelerated rate. But, your motor skills are still dampened like an opioid or ketamine. Most of the people who have tried this stuff have labeled it 'super k'. Not just because of duration, but also clarity and potency.
MY evidence for the neurotropic properties is one instance in particular (there are many other less apparent instances, this one just stuck out). I had done around a quarter gram over the course of 4-6 hours (estimate) starting, for the first time, from a sober mind. Near the end of my night, I was sitting talking to my girlfriend when I realized I no longer felt all that dissociated, even though I had done a 50mg bump no more than a half hour prior.
I explained to my girlfriend how I was seeing things clearly, like in real life HD. I felt as though I was processing information at an incredibly high rate. Like a cartoon character that has drank way tooo much coffee and is moving far faster than his peers, processing things and moving around at a superhuman speed. Think Fry from Futurama when he drinks 100 cups of coffee and saves everyone from the fire. I had a perfect memory of the day prior, before the trip, recalling dertails I personally don't think I should have been able to recall. I felt an incredible mental clarity. Almost sober.
After searching for a reason as to why this experience was so much clearer, and so suddenly clearer than any other, I honed in on one answer. I had drank a Coca Cola. Regular, Coke classic. With all that lovely sugar. It could not have been the caffeine, I live off that shit, I drink so much diet soda I am probably more preserved than a can of Smuckers.
The sugar rush was absolutely the most intense i had ever experienced. I was hyper alert, and responsive, essentially all the effects attributable to a sugar rush. Except they were amplified 100 times. It was extremely similar to instances of taking piracetam and another chemical and noticing the increased effect of the other chem.
This one is a winner in my book. It just needs to be treated with the same respect as any other RC. If people do stupid shit, they will hurt themselves. No different than anything else that nobody knows anything about. It is mildly frustrating that people seem to forget that so frequently on here. Ultimately, anything can be done with a reasonable amount of caution and safety. The problem is, people don't or won't listen or pay attention. Hurt, attention, labeling, monitoring, regulation, prohibition. I don't recommend anyone do more than 50mg of this at once, for psychological reasons. It could freak someone out if they aren't ready for it.