Here is some of my experience with MXE combos, all research on top of marijuana vapor:
Researched it with MDMA+3.5 cubensis, dosed it during the second half but was still feeling residual MXE effects from the night before, noticed this because the trip was completely different from the onset, was a hyper intense experience, quite amazing, not terribly visual but incredible thoughts/feelings, was quite delusional throughout though, I mean it was an insane trip involving religion and all kinds of craziness, very good though.
AMT + MXE 4/5hrs in was incredible, difficult to describe but basically incredible euphoria, in a party setting, everyone talking about futuristic stuff, kinda made everything very sci-fi. The same night DMT was administered at the end, repeated vapes between several subjects, amazing feeling, goods trips all-round, BUT there was an interesting side effect of this, shortly after the DMT, people became concerned about having too much fun, discussion took a more reflective, contemplative, sombre tone and the wkd was over shortly after.. this kind of effect I've experienced before, and I consider it more of a positive reflection from the trip, it's like, OK you've had enough fun, time to look after yourself and call it a night. I would consider the DMT a trip killer at this level, almost.
200mg MDAI + MXE - I know it's not a tryptamine but I'll post anyway, not bad, kinda felt to me as if it was going in different directions, but still felt great, had a very open night, strong em-pathogenic qualities.
Kratom + MXE again half way through, only a little bit though - alright, 2 effects overlap but this was not actually enjoyable for me, I felt quite a lot of CNS depression and generally the effects were basic, maybe more MXE would've been better, but it didn't actually feel that safe TBH.
30mgCodeine/10mgValium/KavaKava/MXE - small amounts of everything, this was kinda super lovely actually, very laid back, super relaxed as you'd imagine but again, I could've been pushing things very stupidly with this, just posting my experience.