Methoxetamine as a painkiller

[AA357]

There are loads of reports out there on MXE, but they are almost all centered around the psychological/dissociative effects of the drug.
Whilst I do consider MXE very euphoric, what I like about it most is its effectiveness as an anesthetic. It doesn't just dull pain... it totally numbs you out. For extreme pain it's way better than opioids.
If I snort 100-150mg I feel like a floating head. Somehow I can still walk around, but the numbness is so deep and penetrating I can barely feel anything. I did this after getting injured in a car crash one time. I was in a lot of pain and my hip was pretty fucked, but once the drug kicked in I literally felt no pain whatsoever.
Last night I snorted 75mg after being woken up by a toothache that had tears streaming down my face (this happened even though I had taken codeine before bed). 20 minutes later the pain was all gone.

I can function pretty well on doses of 75mg or less and it's actually quite nice in the gym. It's very spacey but it doesn't have the sedative/muscle-relaxant properties of opioid painkillers (which tend to put me on my ass).

I know it's intensely psychoactive, but its anesthetic qualities are underreported. I know people who have MXE in their possession but never get the idea to use it when in pain (they only think about it when they want to get smashed). If you're a fan of MXE you should realize that what you have isn't just a recreational drug - it's also an incredibly powerful painkiller.

 

[ihearthemoose]

What exactly is mxe? A stimulant?

 

[Toz]

What exactly is mxe? A stimulant?

It's a NMDA receptor antagonist (dissociative aneasthetic).

I suffer from neuropathic pain and NMDA receptor antagonist will dull almost all pain for the duration of the drug. However, resensitization of the nervous system seems to double the pain or even worse when the drug leaves the system. And repeated doses of NMDAR-antagonists tend to make me horribly depressed after a while. It will also cause muscle cramps with repeated administration unless a GABAergic is administered simultanousely in my experience.

I guess it's all about finding the right dose / dosage intervals which can seem troublesome. Though I never tried to do it with MXE only with 3-meo-pcp which has a much less forgiving dosing scheme.

Also, permanent down-regulation of the NMDA receptor system is not something you will want, trust me on this one.

 

[AA357]

What exactly is mxe? A stimulant?

It's an NMDA antagonist so it primarily acts a dissociative anaesthetic. MXE is structurally similar to PCP and ketamine, but more similar to PCP in terms of effects (it's basically PCP-lite). Both MXE and PCP increase dopamine levels (MXE as a re-uptake inhibitor and PCP as a releaser) which does lends to them a stimulant quality. After waking up and snorting that 75mg MXE, I spent an hour on my laptop before falling asleep again.
Unlike analgesics (which simply dull pain), anaesthetics cause loss of sensation. Take enough of this type of drug and you'll be impervious to pain - ketamine is sometimes used as a surgical anaesthetic (PCP also was years ago but this got stopped because of the psychotogenic effects)
The stimulant quality is very nice... while it is quite spaey, I find it so much easier to function on a moderate dose of MXE than any opioid painkiller. Opioids make me feel all sloppy and weak whereas MXE makes me feel very strong.

 

[zzz101]

If someone has a huge opioid tolerance sometimes Ketamine(or whatever else is best) can be used for pain-killer effects.

MXE is similar to Ketamine is many ways. but also slightly different with a longer half life.
i prefer MXE for everything except 100mg + doses

 

[AA357]

If someone has a huge opioid tolerance sometimes Ketamine(or whatever else is best) can be used for pain-killer effects.

There is plenty of literature out there about the co-analgesic effects of Ketamine and opioid painkillers, but nothing about the analgesic effects of sub-anaesthetic doses of Ketamine alone.
I do have a low opioid tolerance, but I have tried a lot of them. IME, insufflated MXE blows even IV fentanyl out of the water as far as pain relief goes.
Unlike some anaesthetics (e.g. propofol), NMDA antagonists do provide powerful analgesia at sub-anaesthetic doses.

MXE is similar to Ketamine is many ways. but also slightly different with a longer half life.
i prefer MXE for everything except 100mg + doses

Ketamine mongs me out and makes me feel very vulnerable, whereas MXE jacks me up and makes me feel like I could take on the world. As anaesthetics I would say they are equally effective.
100mg+ is extremely dissociating. I only ever use this amount when I'm in serious pain, or when I want to get extremely fucked up. Take enough MXE and you could end up seriously injuring yourself and not even realizing it until the morning after.

 

[dopamimetic]

The chemist who discovered MXE actually searched for and used it to treat phantom pain...!

I think both opioids and dissociatives are potent pain killers but have varying efficacy against different kinds of pain (e.g. neuropathic pain where traditional painkillers sometimes do not work at all). But I agree to that dissociatives are under-rated in this aspect, of course just speculation but they could be of great value for serious pain like in cancer patients.

They also complement each other - dissociatives potentiate opioids and help in keeping tolerance low (dextromethorphan and ketamine are used by health professionals for this, but it is not very widely known). Memantine (the alzheimers drug) has good potential too that is not yet used.

Although - are you serious with 100mg+ of methoxetamine? If such a dose is not fully anesthetic / hypnotic to you, you either have a huge tolerance or seriously cut material.

 

[AA357]

The chemist who discovered MXE actually searched for and used it to treat phantom pain...!

I did read something about that.
I believe it was also designed to be a more bladder-friendly alternative to ketamine.

I think both opioids and dissociatives are potent pain killers but have varying efficacy against different kinds of pain (e.g. neuropathic pain where traditional painkillers sometimes do not work at all). But I agree to that dissociatives are under-rated in this aspect, of course just speculation but they could be of great value for serious pain like in cancer patients.

Personally, I've never experienced a pain that I wasn't able to completely eliminate using MXE. I can't say the same for opioids.
Anaesthetic drugs kill all sensation... if you take enough, it is literally impossible to feel pain.

They also complement each other - dissociatives potentiate opioids and help in keeping tolerance low (dextromethorphan and ketamine are used by health professionals for this, but it is not very widely known). Memantine (the alzheimers drug) has good potential too that is not yet used.

Yes, there's a lot of literature out there about the effects of NMDA angatonist (normally ketamine) + opioid combos in clinical settings.
Truth is, if you're in a lot of pain and you snort a fat line of MXE, opioids will be the last thing on your mind.

Although - are you serious with 100mg+ of methoxetamine? If such a dose is not fully anesthetic / hypnotic to you, you either have a huge tolerance or seriously cut material.

If you read my previous posts you'd notice I mention how 100mg+ is a total mindfuck. As I said before, I only ever take 100mg+ if I'm in SERIOUS pain that my codeine tabs don't touch (like when I got knocked off my bike by a car doing 40mph, when I badly broke a finger doing BJJ, and for excruciating dental pain). High doses are extremely dissociating - I feel like a floating head (can't feel my fucking physical self let alone pain).

I do have a slight tolerance but I find 30-75mg excellent for moderate to fairly severe pain (I notice analgesic effects with as little as 25mg). At <75mg, it's spacey but not so disorienting that I can't function normally (that said, I would STRONGLY advise against driving on dissociative anaesthetics... they really impair your judgment big time, moreso than any other type of drug IME).